Title:
BIOMOLECULAR SENSING WITH METAL-NANOSTRUCTURES
Document Type and Number:
WIPO Patent Application WO/2010/115147
Kind Code:
A3
Abstract:
Systems and methods for providing biomolecule interaction sites are disclosed. In certain embodiments, coupling of two or more different metal-nanoparticles can provide a significant increase in flexibility in controlling parameters associated with excitation of fluorophores attached to the biomolecules. Types and number of metal-nanoparticles and spatial arrangement of such nanoparticles are some of the parameters that can be adjusted to control fluorescence parameters such as excitation wavelengths and intensity of fluorescence. In certain embodiments, enhanced fluorescence effect can be confined to a sufficiently small region so as to allow sensing of one biomolecule at a time. Combined with enhanced fluorescence intensity, such small enhancement region can be used to perform processes such as real-time DNA sequencing.
Inventors:
SUN HONGYE (US)
OLDHAM MARK (US)
OLDHAM MARK (US)
Application Number:
PCT/US2010/029841
Publication Date:
January 13, 2011
Filing Date:
April 02, 2010
Export Citation:
Assignee:
LIFE TECHNOLOGIES CORP (US)
SUN HONGYE (US)
OLDHAM MARK (US)
SUN HONGYE (US)
OLDHAM MARK (US)
International Classes:
G01N33/48; C12Q1/68
Domestic Patent References:
| WO2008029374A2 | 2008-03-13 |
Foreign References:
| US20060240573A1 | 2006-10-26 | |||
| US20070026531A1 | 2007-02-01 |
Attorney, Agent or Firm:
KUAN, Roger (c/o Intellevate CorporationP.O. Box 5205, Minneapolis Minnesota, US)
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