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Title:
BIOSENSOR BASED ON TWO-CARBONIZED THREE-TITANIUM TWO-DIMENSIONAL METAL CARBIDE CATALYZED LUMINOL ELECTROCHEMILUMINESCENT PROBE, AND PREPARATION METHOD
Document Type and Number:
WIPO Patent Application WO/2019/200921
Kind Code:
A1
Abstract:
Provided is a biosensor based on a two-carbonized three-titanium two-dimensional metal carbide catalyzed luminol electrochemiluminescent (ECL) probe; said biosensor comprises a probe and a biosensor electrode; said probe comprises nanosheet Ti3C2 MXenes, a linker molecule, and a biorecognition molecule 1; said nanosheet Ti3C2 MXenes are connected to the linker molecule by means of electrostatic adsorption; the linker molecule is connected to the biorecognition molecule 1 by means of an amide group; the linker molecule contains a primary amine group or a secondary amine group, and the linker molecule may carry a positive electric charge after being dissolved in water; the biorecognition molecule 1 is a single-stranded DNA sequence 1 having a carboxyl group at the 5' end; said single-stranded DNA sequence 1 is capable of recognizing the CD63 protein on the exosomes. Also provided is a method for preparing the described sensor. The electrochemiluminescence of luminol is improved by using the Ti3C2 MXenes, and that property is used to prepare same into a probe and thus prepare a biosensor.

Inventors:
WANG, Zonghua (No. 7 Hongkong East Road, Laoshan DistrictQingdao, Shandong 1, 266061, CN)
ZHANG, Huixin (No. 7 Hongkong East Road, Laoshan DistrictQingdao, Shandong 1, 266061, CN)
LIU, Yang (No. 7 Hongkong East Road, Laoshan DistrictQingdao, Shandong 1, 266061, CN)
Application Number:
CN2018/117512
Publication Date:
October 24, 2019
Filing Date:
November 26, 2018
Export Citation:
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Assignee:
QINGDAO UNIVERSITY (No. 7 Hongkong East Road, Laoshan DistrictQingdao, Shandong 1, 266061, CN)
International Classes:
G01N21/76
Domestic Patent References:
WO2015132764A12015-09-11
WO2016012275A12016-01-28
Foreign References:
CN108562573A2018-09-21
US20170067167A12017-03-09
US20170059514A12017-03-02
US20180102624A12018-04-12
Other References:
HANTANASIRISAKUL, K. ET AL.: "Fabrication of Ti3C2Tx MXene Transparent Thin Films with Tunable Optoelectronic Properties", ADVANCED ELECTRONIC MATERIALS, vol. 6, no. 2, 30 June 2016 (2016-06-30)
Attorney, Agent or Firm:
JINAN SHENGDA INTELLECTUAL PROPERTY AGENCY CO., LTD (Room 308, Block B Huate Square,No. 17703, Jingshi Road, Jinan Shandong 1, 250061, CN)
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