Title:
BIOMATERIAL SUBSTRATES
Document Type and Number:
WIPO Patent Application WO2002101028
Kind Code:
A3
Abstract:
The present invention relates to novel substrates, to methods of making them and to uses therefor. The substrates of the invention comprise a base portion and a surface layer covering at least part of the base portion, with a binding layer provided therebetween. The surface layer provides, on at least a part of the substrate, topographical features having at least one nano scale dimension. These topographical features are adapted to facilitate, influence, control or inhibit cell or tissue growth thereon and/or therebetween and the substrate may be used for the study, manipulation or modification of at least one cellular or tissue behaviour or response.
Inventors:
COUSINS BRIAN G (GB)
GARVEY MICHAEL JOSEPH (GB)
FINK JOHN (GB)
WILLIAMS RACHEL LUCINDA (GB)
DOHERTY PATRICK JOSEPH (GB)
GARVEY MICHAEL JOSEPH (GB)
FINK JOHN (GB)
WILLIAMS RACHEL LUCINDA (GB)
DOHERTY PATRICK JOSEPH (GB)
Application Number:
PCT/GB2002/002652
Publication Date:
May 22, 2003
Filing Date:
June 11, 2002
Export Citation:
Assignee:
UNIV LIVERPOOL (GB)
COUSINS BRIAN G (GB)
GARVEY MICHAEL JOSEPH (GB)
FINK JOHN (GB)
WILLIAMS RACHEL LUCINDA (GB)
DOHERTY PATRICK JOSEPH (GB)
COUSINS BRIAN G (GB)
GARVEY MICHAEL JOSEPH (GB)
FINK JOHN (GB)
WILLIAMS RACHEL LUCINDA (GB)
DOHERTY PATRICK JOSEPH (GB)
International Classes:
A61L15/24; A61L15/42; A61L27/34; A61L27/50; C12N5/00; C12N5/02; (IPC1-7): C12N5/00; B05D5/00
Domestic Patent References:
| WO2000066036A2 | 2000-11-09 |
Foreign References:
| EP1040874A2 | 2000-10-04 | |||
| EP1095760A1 | 2001-05-02 |
Other References:
FLEMMING R G ET AL: "EFFECTS OF SYNTHETIC MICRO-AND NANO-STRUCTURED SURFACES ON CELL BEHAVIOR", BIOMATERIALS, ELSEVIER SCIENCE PUBLISHERS BV., BARKING, GB, vol. 20, March 1999 (1999-03-01), pages 573 - 588, XP002926697, ISSN: 0142-9612
DEN BRABER E T ET AL: "Quantitative analysis of cell proliferation and orientation on substrata with uniform parallel surface micro-grooves", BIOMATERIALS, ELSEVIER SCIENCE PUBLISHERS BV., BARKING, GB, vol. 17, no. 11, 1996, pages 1093 - 1099, XP004032669, ISSN: 0142-9612
OAKLEY CAROL ET AL: "Sensitivity of fibroblasts and their cytoskeletons to substratum topographies: Topographic guidance and topographic compensation by micromachined grooves of different dimensions.", EXPERIMENTAL CELL RESEARCH, vol. 234, no. 2, 1997, pages 413 - 424, XP002229298, ISSN: 0014-4827
DEN BRABER E T ET AL: "Quantitative analysis of cell proliferation and orientation on substrata with uniform parallel surface micro-grooves", BIOMATERIALS, ELSEVIER SCIENCE PUBLISHERS BV., BARKING, GB, vol. 17, no. 11, 1996, pages 1093 - 1099, XP004032669, ISSN: 0142-9612
OAKLEY CAROL ET AL: "Sensitivity of fibroblasts and their cytoskeletons to substratum topographies: Topographic guidance and topographic compensation by micromachined grooves of different dimensions.", EXPERIMENTAL CELL RESEARCH, vol. 234, no. 2, 1997, pages 413 - 424, XP002229298, ISSN: 0014-4827
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