Title:
BIOMATERIALS FOR COMBINED RADIOTHERAPY AND IMMUNOTHERAPY OF CANCER
Document Type and Number:
WIPO Patent Application WO/2017/027874
Kind Code:
A8
Abstract:
Compositions and methods for the radiological and immunotherapeutic treatment of cancer are provided. Metallic nanoparticles conjugated with an immunoadjuvant are dispersed within a biodegradable polymer matrix that can be implanted in a patient and released gradually. The implant may be configured as, or be a component of, brachytherapy spacers and applicators, or radiotherapy fiducial markers. The composition may be combined with marginless radiotherapy, allowing for lower doses of radiation and enhancing the immune response against cancer, including at non-irradiated sites.
More Like This:
Inventors:
NGWA WILFRED (US)
KUMAR RAJIV (US)
MAKRIGIORGOS GERASSIMOS (US)
SRIDHAR SRINIVAS (US)
DOUGAN STEPHANIE (US)
KUMAR RAJIV (US)
MAKRIGIORGOS GERASSIMOS (US)
SRIDHAR SRINIVAS (US)
DOUGAN STEPHANIE (US)
Application Number:
PCT/US2016/046992
Publication Date:
March 22, 2018
Filing Date:
August 15, 2016
Export Citation:
Assignee:
UNIV NORTHEASTERN (US)
DANA FARBER CANCER INST INC (US)
BRIGHAM & WOMENS HOSPITAL INC (US)
DANA FARBER CANCER INST INC (US)
BRIGHAM & WOMENS HOSPITAL INC (US)
International Classes:
A61K41/00; A61K39/00
Attorney, Agent or Firm:
HYMEL, Lin, J. (US)
Download PDF:
Previous Patent: ADJUSTABLE SPINAL IMPLANT
Next Patent: STRAPPING APPARATUS FOR PACKAGES AND STRAPPING METHOD
Next Patent: STRAPPING APPARATUS FOR PACKAGES AND STRAPPING METHOD