Title:
BIOMOLECULE IMAGING METHOD USING APTAMER
Document Type and Number:
WIPO Patent Application WO/2018/199607
Kind Code:
A1
Abstract:
The present invention relates to a composition for imaging a tumorous disease region, comprising a fluorescence- or radioactive isotope-labeled ERBB2 aptamer, wherein an ERBB2 aptamer labeled with a radioactive isotope or a phosphorescent dye is used to image a tumorous disease region in vivo.
Inventors:
LEE JUNG HWAN (KR)
KIM JONG IN (KR)
IM JONG HUN (KR)
LEE JONG OOK (KR)
KIM JIN WOO (KR)
KIM JONG IN (KR)
IM JONG HUN (KR)
LEE JONG OOK (KR)
KIM JIN WOO (KR)
Application Number:
PCT/KR2018/004770
Publication Date:
November 01, 2018
Filing Date:
April 25, 2018
Export Citation:
Assignee:
INTEROLIGO CORP (KR)
International Classes:
A61K51/04; G01N33/53; G01N33/574
Foreign References:
| KR20130003071A | 2013-01-09 | |||
| US20090004667A1 | 2009-01-01 | |||
| US20150005368A1 | 2015-01-01 | |||
| KR20170053456A | 2017-05-16 |
Other References:
KIM, MEE YOUNG ET AL.: "In Vitro Selection of RNA Aptamer and Specific Targeting of ErbB2 in Breast Cancer Cells", NUCLEIC ACID THERAPEUTICS, vol. 21, no. 3, June 2011 (2011-06-01), pages 173 - 178, XP055404619
MOOSAVIAN, SEYEDEH ALIA ET AL.: "Development of RNA Aptamers as Molecular Probes for HER2+ Breast Cancer Study Using Cell -SELEX", IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 18, no. 6, June 2015 (2015-06-01), pages 576 - 586, XP055528633
KANG, HYE SUK ET AL.: "Isolation of RNA Aptamers Targeting HER-2-overexpressing Breast Cancer Cells Using Cell -SELEX", BULLETIN OF THE KOREAN CHEMICAL SOCIETY, vol. 30, no. 8, 2009, pages 1827 - 1831, XP055652149, ISSN: 0253-2964
See also references of EP 3636287A4
TUERK CGOLD L: "Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase", SCIENCE, vol. 249, 1990, pages 505 - 10, XP000647748, DOI: 10.1126/science.2200121
ELLINGTON ADSZOSTAK JW: "In vitro selection of RNA molecules that bind specific ligands", NATURE, vol. 346, 1990, pages 818 - 22, XP002547962, DOI: 10.1038/346818a0
STOLTENBURG RREINEMANN CSTREHLITZ B: "SELEX - a (r) evolutionary method to generate high-affinity nucleic acid ligands", BIOMOLECULAR ENGINEERING, vol. 24, 2007, pages 381 - 403, XP022251573, DOI: 10.1016/j.bioeng.2007.06.001
SPIRIDONOVA VAKOPYLOV AM: "DNA aptamers as radically new recognition elements for biosensors", BIOCHEMISTRY BIOKHIMIIA, vol. 67, 2002, pages 706 - 9, XP008027815, DOI: 10.1023/A:1016110724564
JAYASENA SD: "Aptamers: an emerging class of molecules that rival antibodies in diagnostics", CLINICAL CHEMISTRY, vol. 45, 1999, pages 1628 - 50
BOCK LCGRIFFIN LCLATHAM JAVERMAAS EHTOOLE JJ: "Selection of single-stranded DNA molecules that bind and inhibit human thrombin", NATURE, vol. 355, no. 6360, 1992, pages 564 - 6, XP000453533, DOI: 10.1038/355564a0
BATES PJLABER DAMILLER DMTHOMAS SDTRENT JO: "Discovery and development of the G-rich oligonucleotide AS1411 as a novel treatment for cancer", EXPERIMENTAL AND MOLECULAR PATHOLOGY, vol. 86, 2009, pages 151 - 64, XP026096499, DOI: 10.1016/j.yexmp.2009.01.004
LUPOLD SEHICKE BJLIN YCOFFEY DS: "Identification and characterization of nuclease-stabilized RNA molecules that bind human prostate cancer cells via the prostate-specific membrane antigen", CANCER RESEARCH, vol. 62, 2002, pages 4029 - 33
DANIELS DACHEN HHICKE BJSWIDEREK KMGOLD L: "A tenaascin-C aptamer identified by tumor cell SELEX: systematic evolution of ligands by exponential enrichment", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 100, 2003, pages 15416 - 21, XP002341306, DOI: 10.1073/pnas.2136683100
JAMES W: "Aptamers in the virologists' toolkit", THE JOURNAL OF GENERAL VIROLOGY, vol. 88, 2007, pages 351 - 64
DOGGRELL SA: "Pegaptanib: the first antiangiogenic agent approved for neovascular macular degeneration", EXPERT OPINION ON PHARMACOTHERAPY, vol. 6, 2005, pages 1421 - 3
DAUSSE EDA ROCHA GOMES STOULME JJ: "aptamers: a new class of oligonucleotides in the drug discovery pipeline?", CURRENT OPINION IN PHARMACOLOGY, vol. 9, 2009, pages 602 - 7, XP026665554, DOI: 10.1016/j.coph.2009.07.006
MITRI ZCONSTANTINE TO'REGAN R: "The HER2 Receptor in Breast Cancer: Pathophysiology, Clinical Use, and New Advances in Therapy", CHEMOTHERAPY RESEARCH AND PRACTICE, vol. 2012, 2012, pages 743193
BURSTEIN HJ: "The distinctive nature of HER2-positive breast cancers", THE NEW ENGLAND JOURNAL OF MEDICINE, vol. 353, 2005, pages 1652 - 4
TAN MYU D: "Molecular mechanisms of erbB2-mediated breast cancer chemoresistance", ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY, vol. 608, 2007, pages 119 - 29
BASELGA JSWAIN SM: "Novel anticancer targets: revisiting ERBB2 and discovering ERBB3", NATURE REVIEWS CANCER, vol. 9, 2009, pages 463 - 75, XP009139034, DOI: 10.1038/nrc2656
DASTJERDI KTABAR GHDEHGHANI HHAGHPARAST A: "Generation of an enriched pool of DNA aptamers for an HER2-overexpressing cell line selected by Cell SELEX", BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY, vol. 58, 2011, pages 226 - 30, XP002715519, DOI: 10.1002/bab.36
LIU ZDUAN JHSONG YMMA JWANG FDLU X ET AL.: "Novel HER2 aptamer selectively delivers cytotoxic drug to HER2-positive breast cancer cells in vitro", JOURNAL OF TRANSLATIONAL MEDICINE, vol. 10, 2012, pages 148, XP021107564, DOI: 10.1186/1479-5876-10-148
MAHLKNECHT GMARON RMANCINI MSCHECHTER BSELA MYARDEN Y: "Aptamer to ErbB-2/HER2 enhances degradation of the target and inhibits tumorigenic growth", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 110, 2013, pages 8170 - 5, XP055097793, DOI: 10.1073/pnas.1302594110
MAHLKNECHT GSELA MYARDEN Y: "Aptamer Targeting the ERBB2 Receptor Tyrosine Kinase for Applications in Tumor Therapy", METHODS IN MOLECULAR BIOLOGY (CLIFTON, NJ, vol. 1317, 2015, pages 3 - 15
MOOSAVIAN SAJAAFARI MRTAGHDISI SMMOSAFFA FBADIEE AABNOUS K: "Development of RNA aptamers as molecular probes for HER2 (+) breast cancer study using cell-SELEX", IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 18, 2015, pages 576 - 86, XP055528633
JAMES MLGAMBHIR SS: "A molecular imaging primer: modalities, imaging agents, and applications", PHYSIOLOGICAL REVIEWS, vol. 92, 2012, pages 897 - 965
HICKE BJSTEPHENS AWGOULD TCHANG YFLYNOTT CKHEIL J ET AL.: "Journal of nuclear medicine: official publication", vol. 56, 2015, SOCIETY OF NUCLEAR MEDICINE, article "PET imaging of tenascin-C with a radiolabeled single-stranded DNA aptamer", pages: 616 - 21
PALA KSERWOTKA AJELEN FJAKIMOWICZ POTLEWSKI J: "Tumor-specific hyperthermia with aptamer-tagged superparamagnetic nanoparticles", INTERNATIONAL JOURNAL OF NANOMEDICINE, vol. 9, 2014, pages 67 - 76
FLAGOTHIER JKAISIN GMERCIER FTHONON DTELLER NWOUTERS J ET AL.: "Synthesis of two new alkyne-bearing linkers used for the preparation of siRNA for labeling by click chemistry with fluorine-18", APPLIED RADIATION AND ISOTOPES: INCLUDING DATA, INSTRUMENTATION AND METHODS FOR USE IN AGRICULTURE, INDUSTRY AND MEDICINE, vol. 70, 2012, pages 1549 - 57, XP028401844, DOI: 10.1016/j.apradiso.2012.04.022
RAMENDA TSTEINBACH JWUEST F: "4- [18F] Fluoro-N-methyl-N- (propyl-2-yn-1-yl) benzenesulfonamide ([18F] F-SA) : a versatile building block for labeling of peptides, proteins and oligonucleotides with fluorine-18 via Cu (I) - mediated click chemistry", AMINO ACIDS, vol. 44, 2013, pages 1167 - 80
ZUKER M: "Mfold web server for nucleic acid folding and hybridization prediction", NUCLEIC ACIDS RESEARCH, vol. 31, no. 13, 2003, pages 3406 - 15, XP002460708, DOI: 10.1093/nar/gkg595
KIBBE WA: "OligoCalc: an online oligonucleotide properties calculator", NUCLEIC ACIDS RESEARCH, vol. 35, 2007, pages 43 - 6
TANG GZENG WYU MKABALKA G: "Facile synthesis of N-succinimidyl 4-[18F] fluorobenzoate ([18F]SFB) for protein labeling", JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS, vol. 51, 2008, pages 68 - 71, XP002503973, DOI: 10.1002/jlcr.1481
TANG GTANG XWANG X: "A facile automated synthesis of N-succinimidyl 4-[18F] fluorobenzoate ([18F]SFB) for 18F-labeled cell-penetrating peptide as PET tracer", JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS, vol. 53, 2010, pages 543 - 7, XP055229135, DOI: 10.1002/jlcr.1758
SCOTT PJHSHAO X: "Fully automated, high yielding production of N-succinimidyl 4- [18F] fluorobenzoate ([18F] SFB), and its use in microwave-enhanced radiochemical coupling reactions", JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS, vol. 53, 2010, pages 586 - 91, XP055030006, DOI: 10.1002/jlcr.1785
KRAUS MHPOPESCU NCAMSBAUGH SCKING CR: "Overexpression of the EGF receptor-related proto-oncogene erbB-2 in human mammary tumor cell lines by different molecular mechanisms", THE EMBO JOURNAL, vol. 6, 1987, pages 605 - 10
VARMIRA KHOSSEINIMEHR SJNOAPARAST ZABEDI SM: "An improved radiolabelled RNA aptamer molecule for HER2 imaging in cancers", JOURNAL OF DRUG TARGETING, vol. 22, 2014, pages 116 - 22
BOUCHARD PRHUTABARAT RMTHOMPSON KM: "Discovery and development of therapeutic aptamers", ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, vol. 50, 2010, pages 237 - 57, XP055058010, DOI: 10.1146/annurev.pharmtox.010909.105547
SUN HZHU XLU PYROSATO RRTAN WZU Y: "Oligonucleotide aptamers: new tools for targeted cancer therapy", MOLECULAR THERAPY NUCLEIC ACIDS, vol. 3, 2014, pages el82
LAO YHPHUA KKLEONG KW: "aptamer nanomedicine for cancer therapeutics: barriers and potential for translation", ACS NANO, vol. 9, 2015, pages 2235 - 54, XP055556155, DOI: 10.1021/nn507494p
SUN HZU Y: "A Highlight of Recent Advances in Aptamer Technology and Its Application", MOLECULES, vol. 20, 2015, pages 11959 - 80
ROSENBERG JEBAMBURY RMVAN ALLEN EMDRABKIN HALARA PN, JR.HARZSTARK AL ET AL.: "A phase II trial of AS1411 (a novel nucleolin-targeted DNA aptamer) in metastatic renal cell carcinoma", INVESTIGATIONAL NEW DRUGS, vol. 32, 2014, pages 178 - 87, XP035906177, DOI: 10.1007/s10637-013-0045-6
DASSIE JPLI HERNANDEZTHOMAS GSLONG MEROCKEY WMCA HOWELL ET AL.: "Targeted inhibition of prostate cancer metastases with an RNA aptamer to prostate-specific membrane antigen", MOLECULAR THERAPY: THE JOURNAL OF THE AMERICAN SOCIETY OF GENE THERAPY, vol. 22, 2014, pages 1910 - 22
XU WSIDDIQUI IANIHAL MPILLA SROSENTHAL KMUKHTAR H ET AL.: "Aptamer-conjugated and doxorubicin-loaded unimolecular micelles for targeted therapy of prostate cancer", BIOMATERIALS, vol. 34, 2013, pages 5244 - 53, XP028593817, DOI: 10.1016/j.biomaterials.2013.03.006
LIM EKKIM BCHOI YRO YCHO EJLEE JH ET AL.: "Aptamer-conjugated magnetic nanoparticles enable efficient targeted detection of integrin alphavbeta3 via magnetic resonance imaging", JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, vol. 102, 2014, pages 49 - 59
HU HDAI ASUN JLI XGAO FWU L ET AL.: "Aptamer-conjugated Mn304 @ Si02 core-shell nanoprobes for targeted magnetic resonance imaging", NANOSCALE, vol. 5, 2013, pages 10447 - 54
MOOSAVIAN, SEYEDEH ALIA ET AL.: "Development of RNA Aptamers as Molecular Probes for HER2+ Breast Cancer Study Using Cell -SELEX", IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 18, no. 6, June 2015 (2015-06-01), pages 576 - 586, XP055528633
KANG, HYE SUK ET AL.: "Isolation of RNA Aptamers Targeting HER-2-overexpressing Breast Cancer Cells Using Cell -SELEX", BULLETIN OF THE KOREAN CHEMICAL SOCIETY, vol. 30, no. 8, 2009, pages 1827 - 1831, XP055652149, ISSN: 0253-2964
See also references of EP 3636287A4
TUERK CGOLD L: "Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase", SCIENCE, vol. 249, 1990, pages 505 - 10, XP000647748, DOI: 10.1126/science.2200121
ELLINGTON ADSZOSTAK JW: "In vitro selection of RNA molecules that bind specific ligands", NATURE, vol. 346, 1990, pages 818 - 22, XP002547962, DOI: 10.1038/346818a0
STOLTENBURG RREINEMANN CSTREHLITZ B: "SELEX - a (r) evolutionary method to generate high-affinity nucleic acid ligands", BIOMOLECULAR ENGINEERING, vol. 24, 2007, pages 381 - 403, XP022251573, DOI: 10.1016/j.bioeng.2007.06.001
SPIRIDONOVA VAKOPYLOV AM: "DNA aptamers as radically new recognition elements for biosensors", BIOCHEMISTRY BIOKHIMIIA, vol. 67, 2002, pages 706 - 9, XP008027815, DOI: 10.1023/A:1016110724564
JAYASENA SD: "Aptamers: an emerging class of molecules that rival antibodies in diagnostics", CLINICAL CHEMISTRY, vol. 45, 1999, pages 1628 - 50
BOCK LCGRIFFIN LCLATHAM JAVERMAAS EHTOOLE JJ: "Selection of single-stranded DNA molecules that bind and inhibit human thrombin", NATURE, vol. 355, no. 6360, 1992, pages 564 - 6, XP000453533, DOI: 10.1038/355564a0
BATES PJLABER DAMILLER DMTHOMAS SDTRENT JO: "Discovery and development of the G-rich oligonucleotide AS1411 as a novel treatment for cancer", EXPERIMENTAL AND MOLECULAR PATHOLOGY, vol. 86, 2009, pages 151 - 64, XP026096499, DOI: 10.1016/j.yexmp.2009.01.004
LUPOLD SEHICKE BJLIN YCOFFEY DS: "Identification and characterization of nuclease-stabilized RNA molecules that bind human prostate cancer cells via the prostate-specific membrane antigen", CANCER RESEARCH, vol. 62, 2002, pages 4029 - 33
DANIELS DACHEN HHICKE BJSWIDEREK KMGOLD L: "A tenaascin-C aptamer identified by tumor cell SELEX: systematic evolution of ligands by exponential enrichment", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 100, 2003, pages 15416 - 21, XP002341306, DOI: 10.1073/pnas.2136683100
JAMES W: "Aptamers in the virologists' toolkit", THE JOURNAL OF GENERAL VIROLOGY, vol. 88, 2007, pages 351 - 64
DOGGRELL SA: "Pegaptanib: the first antiangiogenic agent approved for neovascular macular degeneration", EXPERT OPINION ON PHARMACOTHERAPY, vol. 6, 2005, pages 1421 - 3
DAUSSE EDA ROCHA GOMES STOULME JJ: "aptamers: a new class of oligonucleotides in the drug discovery pipeline?", CURRENT OPINION IN PHARMACOLOGY, vol. 9, 2009, pages 602 - 7, XP026665554, DOI: 10.1016/j.coph.2009.07.006
MITRI ZCONSTANTINE TO'REGAN R: "The HER2 Receptor in Breast Cancer: Pathophysiology, Clinical Use, and New Advances in Therapy", CHEMOTHERAPY RESEARCH AND PRACTICE, vol. 2012, 2012, pages 743193
BURSTEIN HJ: "The distinctive nature of HER2-positive breast cancers", THE NEW ENGLAND JOURNAL OF MEDICINE, vol. 353, 2005, pages 1652 - 4
TAN MYU D: "Molecular mechanisms of erbB2-mediated breast cancer chemoresistance", ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY, vol. 608, 2007, pages 119 - 29
BASELGA JSWAIN SM: "Novel anticancer targets: revisiting ERBB2 and discovering ERBB3", NATURE REVIEWS CANCER, vol. 9, 2009, pages 463 - 75, XP009139034, DOI: 10.1038/nrc2656
DASTJERDI KTABAR GHDEHGHANI HHAGHPARAST A: "Generation of an enriched pool of DNA aptamers for an HER2-overexpressing cell line selected by Cell SELEX", BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY, vol. 58, 2011, pages 226 - 30, XP002715519, DOI: 10.1002/bab.36
LIU ZDUAN JHSONG YMMA JWANG FDLU X ET AL.: "Novel HER2 aptamer selectively delivers cytotoxic drug to HER2-positive breast cancer cells in vitro", JOURNAL OF TRANSLATIONAL MEDICINE, vol. 10, 2012, pages 148, XP021107564, DOI: 10.1186/1479-5876-10-148
MAHLKNECHT GMARON RMANCINI MSCHECHTER BSELA MYARDEN Y: "Aptamer to ErbB-2/HER2 enhances degradation of the target and inhibits tumorigenic growth", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 110, 2013, pages 8170 - 5, XP055097793, DOI: 10.1073/pnas.1302594110
MAHLKNECHT GSELA MYARDEN Y: "Aptamer Targeting the ERBB2 Receptor Tyrosine Kinase for Applications in Tumor Therapy", METHODS IN MOLECULAR BIOLOGY (CLIFTON, NJ, vol. 1317, 2015, pages 3 - 15
MOOSAVIAN SAJAAFARI MRTAGHDISI SMMOSAFFA FBADIEE AABNOUS K: "Development of RNA aptamers as molecular probes for HER2 (+) breast cancer study using cell-SELEX", IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 18, 2015, pages 576 - 86, XP055528633
JAMES MLGAMBHIR SS: "A molecular imaging primer: modalities, imaging agents, and applications", PHYSIOLOGICAL REVIEWS, vol. 92, 2012, pages 897 - 965
HICKE BJSTEPHENS AWGOULD TCHANG YFLYNOTT CKHEIL J ET AL.: "Journal of nuclear medicine: official publication", vol. 56, 2015, SOCIETY OF NUCLEAR MEDICINE, article "PET imaging of tenascin-C with a radiolabeled single-stranded DNA aptamer", pages: 616 - 21
PALA KSERWOTKA AJELEN FJAKIMOWICZ POTLEWSKI J: "Tumor-specific hyperthermia with aptamer-tagged superparamagnetic nanoparticles", INTERNATIONAL JOURNAL OF NANOMEDICINE, vol. 9, 2014, pages 67 - 76
FLAGOTHIER JKAISIN GMERCIER FTHONON DTELLER NWOUTERS J ET AL.: "Synthesis of two new alkyne-bearing linkers used for the preparation of siRNA for labeling by click chemistry with fluorine-18", APPLIED RADIATION AND ISOTOPES: INCLUDING DATA, INSTRUMENTATION AND METHODS FOR USE IN AGRICULTURE, INDUSTRY AND MEDICINE, vol. 70, 2012, pages 1549 - 57, XP028401844, DOI: 10.1016/j.apradiso.2012.04.022
RAMENDA TSTEINBACH JWUEST F: "4- [18F] Fluoro-N-methyl-N- (propyl-2-yn-1-yl) benzenesulfonamide ([18F] F-SA) : a versatile building block for labeling of peptides, proteins and oligonucleotides with fluorine-18 via Cu (I) - mediated click chemistry", AMINO ACIDS, vol. 44, 2013, pages 1167 - 80
ZUKER M: "Mfold web server for nucleic acid folding and hybridization prediction", NUCLEIC ACIDS RESEARCH, vol. 31, no. 13, 2003, pages 3406 - 15, XP002460708, DOI: 10.1093/nar/gkg595
KIBBE WA: "OligoCalc: an online oligonucleotide properties calculator", NUCLEIC ACIDS RESEARCH, vol. 35, 2007, pages 43 - 6
TANG GZENG WYU MKABALKA G: "Facile synthesis of N-succinimidyl 4-[18F] fluorobenzoate ([18F]SFB) for protein labeling", JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS, vol. 51, 2008, pages 68 - 71, XP002503973, DOI: 10.1002/jlcr.1481
TANG GTANG XWANG X: "A facile automated synthesis of N-succinimidyl 4-[18F] fluorobenzoate ([18F]SFB) for 18F-labeled cell-penetrating peptide as PET tracer", JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS, vol. 53, 2010, pages 543 - 7, XP055229135, DOI: 10.1002/jlcr.1758
SCOTT PJHSHAO X: "Fully automated, high yielding production of N-succinimidyl 4- [18F] fluorobenzoate ([18F] SFB), and its use in microwave-enhanced radiochemical coupling reactions", JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS, vol. 53, 2010, pages 586 - 91, XP055030006, DOI: 10.1002/jlcr.1785
KRAUS MHPOPESCU NCAMSBAUGH SCKING CR: "Overexpression of the EGF receptor-related proto-oncogene erbB-2 in human mammary tumor cell lines by different molecular mechanisms", THE EMBO JOURNAL, vol. 6, 1987, pages 605 - 10
VARMIRA KHOSSEINIMEHR SJNOAPARAST ZABEDI SM: "An improved radiolabelled RNA aptamer molecule for HER2 imaging in cancers", JOURNAL OF DRUG TARGETING, vol. 22, 2014, pages 116 - 22
BOUCHARD PRHUTABARAT RMTHOMPSON KM: "Discovery and development of therapeutic aptamers", ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, vol. 50, 2010, pages 237 - 57, XP055058010, DOI: 10.1146/annurev.pharmtox.010909.105547
SUN HZHU XLU PYROSATO RRTAN WZU Y: "Oligonucleotide aptamers: new tools for targeted cancer therapy", MOLECULAR THERAPY NUCLEIC ACIDS, vol. 3, 2014, pages el82
LAO YHPHUA KKLEONG KW: "aptamer nanomedicine for cancer therapeutics: barriers and potential for translation", ACS NANO, vol. 9, 2015, pages 2235 - 54, XP055556155, DOI: 10.1021/nn507494p
SUN HZU Y: "A Highlight of Recent Advances in Aptamer Technology and Its Application", MOLECULES, vol. 20, 2015, pages 11959 - 80
ROSENBERG JEBAMBURY RMVAN ALLEN EMDRABKIN HALARA PN, JR.HARZSTARK AL ET AL.: "A phase II trial of AS1411 (a novel nucleolin-targeted DNA aptamer) in metastatic renal cell carcinoma", INVESTIGATIONAL NEW DRUGS, vol. 32, 2014, pages 178 - 87, XP035906177, DOI: 10.1007/s10637-013-0045-6
DASSIE JPLI HERNANDEZTHOMAS GSLONG MEROCKEY WMCA HOWELL ET AL.: "Targeted inhibition of prostate cancer metastases with an RNA aptamer to prostate-specific membrane antigen", MOLECULAR THERAPY: THE JOURNAL OF THE AMERICAN SOCIETY OF GENE THERAPY, vol. 22, 2014, pages 1910 - 22
XU WSIDDIQUI IANIHAL MPILLA SROSENTHAL KMUKHTAR H ET AL.: "Aptamer-conjugated and doxorubicin-loaded unimolecular micelles for targeted therapy of prostate cancer", BIOMATERIALS, vol. 34, 2013, pages 5244 - 53, XP028593817, DOI: 10.1016/j.biomaterials.2013.03.006
LIM EKKIM BCHOI YRO YCHO EJLEE JH ET AL.: "Aptamer-conjugated magnetic nanoparticles enable efficient targeted detection of integrin alphavbeta3 via magnetic resonance imaging", JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, vol. 102, 2014, pages 49 - 59
HU HDAI ASUN JLI XGAO FWU L ET AL.: "Aptamer-conjugated Mn304 @ Si02 core-shell nanoprobes for targeted magnetic resonance imaging", NANOSCALE, vol. 5, 2013, pages 10447 - 54
Attorney, Agent or Firm:
YOON, Eui-Seoup (KR)
Download PDF: