Title:
BIPHENYL COMPOUNDS AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2015/062486
Kind Code:
A1
Abstract:
The present invention relates to biphenyl compounds and uses thereof in medicine. Specifically, the present invention relates to a compound of Formula (I), or a stereoisomer, a geometric isomer, a tautomer, a mesomer, a racemate, an enantiomer, a diastereoisomer, an N-oxide, a hydrate, a solvate, a metabolite, a hydrolysate, a pharmaceutically acceptable salt or a prodrug thereof. The compound disclosed herein is used as a therapeutic agent particularly a GPR40 agonist for treating diabetes and metabolic disease in a patient.
Inventors:
ZHANG YINGJUN (CN)
WANG XIAOJUN (CN)
YANG XINYE (CN)
PAN SHENGQIANG (CN)
WU CHENLIANG (CN)
MA FACHENG (CN)
WU SHOUTAO (CN)
WU JUNWEN (CN)
WANG XIAOJUN (CN)
YANG XINYE (CN)
PAN SHENGQIANG (CN)
WU CHENLIANG (CN)
MA FACHENG (CN)
WU SHOUTAO (CN)
WU JUNWEN (CN)
Application Number:
PCT/CN2014/089725
Publication Date:
May 07, 2015
Filing Date:
October 28, 2014
Export Citation:
Assignee:
SUNSHINE LAKE PHARMA CO LTD (CN)
International Classes:
C07D405/12; A61K31/397; A61P3/10; C07D307/80; C07D407/12; C07D409/12; C07D413/12
Domestic Patent References:
| WO2008001931A2 | 2008-01-03 | |||
| WO2005087710A1 | 2005-09-22 | |||
| WO2004106276A1 | 2004-12-09 |
Foreign References:
| CN103145663A | 2013-06-12 |
Other References:
NOBUYUKI NEGORO ET AL.: "Optimization of (2, 3-Dihydro-1-benzofuran-3-yl)acetic Acids: Discovery of a Non-Free Fatty Acid-Like, Highly Bioavailable G Protein-Coupled Receptor 40/Free Fatty Acid Receptor 1 Agonist as a Glucose-Dependent Insulinotropic Agent", J. MED. CHEM., vol. 55, no. 8, 10 April 2012 (2012-04-10), pages 3965, XP002744049, DOI: doi:10.1021/jm300170m
Attorney, Agent or Firm:
TSINGYIHUA INTELLECTUAL PROPERTY LLC (Trade Building Zhaolanyuan, Tsinghua University,Qinghuayuan, Haidian District, Beijing 4, CN)
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