Title:
BIPYRIDINE MANGANESE COMPLEXES
Document Type and Number:
WIPO Patent Application WO2000009512
Kind Code:
A3
Abstract:
Compounds and methods of preparing compounds represented by structural formula (I) wherein X represents any suitable counter-anion; R<1> and R<2> independently represent hydrogen, C1-6 alkoxy or nitro; R<3>, R<4>, R<5> and R<6> each independently represents hydrogen, hydroxy, halo, C1-6 alkyl, C2-6 alkenyl or C1-6 alkoxy; and R<7>, R<8>, R<9> and R<10> each independently represents hydrogen, hydroxy, halo, C1-6 alkyl, C2-6 alkenyl or C1-6 alkoxy. Compounds represented by structural formula (I) are useful in treating or preventing free radical-associated diseases or conditions in mammals.
Inventors:
CAMPBELL IAN BAXTER
WALKER ANN LOUISE
BOX PHILIP CHARLES
GIBLIN GERARD MARTIN PAUL
TRANTER GEORGE EDWARD
WALKER ANN LOUISE
BOX PHILIP CHARLES
GIBLIN GERARD MARTIN PAUL
TRANTER GEORGE EDWARD
Application Number:
PCT/US1999/018629
Publication Date:
May 31, 2001
Filing Date:
August 17, 1999
Export Citation:
Assignee:
EUKARION INC (US)
International Classes:
A61K31/4402; A61K31/4418; A61K31/444; A61K33/32; C07D213/38; A61P1/00; A61P1/02; A61P1/18; A61P9/00; A61P9/10; A61P9/12; A61P11/00; A61P11/02; A61P11/06; A61P17/00; A61P17/04; A61P17/06; A61P19/02; A61P25/00; A61P25/08; A61P25/16; A61P25/28; A61P27/00; A61P27/12; A61P31/18; A61P35/00; A61P37/06; A61P37/08; A61P39/04; A61P39/06; C07C53/10; C07D213/53; C07F5/02; C07F5/04; C07F13/00; (IPC1-7): C07F13/00; C07F5/04; C07D213/53; A61K33/32
Domestic Patent References:
| WO1997032853A1 | 1997-09-12 | |||
| WO1994027949A1 | 1994-12-08 |
Foreign References:
| US5696109A | 1997-12-09 |
Other References:
CAPDEVIELLE, P. ET AL: "Electroactive polymers exchanging transition metal ions;synthesis of new monomers and polymers based on 6,6'-bis(2- hydroxyphenyl)bipyridine complexes", NEW J. CHEM. (1994), 18(4), 519-24, XP002121132
BENAGLIA, MAURIZIO ET AL: "Synthesis of pyridylstannanes from halopyridines and hexamethyldistannane with catalytic palladium", TETRAHEDRON LETT. ( 1997 ), 38(27), 4737-4740, XP002119996
UENISHI, JUNICHI ET AL: "Ipso Substitution of 2-alkylsulfinylpyridine by 2-pyridyllithium;a new preparation of oligopyridine and their bromomethyl derivatives", TETRAHEDRON LETT. (1990), 31(32), 4625-8, XP002119997
CONSTABLE, EDWIN C. ET AL: "A novel rearrangement of 2,2'-bipyridine N,N'-dioxides. The characterization of dipyrido[1,2-b:2,3-d]isoxazolinium salts as intermediates in the formation of 3-hydroxy-2,2'-bipyridines", TETRAHEDRON (1983), 39(2), 291-5, XP002119998
NEUMANN, UWE ET AL: "4,4'-Donor-substituted and 6,6'-difunctionalized 2,2'-bipyridines", CHEM. BER. (1989), 122(3), 589-91, XP002119999
BENAGLIA, MAURIZIO ET AL: "Synthesis of pyridylstannanes from halopyridines and hexamethyldistannane with catalytic palladium", TETRAHEDRON LETT. ( 1997 ), 38(27), 4737-4740, XP002119996
UENISHI, JUNICHI ET AL: "Ipso Substitution of 2-alkylsulfinylpyridine by 2-pyridyllithium;a new preparation of oligopyridine and their bromomethyl derivatives", TETRAHEDRON LETT. (1990), 31(32), 4625-8, XP002119997
CONSTABLE, EDWIN C. ET AL: "A novel rearrangement of 2,2'-bipyridine N,N'-dioxides. The characterization of dipyrido[1,2-b:2,3-d]isoxazolinium salts as intermediates in the formation of 3-hydroxy-2,2'-bipyridines", TETRAHEDRON (1983), 39(2), 291-5, XP002119998
NEUMANN, UWE ET AL: "4,4'-Donor-substituted and 6,6'-difunctionalized 2,2'-bipyridines", CHEM. BER. (1989), 122(3), 589-91, XP002119999
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