Title:
BIPHENYLACETAMIDE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2010/055911
Kind Code:
A1
Abstract:
A compound represented by formula (I) or a salt thereof, which is useful as an agent for treatment or prevention of various epileptic seizures, namely partial seizures and/or generalized seizures.
(In the formula, R1, R2 and R3 may be the same or different and each represents a hydrogen atom, a fluorine atom, a chlorine atom, a bromine atom, a C1-6 alkyl, a C1-6 alkoxy substituted by a fluorine atom, or the like; R4 and R5 may be the same or different and each represents a hydrogen atom, a fluorine atom, a chlorine atom, a C1-6 alkyl, a C1-6 alkoxy substituted by a fluorine atom, or the like; R6 and R7 may be the same or different and each represents a hydrogen atom, a fluorine atom, a methyl, an ethyl, a hydroxyl group, or the like; and R8 and R9 may be the same or different and each represents a hydrogen atom, a C1-6 alkyl or the like.)
Inventors:
IWAMA SEIJI (JP)
TANAKA TOMOYUKI (JP)
YAJIMA NANA (JP)
TANAKA TOMOYUKI (JP)
YAJIMA NANA (JP)
Application Number:
PCT/JP2009/069355
Publication Date:
May 20, 2010
Filing Date:
November 13, 2009
Export Citation:
Assignee:
DAINIPPON SUMITOMO PHARMA CO (JP)
IWAMA SEIJI (JP)
TANAKA TOMOYUKI (JP)
YAJIMA NANA (JP)
IWAMA SEIJI (JP)
TANAKA TOMOYUKI (JP)
YAJIMA NANA (JP)
International Classes:
C07C233/11; A61K31/165; A61P25/08; C07C233/58; C07C235/34; C07C255/57; C07C317/44; C07C317/46; C07C323/62
Domestic Patent References:
| WO2005063222A1 | 2005-07-14 | |||
| WO2009013963A1 | 2009-01-29 |
Foreign References:
| US4277471A | 1981-07-07 | |||
| US20040254166A1 | 2004-12-16 |
Other References:
MERLIC, C.A. ET AL.: "Aminobenzannulation via metathesis of isonitriles using chromium carbene complexes", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 114, no. 22, 1992, pages 8722 - 4
BRADSHER, C.K. ET AL.: "The cyclization of nitriles: a new route to some phenanthrylamines", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 78, 1956, pages 2153 - 6
BRADSHER, C.K. ET AL.: "Aromatic cyclodehydration. XXVIII. 9, 10-Dialkylphenanthrenes by cyclization of ketones", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 76, 1954, pages 4140 - 3
PAWEL, D.Z ET AL.: "Non-epilepsy use of antiepileptic drugs", PHARMACOLOGICAL REPORTS, vol. 58, 2006, pages 1 - 12
BRAMBILLA, P., BARRALE, F., SOARES, J.C.: "Perspectives on the use of anticonvulsants in the treatment of bipolar disorder", INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, vol. 4, 2001, pages 421 - 446
TETRAHEDRON LETTERS, vol. 27, 1986, pages 6103 - 6106
LOSCHER ET AL., EPILEPSY RES., vol. 40, 2000, pages 63 - 77
MOTOR SEIZURE. ELECTROENCEPH. CLIN. NEUROPHYSIOL., vol. 32, 1972, pages 281 - 294
PORSOLT ET AL., NATURE, vol. 266, 1977, pages 730 - 732
PORSOLT ET AL., EUR. J. PHARMACOL., vol. 47, 1978, pages 379 - 391
ARBAN ET AL., BEHAV. BRAIN RES., vol. 158, 2005, pages 123 - 132
FOREMAN ET AL., PHARMACOL. BIOCHEM. BEHAV., vol. 89, 2008, pages 523 - 534
BRADSHER, C.K. ET AL.: "The cyclization of nitriles: a new route to some phenanthrylamines", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 78, 1956, pages 2153 - 6
BRADSHER, C.K. ET AL.: "Aromatic cyclodehydration. XXVIII. 9, 10-Dialkylphenanthrenes by cyclization of ketones", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 76, 1954, pages 4140 - 3
PAWEL, D.Z ET AL.: "Non-epilepsy use of antiepileptic drugs", PHARMACOLOGICAL REPORTS, vol. 58, 2006, pages 1 - 12
BRAMBILLA, P., BARRALE, F., SOARES, J.C.: "Perspectives on the use of anticonvulsants in the treatment of bipolar disorder", INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, vol. 4, 2001, pages 421 - 446
TETRAHEDRON LETTERS, vol. 27, 1986, pages 6103 - 6106
LOSCHER ET AL., EPILEPSY RES., vol. 40, 2000, pages 63 - 77
MOTOR SEIZURE. ELECTROENCEPH. CLIN. NEUROPHYSIOL., vol. 32, 1972, pages 281 - 294
PORSOLT ET AL., NATURE, vol. 266, 1977, pages 730 - 732
PORSOLT ET AL., EUR. J. PHARMACOL., vol. 47, 1978, pages 379 - 391
ARBAN ET AL., BEHAV. BRAIN RES., vol. 158, 2005, pages 123 - 132
FOREMAN ET AL., PHARMACOL. BIOCHEM. BEHAV., vol. 89, 2008, pages 523 - 534
Attorney, Agent or Firm:
TANAKA, Mitsuo et al. (JP)
Mitsuo Tanaka (JP)
Mitsuo Tanaka (JP)
Download PDF:
Previous Patent: ABSORBENT ARTICLE MANUFACTURING DEVICE AND ABSORBENT ARTICLE MANUFACTURING METHOD
Next Patent: ELECTRONIC CIRCUIT DEVICE
Next Patent: ELECTRONIC CIRCUIT DEVICE