Title:
BIOSYNTHETIC PATHWAYS AND PRODUCTS
Document Type and Number:
WIPO Patent Application WO/2014/172596
Kind Code:
A3
Abstract:
This disclosure describes biosynthesized compounds including anhydromevalonolactone and β-methyl-δ-valerolactone. This disclosure further describes biosynthetic methods for making these compounds. In some embodiments, the biosynthetic methods can include a combination of biosynthesis and chemical steps to produce β-methyl-δ-valerolactone. Finally, this disclosure described recombinant cells useful for the biosynthesis of these compounds.
Inventors:
ZHANG KECHUN (US)
XIONG MINGYONG (US)
XIONG MINGYONG (US)
Application Number:
PCT/US2014/034588
Publication Date:
January 08, 2015
Filing Date:
April 18, 2014
Export Citation:
Assignee:
UNIV MINNESOTA (US)
International Classes:
C12P17/18; C07D309/38
Other References:
JUNTIRA PUNYA ET AL: "Functional expression of a foreign gene in Aspergillus oryzae producing new pyrone compounds", FUNGAL GENETICS AND BIOLOGY, vol. 50, 1 January 2013 (2013-01-01), pages 55 - 62, XP055127476, ISSN: 1087-1845, DOI: 10.1016/j.fgb.2012.10.005
NANGIA A ET AL: "FACILE SYNTHESIS OF ANHYDROMEVALONOLACTONE FROM ETHYL ACETOACETATE", SYNTHETIC COMMUNICATIONS, vol. 22, no. 4, 1992, pages 593 - 602, XP009178971, ISSN: 0039-7911
WATTANACHAISAEREEKUL, S: "Assessing medium constituents for optimal heterologous production of anhydromevalonolactone in recombinant Aspergillus oryzae", AMB EXPRESS, vol. 4, June 2014 (2014-06-01), pages 1 - 16, XP002726875, Retrieved from the Internet
NANGIA A ET AL: "FACILE SYNTHESIS OF ANHYDROMEVALONOLACTONE FROM ETHYL ACETOACETATE", SYNTHETIC COMMUNICATIONS, vol. 22, no. 4, 1992, pages 593 - 602, XP009178971, ISSN: 0039-7911
WATTANACHAISAEREEKUL, S: "Assessing medium constituents for optimal heterologous production of anhydromevalonolactone in recombinant Aspergillus oryzae", AMB EXPRESS, vol. 4, June 2014 (2014-06-01), pages 1 - 16, XP002726875, Retrieved from the Internet
Attorney, Agent or Firm:
GRAM, Christopher, D. (Raasch & Gebhardt P.A.,P.O. Box 58133, Minneapolis MN, US)
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