Title:
BIOMOLECULE DETECTION METHOD, BIOMOLECULE DETECTION DEVICE AND ANALYSIS DEVICE
Document Type and Number:
WIPO Patent Application WO/2014/024598
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a method for detecting biomolecules over a broad dynamic range at a high sensitivity and a high throughput without preliminarily controlling the concentration of a sample, and a device therefor. According to the present invention, charge holding bodies are specifically attached to biomolecules to be detected. Then, a current change caused by the passage of the composite bodies thus formed through a micropore is measured so that the biomolecules to be detected are detected one by one. By using an array structure in a detection part, a biomolecule sample can be detected at a high throughput.
Inventors:
SAITO TOSHIRO (JP)
IMAI KENTA (JP)
IMAI KYOKO (JP)
IMAI KAZUMICHI (JP)
YANAGI ITARU (JP)
YANAGAWA YOSHIMITSU (JP)
ANDO MASAHIKO (JP)
ITABASHI NAOSHI (JP)
IMAI KENTA (JP)
IMAI KYOKO (JP)
IMAI KAZUMICHI (JP)
YANAGI ITARU (JP)
YANAGAWA YOSHIMITSU (JP)
ANDO MASAHIKO (JP)
ITABASHI NAOSHI (JP)
Application Number:
PCT/JP2013/067755
Publication Date:
February 13, 2014
Filing Date:
June 28, 2013
Export Citation:
Assignee:
HITACHI HIGH TECH CORP (JP)
International Classes:
G01N27/02; G01N27/00; G01N33/543; G01N37/00
Foreign References:
| US20110133255A1 | 2011-06-09 | |||
| JP2003533676A | 2003-11-11 | |||
| JP2005304376A | 2005-11-04 | |||
| JP2010230614A | 2010-10-14 | |||
| US20100327847A1 | 2010-12-30 | |||
| JP2009543058A | 2009-12-03 | |||
| JP2010133948A | 2010-06-17 | |||
| JP2012026986A | 2012-02-09 | |||
| JP2011211905A | 2011-10-27 | |||
| JP2011501806A | 2011-01-13 | |||
| US20110237000A1 | 2011-09-29 | |||
| JP4748542B2 | 2011-08-17 |
Other References:
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BARLETTA, J.M.; EDELMAN, D.C.; CONSTANTINE, N.T.: "Lowering the detection limits of HIV-1 viral load using real-time immuno-PCR for HIV-1 p24 antigen", AM. J. CLIN. PATHOL., vol. 122, 2004, pages 20 - 27
GILJOHANN, D.A.; MIRKIN, C.A.: "Drivers of biodiagnostic development", NATURE, vol. 462, 2009, pages 461 - 464
DAVID M RISSIN ET AL., NATURE BIOTECHNOLOGY, vol. 28, 2010, pages 1641
FOLOGEA D. ET AL., APPL PHYS LETT., vol. 91, 2007, pages 053901 - 3
ROMERO-CANO, M. S. ET AL., JOURNAL OF COLLOID AND INTERFACE SCIENCE, vol. 198, 1998, pages 266 - 272
GALASKO, D.: "Biomarkers for Alzheimer's disease - clinical needs and application", J. ALZHEIMERS DIS., vol. 8, 2005, pages 339 - 346
BARLETTA, J.M.; EDELMAN, D.C.; CONSTANTINE, N.T.: "Lowering the detection limits of HIV-1 viral load using real-time immuno-PCR for HIV-1 p24 antigen", AM. J. CLIN. PATHOL., vol. 122, 2004, pages 20 - 27
GILJOHANN, D.A.; MIRKIN, C.A.: "Drivers of biodiagnostic development", NATURE, vol. 462, 2009, pages 461 - 464
DAVID M RISSIN ET AL., NATURE BIOTECHNOLOGY, vol. 28, 2010, pages 1641
FOLOGEA D. ET AL., APPL PHYS LETT., vol. 91, 2007, pages 053901 - 3
ROMERO-CANO, M. S. ET AL., JOURNAL OF COLLOID AND INTERFACE SCIENCE, vol. 198, 1998, pages 266 - 272
Attorney, Agent or Firm:
INOUE Manabu et al. (JP)
Manabu Inoue (JP)
Manabu Inoue (JP)
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