BIOSENSOR, METHOD FOR DETECTING BIOMOLECULES, AND BIOCHIP

WIPO Patent Application WO/2017/082227

A1

The present invention provides a biosensor for detecting biomolecules in a specimen with high accuracy and high sensitivity. The present invention is a biosensor for detecting biomolecules in a specimen, wherein the biosensor is provided with a substrate, a magnetoresistance element in which the detected resistance value changes in accordance with the orientation of an inputted magnetic field, a soft-magnetic thin film disposed adjacent to the magnetoresistance element, and a protective film for covering the surface of the soft-magnetic thin film. The protective film is provided with a first affinity substance for recognizing biomolecules on the external surface of the protective film. The soft-magnetic thin film has: a function for changing the direction of a magnetic field (applied magnetic field) applied in substantially the direction of a normal to a laminated surface, and generating a magnetic-field component in the direction of the magnetic sensitivity of the magnetoresistance element as a leakage magnetic field (detection magnetic field) on the laminated-surface end part of the soft-magnetic thin film; and a function for transmitting to the magnetoresistance element a laminated-surface-inward component of a stray magnetic field from magnetic beads collected on the soft-magnetic thin film.

HARATANI SUSUMU (JP)
TSUBOIKE SACHIO (JP)

PCT/JP2016/083024

May 18, 2017

November 08, 2016

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TDK CORP (JP)

G01N27/72; C12M1/00; C12Q1/00; C12Q1/68

US8400146B2	2013-03-19
JP2005513475A	2005-05-12
JPS4994399A	1974-09-07
JP2012507735A	2012-03-29
US20140228227A1	2014-08-14

TANAI Sumio et al. (JP)

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