Title:
BIOVALVE CROSSLINKING METHOD FOR IMPROVING MECHANICAL AND ANTICOAGULATION PROPERTIES, BIOVALVE MATERIAL AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/121912
Kind Code:
A1
Abstract:
A biovalve crosslinking method for improving mechanical and anticoagulation properties, a biovalve material and an application thereof, relating to the technical field of biomedical materials. In the biovalve crosslinking method, a biomaterial is modified using 3,4-dihydroxybenzaldehyde, and diphenol groups are introduced to the biomaterial and then polymerized and crosslinked with each other, thereby achieving cross-linking immobilization of the biovalve. Compared with conventional glutaraldehyde crosslinking, the method can improve the tensile strength at break, anti-platelet adhesion and anti-coagulation performance of the biomaterial, potentially enhance the biocompatibility of the biomaterial and prolong the service life of the biomaterial.
Inventors:
WANG YUNBING (CN)
ZHENG CHENG (CN)
WU BINGGANG (CN)
LEI YANG (CN)
YANG LI (CN)
ZHENG CHENG (CN)
WU BINGGANG (CN)
LEI YANG (CN)
YANG LI (CN)
Application Number:
PCT/CN2021/136200
Publication Date:
June 16, 2022
Filing Date:
December 07, 2021
Export Citation:
Assignee:
JILIN VENUS HAOYUE MEDICAL LTD (CN)
International Classes:
A61F2/24; A61L27/36; A61L27/50; A61L33/06
Domestic Patent References:
| WO2002060505A2 | 2002-08-08 |
Foreign References:
| CN108498869A | 2018-09-07 | |||
| CN108159482A | 2018-06-15 | |||
| CN112472871A | 2021-03-12 | |||
| CN111569152A | 2020-08-25 | |||
| CN110585486A | 2019-12-20 | |||
| CN111166938A | 2020-05-19 |
Attorney, Agent or Firm:
SHINY INTELLECTUAL PROPERTY FIRM (CN)
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