Title:
BIOMARKERS FOR STROKE
Document Type and Number:
WIPO Patent Application WO/2012/021407
Kind Code:
A3
Abstract:
Biomarkers for stroke and methods for their detection are disclosed. In one aspect, the present application discloses biomarkers for the diagnosis of stroke in a subject. In another aspect, the application discloses a method for the diagnosis of stroke in a subject. The method comprises detection of stroke biomarkers in cerebrospinal fluid, blood, serum or PMBCs of a subject. Also disclosed is a kit for the detection of biomarkers for the diagnosis of stroke in a subject.
Inventors:
FORD BYRON D (US)
Application Number:
PCT/US2011/046777
Publication Date:
August 16, 2012
Filing Date:
August 05, 2011
Export Citation:
Assignee:
MOREHOUSE SCHOOL OF MEDICINE (US)
FORD BYRON D (US)
FORD BYRON D (US)
International Classes:
G01N33/68; C12Q1/68; G01N33/15
Other References:
LEGOS, J. J. ET AL.: "Quantitative changes in interleukin proteins following focal stroke in the rat.", NEUROSCIENCE LETTERS, vol. 282, 2000, pages 189 - 192
BOUTIN, H. ET AL.: "Role of IL-lalpha and IL-beta in ischemic brain damage.", J. NEUROSCI., vol. 21, no. 15, 2001, pages 5528 - 5534
HILL, J. K. ET AL.: "Temporal modulation of cytokine expression following focal cerebral ischemia in mice.", BRAIN RESEARCH, vol. 820, 1999, pages 45 - 54, XP002228974, DOI: doi:10.1016/S0006-8993(98)01140-8
ADIBHATLA, R. M. ET AL.: "Secretory phospholipase A2 IIA is up-regulated by TNF-alpha and IL-lalpha/beta after transient focal cerebral ischemia in rat.", BRAIN RESEARCH, vol. 1134, 2007, pages 199 - 205
BOUTIN, H. ET AL.: "Role of IL-lalpha and IL-beta in ischemic brain damage.", J. NEUROSCI., vol. 21, no. 15, 2001, pages 5528 - 5534
HILL, J. K. ET AL.: "Temporal modulation of cytokine expression following focal cerebral ischemia in mice.", BRAIN RESEARCH, vol. 820, 1999, pages 45 - 54, XP002228974, DOI: doi:10.1016/S0006-8993(98)01140-8
ADIBHATLA, R. M. ET AL.: "Secretory phospholipase A2 IIA is up-regulated by TNF-alpha and IL-lalpha/beta after transient focal cerebral ischemia in rat.", BRAIN RESEARCH, vol. 1134, 2007, pages 199 - 205
Attorney, Agent or Firm:
WANG, Ping, M.D. (LLP1350 I Street, N.W. Suite 110, Washington DC, US)
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