Title:
BIOMARKERS FOR TANGLE-PREDOMINANT DEMENTIA
Document Type and Number:
WIPO Patent Application WO/2013/192522
Kind Code:
A3
Abstract:
This invention relates to the field of screening for, identifying, and diagnosing tangle- predominant dementia (TPD). Specifically, this invention provides various biomarkers for this disease, and methods of using these biomarkers to correctly subclassify patients with Alzheimer's-type dementia by differentiating TPD patients from those with classical Alzheimer's disease (AD), as well as prodromal AD, and mild cognitive impairment due to AD.
Inventors:
CRARY JOHN (US)
Application Number:
PCT/US2013/047047
Publication Date:
March 05, 2015
Filing Date:
June 21, 2013
Export Citation:
Assignee:
UNIV COLUMBIA (US)
International Classes:
C12Q1/68; G01N33/53
Foreign References:
| US20050124016A1 | 2005-06-09 | |||
| US20110177509A1 | 2011-07-21 | |||
| US20040181048A1 | 2004-09-16 | |||
| US20050228172A9 | 2005-10-13 | |||
| US20060194211A1 | 2006-08-31 |
Other References:
JELLINGER ET AL.: "Neurofibrillary tangle-predominant dementia: comparison with classical Alzheimer disease.", ACTA NEUROPATHOL, vol. 113, no. 2, February 2007 (2007-02-01), pages 107 - 17, XP019473748
MURRAY ET AL.: "Neuropathologically defined subtypes of Alzheimer's disease with distinct clinical characteristics: a retrospective study.", LANCET NEUROL, vol. 10, no. 9, September 2011 (2011-09-01), pages 785 - 96, XP055183487
THINAKARAN ET AL.: "Amyloid precursor protein trafficking, processing, and function.", J BIOL CHEM, vol. 283, no. 44, 31 October 2008 (2008-10-31), pages 29615 - 9, XP055183489
SANTA-MARIA ET AL.: "The MAPT H1 haplotype is associated with tangle-predominant dementia.", ACTA NEUROOATHOL., vol. 124, no. 5, November 2012 (2012-11-01), pages 693 - 704, XP035125362
JANOCKO ET AL.: "Neuropathologically defined subtypes of Alzheimer's disease differ significantly from neurofibrillary tangle-predominant dementia.", ACTA NEUROPATHOL., vol. 124, no. 5, November 2012 (2012-11-01), pages 681 - 92, XP035125365
NEVE ET AL.: "Dysfunction of amyloid precursor protein signaling in neurons leads to DNA synthesis and apoptosis.", BIOCHIM BIOPHYS ACTA, vol. 1772, no. 4, 2007, pages 430 - 7, XP055183494
DATABASE GENBANK [online] 3 May 2005 (2005-05-03), MATTHEWS,L.: "HUMAN DNA SEQUENCE FROM CLONE RP11-669E14, COMPLETE SEQUENCE", XP003034293, Database accession no. CR936218.6
DATABASE GENBANK [online] 30 April 2011 (2011-04-30), BOATRIGHT, E.: "HOMO SAPIENS BAC CLONE CH17-170H8 FROM CHROMOSOME UNKNOWN, COMPLETE SEQUENCE", XP003034294, Database accession no. AC243658.3
DATABASE GENBANK [online] 5 November 2011 (2011-11-05), "HOMO SAPIENS MICROTUBULE-ASSOCIATED PROTEIN TAU (MAPT), REFSEQGENE ON CHROMOSOME17", XP003034295, Database accession no. NG_007398.1
MURRAY ET AL.: "Neuropathologically defined subtypes of Alzheimer's disease with distinct clinical characteristics: a retrospective study.", LANCET NEUROL, vol. 10, no. 9, September 2011 (2011-09-01), pages 785 - 96, XP055183487
THINAKARAN ET AL.: "Amyloid precursor protein trafficking, processing, and function.", J BIOL CHEM, vol. 283, no. 44, 31 October 2008 (2008-10-31), pages 29615 - 9, XP055183489
SANTA-MARIA ET AL.: "The MAPT H1 haplotype is associated with tangle-predominant dementia.", ACTA NEUROOATHOL., vol. 124, no. 5, November 2012 (2012-11-01), pages 693 - 704, XP035125362
JANOCKO ET AL.: "Neuropathologically defined subtypes of Alzheimer's disease differ significantly from neurofibrillary tangle-predominant dementia.", ACTA NEUROPATHOL., vol. 124, no. 5, November 2012 (2012-11-01), pages 681 - 92, XP035125365
NEVE ET AL.: "Dysfunction of amyloid precursor protein signaling in neurons leads to DNA synthesis and apoptosis.", BIOCHIM BIOPHYS ACTA, vol. 1772, no. 4, 2007, pages 430 - 7, XP055183494
DATABASE GENBANK [online] 3 May 2005 (2005-05-03), MATTHEWS,L.: "HUMAN DNA SEQUENCE FROM CLONE RP11-669E14, COMPLETE SEQUENCE", XP003034293, Database accession no. CR936218.6
DATABASE GENBANK [online] 30 April 2011 (2011-04-30), BOATRIGHT, E.: "HOMO SAPIENS BAC CLONE CH17-170H8 FROM CHROMOSOME UNKNOWN, COMPLETE SEQUENCE", XP003034294, Database accession no. AC243658.3
DATABASE GENBANK [online] 5 November 2011 (2011-11-05), "HOMO SAPIENS MICROTUBULE-ASSOCIATED PROTEIN TAU (MAPT), REFSEQGENE ON CHROMOSOME17", XP003034295, Database accession no. NG_007398.1
Attorney, Agent or Firm:
CARNEY, Bonnie Kramer et al. (One Barker AvenueFifth Floo, White Plains NY, US)
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