Title:
BIOTIN ALTERANT, STREPTAVIDIN MUTANT, AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2014/129446
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a streptavidin mutant having reduced affinity for natural biotin, and to provide a biotin alterant having high affinity for the streptavidin mutant having low affinity for natural biotin. The present invention provides a reagent kit for use in treatment or diagnosis, the reagent kit containing (a) a streptavidin mutant having reduced affinity for natural biotin or biocytin, and (b) a biotin alterant having high affinity for the streptavidin mutant.
Inventors:
SUGIYAMA AKIRA (JP)
DOI HIROFUMI (JP)
KODAMA TATSUHIKO (JP)
INOUE TSUYOSHI (JP)
MIZOHATA EIICHI (JP)
KAWATO TATSUYA (JP)
MESHIZUKA TOMOHIRO (JP)
KANAI MOTOMU (JP)
SHIMIZU YOHEI (JP)
YAMAMOTO TOMOHIRO (JP)
DOI HIROFUMI (JP)
KODAMA TATSUHIKO (JP)
INOUE TSUYOSHI (JP)
MIZOHATA EIICHI (JP)
KAWATO TATSUYA (JP)
MESHIZUKA TOMOHIRO (JP)
KANAI MOTOMU (JP)
SHIMIZU YOHEI (JP)
YAMAMOTO TOMOHIRO (JP)
Application Number:
PCT/JP2014/053734
Publication Date:
August 28, 2014
Filing Date:
February 18, 2014
Export Citation:
Assignee:
SAVID THERAPEUTICS INC (JP)
International Classes:
C07D495/04; C07D497/04; C07D498/04; C07K14/36; C12N15/09; G01N33/53
Domestic Patent References:
| WO2010095455A1 | 2010-08-26 | |||
| WO2012023579A1 | 2012-02-23 | |||
| WO2010095455A1 | 2010-08-26 | |||
| WO2010009455A2 | 2010-01-21 |
Foreign References:
| JPH09506594A | 1997-06-30 | |||
| JP2008530565A | 2008-08-07 | |||
| JPS58154508A | 1983-09-14 | |||
| JP2001514524A | 2001-09-11 | |||
| JPH1028589A | 1998-02-03 | |||
| US5608060A | 1997-03-04 |
Other References:
RYUICHI YASUGI ET AL.: "Biotin", IWANAMI SEIBUTSUGAKU JITEN, 10 April 1997 (1997-04-10), pages 1133, XP008182030
DATABASE REGISTRY 14 April 2009 (2009-04-14), XP055300019, retrieved from STN Database accession no. 1134348-37-0
DATABASE CAPLUS 1993, MIYAMOTO, S. ET AL.: "ABOSLUTE AND RELATIVE BINDING FREE ENERGY CALCULATIONS OF THE INTERACTION OF BIOTIN AND ITS ANALOGS WITH STREPTAVIDIN USING MOLECULAR DYNAMICS/FREE ENERGY PERTURBATION APPROACHES, PROTEINS: STRUCTURE, FUNCTION, AND GENETICS", XP055300024, retrieved from STN Database accession no. 1994:72808
DATABASE REGISTRY 16 November 1984 (1984-11-16), XP055300029, retrieved from STN Database accession no. 66513-70-0
DATABASE REGISTRY 16 November 1984 (1984-11-16), XP055300034, retrieved from STN Database accession no. 76985-52-9
DATABASE FILE REGISTRY 16 November 1984 (1984-11-16), XP055300038, retrieved from STN Database accession no. 39871-28-8
GREEN, ADV. PROTEIN CHEM., vol. 29, 1975, pages 85 - 133
GREEN, METHODS ENZYMOL., vol. 184, 1990, pages 51 - 67
HNATOWICH, J. NUCL. MED., vol. 28, 1987, pages 1294 - 1302
PAGANELLI, CANCER RES., vol. 51, 1991, pages 5960 - 5966
MULLIGAN ET AL., NATURE, vol. 277, 1979, pages 108
MIZUSHIMA ET AL., NUCLEIC ACIDS RES., vol. 18, 1990, pages 5322
DATABASE REGISTRY 14 April 2009 (2009-04-14), XP055300019, retrieved from STN Database accession no. 1134348-37-0
DATABASE CAPLUS 1993, MIYAMOTO, S. ET AL.: "ABOSLUTE AND RELATIVE BINDING FREE ENERGY CALCULATIONS OF THE INTERACTION OF BIOTIN AND ITS ANALOGS WITH STREPTAVIDIN USING MOLECULAR DYNAMICS/FREE ENERGY PERTURBATION APPROACHES, PROTEINS: STRUCTURE, FUNCTION, AND GENETICS", XP055300024, retrieved from STN Database accession no. 1994:72808
DATABASE REGISTRY 16 November 1984 (1984-11-16), XP055300029, retrieved from STN Database accession no. 66513-70-0
DATABASE REGISTRY 16 November 1984 (1984-11-16), XP055300034, retrieved from STN Database accession no. 76985-52-9
DATABASE FILE REGISTRY 16 November 1984 (1984-11-16), XP055300038, retrieved from STN Database accession no. 39871-28-8
GREEN, ADV. PROTEIN CHEM., vol. 29, 1975, pages 85 - 133
GREEN, METHODS ENZYMOL., vol. 184, 1990, pages 51 - 67
HNATOWICH, J. NUCL. MED., vol. 28, 1987, pages 1294 - 1302
PAGANELLI, CANCER RES., vol. 51, 1991, pages 5960 - 5966
MULLIGAN ET AL., NATURE, vol. 277, 1979, pages 108
MIZUSHIMA ET AL., NUCLEIC ACIDS RES., vol. 18, 1990, pages 5322
Attorney, Agent or Firm:
SIKs & Co. (JP)
Patent business corporation patent firm Sykes (JP)
Patent business corporation patent firm Sykes (JP)
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