BIS-ALKOXYL AMIDE ALKYL CATIONIC PEPTIDE LIPIDS, SYNTHESIS METHOD THEREOF, AND APPLICATION THEREOF

Title:

BIS-ALKOXYL AMIDE ALKYL CATIONIC PEPTIDE LIPIDS, SYNTHESIS METHOD THEREOF, AND APPLICATION THEREOF

Document Type and Number:

WIPO Patent Application WO/2016/192149

Kind Code:

A1

Abstract:

A class of bis-alkoxyl amide alkyl cationic peptide lipids has a chemical structural formula: . After the bis-alkoxyl amide alkyl cationic peptide lipids are dispersed in water, a cationic peptide liposome that has desirable stability, uniform dispersion, an average particle size of approximately 120 nm, and a Zeta potential of 30 mV to 50 mV can be obtained. The liposome is capable of effectively compressing plasmid DNA and siRNA, can realize efficient transfection both in vitro and in vivo, and almost does not produce toxicity to cells and mice, so that the liposome is widely applied to gene delivery as a gene carrier.

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Inventors:

ZHANG SHUBIAO (CN)
ZHAO YINAN (CN)
CUI SHAOHUI (CN)
CHEN HUIYING (CN)
ZHOU QUAN (CN)

Application Number:

PCT/CN2015/082260

Publication Date:

December 08, 2016

Filing Date:

June 25, 2015

Export Citation:

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Assignee:

UNIV NAT DALIAN (CN)

International Classes:

C07K5/11; C07K1/06; C12N15/87

Domestic Patent References:

WO1996001840A1

1996-01-25

Foreign References:

CN103613516A	2014-03-05
CN102006890A	2011-04-06

Other References:

ZHAO, YINAN ET AL.: "Tri-peptide cationic lipids for gene delivery", JOURNAL OF MATERIALS CHEMISTRY B, 30 September 2014 (2014-09-30), pages 119 - 126, XP055332515

Attorney, Agent or Firm:

DALIAN YITONG PATENT OFFICE(COMMON PARTNERSHIP) (CN)
大连一通专利代理事务所(普通合伙） (CN)

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