Title:
BIOMARKERS FOR A THERAPY COMPRISING AN ANGIOGENESIS INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2023/002725
Kind Code:
A1
Abstract:
Biomarkers are provided that predict whether a human subject having a tumor is in need of a therapy comprising an angiogenesis inhibitor (e.g. lenvatinib or a pharmaceutically acceptable salt thereof, such as lenvatinib mesylate). The biomarkers, compositions, and methods described herein are useful in selecting appropriate treatment modalities for and treating a subject having a tumor.
Inventors:
KURONISHI MEGUMI (JP)
KATO YU (JP)
KATO YU (JP)
Application Number:
PCT/JP2022/017262
Publication Date:
January 26, 2023
Filing Date:
April 07, 2022
Export Citation:
Assignee:
EISAI R&D MAN CO LTD (JP)
International Classes:
A61K45/00; A61P35/00; C12Q1/68; G01N33/48; G01N33/50; G01N33/68
Domestic Patent References:
| WO1998025946A1 | 1998-06-18 |
Foreign References:
| US20130230511A1 | 2013-09-05 |
Other References:
IRANI SOUSSAN, DEHGHAN ARASH: "Expression of vascular endothelial-cadherin in mucoepidermoid carcinoma: Role in cancer development", JOURNAL OF INTERNATIONAL SOCIETY OF PREVENTIVE AND COMMUNITY DENTISTRY, INTERNATIONAL SOCIETY OF PREVENTIVE AND COMMUNITY DENTISTRY [, IN, vol. 7, no. 6, 1 January 2017 (2017-01-01), IN , pages 301, XP093026264, ISSN: 2231-0762, DOI: 10.4103/jispcd.JISPCD_323_17
LEGAN MATEJA: "New marker of angiogenesis CD105 (endoglin): diagnostic, prognostic and therapeutic role", RADIOL ONCOL., SLOVENIAN MEDICAL SOCIETY - SECTION OF RADIOLOGY, vol. 39, no. 4, 1 January 2005 (2005-01-01), pages 253 - 259, XP093026267
ZHANG XIANYUN, JI JINDONG, ZHANG GUANGBO, FANG CHUNTAO, JIANG FUJIN, MA SONG, HOU JIANQUAN: "Expression and significance of B7-H3 and Tie-2 in the tumor vasculature of clear cell renal carcinoma", ONCOTARGETS AND THERAPY, vol. Volume 10, 13 November 2017 (2017-11-13), pages 5417 - 5424, XP093026268, DOI: 10.2147/OTT.S147041
GAGLIARDI FILIPPO; NARAYANAN ASHWIN; GALLOTTI ALBERTO LUIGI; PIERI VALENTINA; MAZZOLENI STEFANIA; COMINELLI MANUELA; REZZOLA SARA;: "Enhanced SPARCL1 expression in cancer stem cells improves preclinical modeling of glioblastoma by promoting both tumor infiltration and angiogenesis", NEUROBIOLOGY OF DISEASE, ELSEVIER, AMSTERDAM, NL, vol. 134, 10 December 2019 (2019-12-10), AMSTERDAM, NL , XP085995011, ISSN: 0969-9961, DOI: 10.1016/j.nbd.2019.104705
YUJI YAMAMOTO;JUNJI MATSUI;TOMOHIRO MATSUSHIMA;HIROSHI OBAISHI;KAZUKI MIYAZAKI;KATSUJI NAKAMURA;OSAMU TOHYAMA;TARO SEMBA;ATSUMI YA: "Lenvatinib, an angiogenesis inhibitor targeting VEGFR/FGFR, shows broad antitumor activity in human tumor xenograft models associated with microvessel density and pericyte coverage", VASCULAR CELL, BIOMED CENTRAL LTD, LONDON, UK, vol. 6, no. 1, 6 September 2014 (2014-09-06), London, UK , pages 18, XP021196244, ISSN: 2045-824X, DOI: 10.1186/2045-824X-6-18
LEGAN MATEJA: "New marker of angiogenesis CD105 (endoglin): diagnostic, prognostic and therapeutic role", RADIOL ONCOL., SLOVENIAN MEDICAL SOCIETY - SECTION OF RADIOLOGY, vol. 39, no. 4, 1 January 2005 (2005-01-01), pages 253 - 259, XP093026267
ZHANG XIANYUN, JI JINDONG, ZHANG GUANGBO, FANG CHUNTAO, JIANG FUJIN, MA SONG, HOU JIANQUAN: "Expression and significance of B7-H3 and Tie-2 in the tumor vasculature of clear cell renal carcinoma", ONCOTARGETS AND THERAPY, vol. Volume 10, 13 November 2017 (2017-11-13), pages 5417 - 5424, XP093026268, DOI: 10.2147/OTT.S147041
GAGLIARDI FILIPPO; NARAYANAN ASHWIN; GALLOTTI ALBERTO LUIGI; PIERI VALENTINA; MAZZOLENI STEFANIA; COMINELLI MANUELA; REZZOLA SARA;: "Enhanced SPARCL1 expression in cancer stem cells improves preclinical modeling of glioblastoma by promoting both tumor infiltration and angiogenesis", NEUROBIOLOGY OF DISEASE, ELSEVIER, AMSTERDAM, NL, vol. 134, 10 December 2019 (2019-12-10), AMSTERDAM, NL , XP085995011, ISSN: 0969-9961, DOI: 10.1016/j.nbd.2019.104705
YUJI YAMAMOTO;JUNJI MATSUI;TOMOHIRO MATSUSHIMA;HIROSHI OBAISHI;KAZUKI MIYAZAKI;KATSUJI NAKAMURA;OSAMU TOHYAMA;TARO SEMBA;ATSUMI YA: "Lenvatinib, an angiogenesis inhibitor targeting VEGFR/FGFR, shows broad antitumor activity in human tumor xenograft models associated with microvessel density and pericyte coverage", VASCULAR CELL, BIOMED CENTRAL LTD, LONDON, UK, vol. 6, no. 1, 6 September 2014 (2014-09-06), London, UK , pages 18, XP021196244, ISSN: 2045-824X, DOI: 10.1186/2045-824X-6-18
Attorney, Agent or Firm:
HASEGAWA Yoshiki et al. (JP)
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