Title:
BIOSENSORS FOR MEASURING METASTATIC POTENTIAL AND CHEMORESISTANCE OF SINGLE CANCER CELLS
Document Type and Number:
WIPO Patent Application WO/2019/222071
Kind Code:
A3
Abstract:
The present invention provides a Fluorescence Resonance Energy Transfer (FRET) biosensor that measures the metastatic potential and/or chemoresistance of single living cancer cells, and/or cells associated with fibrogenesis, diabetes, aging, and/or infertility.
Inventors:
GHOSH PRADIPTA (US)
Application Number:
PCT/US2019/031954
Publication Date:
August 13, 2020
Filing Date:
May 13, 2019
Export Citation:
Assignee:
UNIV CALIFORNIA (US)
International Classes:
C07K19/00; C07K14/435; C12Q1/02; G01N21/64; G01N33/48; G01N33/53; G01N33/533
Domestic Patent References:
| WO2013016465A1 | 2013-01-31 | |||
| WO2018156697A1 | 2018-08-30 |
Foreign References:
| US20180104307A1 | 2018-04-19 |
Other References:
GETZ, M. ET AL.: "A predictive compoutational model reveals that GIV/Girdin, serves as a tunable valve for EGFR-stimulated cyclic AMP signals", MOLECULAR BIOLOGY OF THE CELL, vol. 30, no. 13, 13 June 2019 (2019-06-13), pages 1621 - 1633, XP055730159, DOI: 10.1091/mbc.E18-10-0630
MIDDE, K. ET AL.: "Single- Cell Imaging of Metastatic Potential of Cancer Cells", ISCIENCE, vol. 10, 21 December 2018 (2018-12-21), pages 53 - 65, XP055730162, DOI: 10.1016/j.isci.2018.11.022
MIDDE, K. ET AL.: "Single- Cell Imaging of Metastatic Potential of Cancer Cells", ISCIENCE, vol. 10, 21 December 2018 (2018-12-21), pages 53 - 65, XP055730162, DOI: 10.1016/j.isci.2018.11.022
Attorney, Agent or Firm:
WARREN, William, L. et al. (US)
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