Title:
BIPHENYLS AND FLUORENES AS IMAGING AGENTS IN ALZHEIMER'S DISEASE
Document Type and Number:
WIPO Patent Application WO2004032975
Kind Code:
A3
Abstract:
This invention relates to a method of imaging amyloid deposits and to labeled compounds, and methods of making labeled compounds useful in imaging amyloid deposits. This invention also relates to compounds, and methods of making compounds for inhibiting the aggregation of amyloid proteins to form amyloid deposits, and a method of delevering a therapeutic agent to amyloid deposits.
Inventors:
KUNG HANK F (US)
KUNG MEI PING (US)
ZHUANG ZHI-PING (US)
KUNG MEI PING (US)
ZHUANG ZHI-PING (US)
Application Number:
PCT/US2003/031466
Publication Date:
September 16, 2004
Filing Date:
October 06, 2003
Export Citation:
Assignee:
KUNG HANK F (US)
KUNG MEI PING (US)
ZHUANG ZHI-PING (US)
KUNG MEI PING (US)
ZHUANG ZHI-PING (US)
International Classes:
A61K51/00; A61K51/04; C07C323/25; C07C323/60; C07D231/14; C07D231/16; C07F13/00; (IPC1-7): A61K51/04
Domestic Patent References:
| WO1993024115A1 | 1993-12-09 | |||
| WO1999041224A1 | 1999-08-19 | |||
| WO1998047969A1 | 1998-10-29 |
Foreign References:
| US2157071A | 1939-05-02 | |||
| US3821293A | 1974-06-28 | |||
| AU545825B2 | 1985-08-01 | |||
| US5739166A | 1998-04-14 |
Other References:
LEE C-W ET AL: "Dimethylamino-fluorenes: ligands for detecting beta-amyloid plaques in the brain", NUCLEAR MEDICINE AND BIOLOGY, ELSEVIER SCIENCE PUBLISHERS, NEW YORK, NY, US, vol. 30, no. 6, August 2003 (2003-08-01), pages 573 - 580, XP004444175, ISSN: 0969-8051
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; REISSERT, ARNOLD: "Attempts to prepare substituted indigos", XP002270065, retrieved from STN Database accession no. 8:10644
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; VORLANDER, D.: "The doctrine of intramolecular oppositions and the directing of substituents in benzene. II", XP002270066, retrieved from STN Database accession no. 20:4855
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; THEILACKER, WALTER ET AL: "Dye theory. Triarylmethane dyes of the biphenyl series. II", XP002270004, retrieved from STN Database accession no. 51:17167
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; BARKER, C. C. ET AL: "Steric effects in di- and triarylmethanes. VII. Biphenyl analogs of crystal violet and malachite green", XP002270067, retrieved from STN Database accession no. 56:18064
KLUNK W E ET AL: "DEVELOPMENT OF SMALL MOLECULE PROBES FOR THE BETA-AMYLOID PROTEIN OF ALZHEIMER'S DISEASE", NEUROBIOLOGY OF AGING, TARRYTOWN, NY, US, vol. 15, no. 6, 1994, pages 691 - 698, XP000602786, ISSN: 0197-4580
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; REISSERT, ARNOLD: "Attempts to prepare substituted indigos", XP002270065, retrieved from STN Database accession no. 8:10644
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; VORLANDER, D.: "The doctrine of intramolecular oppositions and the directing of substituents in benzene. II", XP002270066, retrieved from STN Database accession no. 20:4855
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; THEILACKER, WALTER ET AL: "Dye theory. Triarylmethane dyes of the biphenyl series. II", XP002270004, retrieved from STN Database accession no. 51:17167
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; BARKER, C. C. ET AL: "Steric effects in di- and triarylmethanes. VII. Biphenyl analogs of crystal violet and malachite green", XP002270067, retrieved from STN Database accession no. 56:18064
KLUNK W E ET AL: "DEVELOPMENT OF SMALL MOLECULE PROBES FOR THE BETA-AMYLOID PROTEIN OF ALZHEIMER'S DISEASE", NEUROBIOLOGY OF AGING, TARRYTOWN, NY, US, vol. 15, no. 6, 1994, pages 691 - 698, XP000602786, ISSN: 0197-4580
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