Title:
BIOTIN-MODIFIED DIMER AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/210573
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a novel halogenated biotin-modified dimer to enable imaging diagnosis or treatment. The present invention provides a compound represented by formula (1) or a salt thereof. (In the formula, L1 represents a trivalent linking group, L2 represents a divalent linking group, Hal represents a halogen element, p represents an integer of 1-5, and q, r, s, and t each independently represent an integer of 1-8.)
Inventors:
KANAI MOTOMU (JP)
YAMATSUGU KENZO (JP)
TATSUMI TOSHIFUMI (JP)
KODAMA TATSUHIKO (JP)
SUGIYAMA AKIRA (JP)
TSUKAGOSHI MASANOBU (JP)
TODA YUZO (JP)
WASHIYAMA KOHSHIN (JP)
TAKAHASHI KAZUHIRO (JP)
ZHAO SONGJI (JP)
UKON NAOYUKI (JP)
SUZUKI MIHO (JP)
YAMATSUGU KENZO (JP)
TATSUMI TOSHIFUMI (JP)
KODAMA TATSUHIKO (JP)
SUGIYAMA AKIRA (JP)
TSUKAGOSHI MASANOBU (JP)
TODA YUZO (JP)
WASHIYAMA KOHSHIN (JP)
TAKAHASHI KAZUHIRO (JP)
ZHAO SONGJI (JP)
UKON NAOYUKI (JP)
SUZUKI MIHO (JP)
Application Number:
PCT/JP2021/015299
Publication Date:
October 21, 2021
Filing Date:
April 13, 2021
Export Citation:
Assignee:
UNIV TOKYO (JP)
SAVID THERAPEUTICS INC (JP)
UNIV FUKUSHIMA MEDICAL (JP)
SAVID THERAPEUTICS INC (JP)
UNIV FUKUSHIMA MEDICAL (JP)
International Classes:
A61P35/00; A61K47/66; A61K47/68; A61K51/04; A61K51/10; C07D519/00; G01N33/53
Domestic Patent References:
| WO2019230905A1 | 2019-12-05 | |||
| WO2015125820A1 | 2015-08-27 | |||
| WO2018151301A1 | 2018-08-23 | |||
| WO2019189867A1 | 2019-10-03 | |||
| WO2020032165A1 | 2020-02-13 | |||
| WO2010095455A1 | 2010-08-26 | |||
| WO2014129446A1 | 2014-08-28 | |||
| WO2015125820A1 | 2015-08-27 | |||
| WO2010086398A1 | 2010-08-05 | |||
| WO2019230905A1 | 2019-12-05 | |||
| WO2018007239A1 | 2018-01-11 |
Foreign References:
| US5608060A | 1997-03-04 | |||
| US7626011B2 | 2009-12-01 |
Other References:
SU, Z.YEAGLEY, A. A.SU, R.PENG, L.MELANDER, C, CHEMMEDCMEM, vol. 7, 2012, pages 2030 - 2039
ROY, B. C.MALIK, S, J. ORG. CHEM., vol. 199, no. 64, pages 2969 - 2974
THOMA, G.STREIFF, M. B.KATAPODIS, A. G.DUTHALER, R. O.VOELCKER, N. H.EHRHARDT, C.MASSON, C, CHEM.-EUR. J., vol. 12, 2006, pages 99 - 117
ZALUTSKY MRNARULA AS: "Astatination of proteins using an N-succinimidyl tri-n-butylstannyl benzoate intermediate", INT J RAD APPL INSTRUM A, vol. 39, no. 3, 1988, pages 227 - 32, XP024707312, DOI: 10.1016/0883-2889(88)90176-1
ROY, B. C.MALIK, S, J. ORG. CHEM., vol. 199, no. 64, pages 2969 - 2974
THOMA, G.STREIFF, M. B.KATAPODIS, A. G.DUTHALER, R. O.VOELCKER, N. H.EHRHARDT, C.MASSON, C, CHEM.-EUR. J., vol. 12, 2006, pages 99 - 117
ZALUTSKY MRNARULA AS: "Astatination of proteins using an N-succinimidyl tri-n-butylstannyl benzoate intermediate", INT J RAD APPL INSTRUM A, vol. 39, no. 3, 1988, pages 227 - 32, XP024707312, DOI: 10.1016/0883-2889(88)90176-1
Attorney, Agent or Firm:
SIKS & CO. (JP)
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