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Title:
BISARYL COMPOUNDS AND CANCER REMEDIES CONTAINING THE SAME
Document Type and Number:
WIPO Patent Application WO/1998/052551
Kind Code:
A1
Abstract:
Cancer remedies, each containing a compound of the following general formula (I): Ar?1�-S-R?1�-S-Ar?2� [wherein RP represents a non-metallic connecting group; Ar?1� and Ar?2� each independently represents aryl or heteroaryl having 1 to 3 hydroxyls which may be substituted with a monovalent group on the ring thereof (and optionally having 1 to 3 substituents other than the hydroxyl on the ring thereof)] or a physiologically acceptable salt thereof; and compounds of the following general formula (XII): Ar?23�-S-R?22�-N(R?24�)-R?23�-S-Ar?24� [wherein R?22� and R?23� each independently represents a divalent group; R?24� represents a monovalent group or atom, or R?24� may be bonded to R?22� and/or R?23� to form a cyclic structure and further bonded to one or two C�1-4? alkylene groups to form a divalent group; and Ar?23� and Ar?24� each independently represents aryl or heteroaryl (optionally having 1 to 3 substituents other than hydroxyl on the ring thereof) having 1 to 3 hydroxyls which may be substituted with a monovalent group; excluding specified compounds] and salts thereof.

Inventors:
Yonetani, Yoshiyuki (2-2-2, Miwamidoriyama Machida-shi, Tokyo, 195-0055, JP)
Takahashi, Takeshi (542-1, Honjuku Nagaizumi-ch, Sunto-gun Shizuoka, 411-0945, JP)
Okada, Yuko (4-17-9, Morino Machida-shi, Tokyo, 194-0022, JP)
Mizukami, Tamio (2141-69, Honmachida Machida-shi, Tokyo, 194-0032, JP)
Tamaoki, Tatsuya (2662-13, Honmachida Machida-shi, Tokyo, 194-0032, JP)
Ikeda, Shun-ichi (1-6-2, Sunamichi-cho Sakai-shi, Osaka, 590-0002, JP)
Takashima, Masanobu (Fuji Photo Film Co. Ltd, Fujinomiya Research Laboratories, 200, Ohnakazat, Fujinomiya-shi Shizuoka, 418-8666, JP)
Asanuma, Naoki (Fuji Photo Film Co. Ltd, Ashigara Research Laboratories, 210, Nakanum, Minami-ashigara-shi Kanagawa, 250-0123, JP)
Inaba, Tadashi (Fuji Photo Film Co. Ltd, Ashigara Research Laboratories, 210, Nakanum, Minami-ashigara-shi Kanagawa, 250-0123, JP)
Takeuchi, Hiroshi (Fuji Photo Film Co. Ltd, Ashigara Research Laboratories, 210, Nakanum, Minami-ashigara-shi Kanagawa, 250-0123, JP)
Kawamoto, Hiroshi (Fuji Photo Film Co. Ltd, Ashigara Research Laboratories, 210, Nakanum, Minami-ashigara-shi Kanagawa, 250-0123, JP)
Tsukada, Yoshihisa (Fuji Photo Film Co. Ltd, Ashigara Research Laboratories, 210, Nakanum, Minami-ashigara-shi Kanagawa, 250-0123, JP)
Satomura, Masato (Fuji Photo Film Co. Ltd, Ashigara Research Laboratories, 210, Nakanum, Minami-ashigara-shi Kanagawa, 250-0123, JP)
Kitaguchi, Hiroshi (Fuji Photo Film Co. Ltd, Ashigara Research Laboratories, 210, Nakanum, Minami-ashigara-shi Kanagawa, 250-0123, JP)
Application Number:
PCT/JP1998/002242
Publication Date:
November 26, 1998
Filing Date:
May 21, 1998
Export Citation:
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Assignee:
KYOWA HAKKO KOGYO CO., LTD. (6-1 Otemachi 1-chome, Chiyoda-ku, Tokyo, 100-8185, JP)
FUJI PHOTO FILM CO., LTD. (210 Nakanuma, Minami-ashigara-shi, Kanagawa, 250-0123, JP)
Yonetani, Yoshiyuki (2-2-2, Miwamidoriyama Machida-shi, Tokyo, 195-0055, JP)
Takahashi, Takeshi (542-1, Honjuku Nagaizumi-ch, Sunto-gun Shizuoka, 411-0945, JP)
Okada, Yuko (4-17-9, Morino Machida-shi, Tokyo, 194-0022, JP)
Mizukami, Tamio (2141-69, Honmachida Machida-shi, Tokyo, 194-0032, JP)
Tamaoki, Tatsuya (2662-13, Honmachida Machida-shi, Tokyo, 194-0032, JP)
Ikeda, Shun-ichi (1-6-2, Sunamichi-cho Sakai-shi, Osaka, 590-0002, JP)
Takashima, Masanobu (Fuji Photo Film Co. Ltd, Fujinomiya Research Laboratories, 200, Ohnakazat, Fujinomiya-shi Shizuoka, 418-8666, JP)
Asanuma, Naoki (Fuji Photo Film Co. Ltd, Ashigara Research Laboratories, 210, Nakanum, Minami-ashigara-shi Kanagawa, 250-0123, JP)
Inaba, Tadashi (Fuji Photo Film Co. Ltd, Ashigara Research Laboratories, 210, Nakanum, Minami-ashigara-shi Kanagawa, 250-0123, JP)
Takeuchi, Hiroshi (Fuji Photo Film Co. Ltd, Ashigara Research Laboratories, 210, Nakanum, Minami-ashigara-shi Kanagawa, 250-0123, JP)
Kawamoto, Hiroshi (Fuji Photo Film Co. Ltd, Ashigara Research Laboratories, 210, Nakanum, Minami-ashigara-shi Kanagawa, 250-0123, JP)
Tsukada, Yoshihisa (Fuji Photo Film Co. Ltd, Ashigara Research Laboratories, 210, Nakanum, Minami-ashigara-shi Kanagawa, 250-0123, JP)
Satomura, Masato (Fuji Photo Film Co. Ltd, Ashigara Research Laboratories, 210, Nakanum, Minami-ashigara-shi Kanagawa, 250-0123, JP)
Kitaguchi, Hiroshi (Fuji Photo Film Co. Ltd, Ashigara Research Laboratories, 210, Nakanum, Minami-ashigara-shi Kanagawa, 250-0123, JP)
International Classes:
A61P35/00; C07C323/16; C07C323/25; C07C323/40; C07D207/08; C07D211/58; C07D211/60; C07D213/32; C07D215/06; C07D233/54; C07D233/61; C07D239/42; C07D239/58; C07D251/38; C07D277/44; C07D277/56; C07D309/38; C07D317/22; C07D317/28; C07D319/06; C07H5/06; C07H15/18; (IPC1-7): A61K31/10; A61K31/11; A61K31/12; A61K31/135; A61K31/155; A61K31/165; A61K31/18; A61K31/19; A61K31/215; A61K31/335; A61K31/34; A61K31/35; A61K31/40; A61K31/44; A61K31/445; A61K31/47; A61K31/495; A61K31/505; A61K31/70; C07D207/08; C07D207/408; C07D211/22; C07D213/32; C07D215/08; C07D233/61; C07D239/10; C07D239/58; C07D241/18; C07D251/38; C07D277/44; C07D295/12; C07D295/18; C07D295/22; C07D307/66; C07D309/04; C07D309/08; C07D309/30; C07D309/38; C07D317/22; C07D317/28; C07D319/06; C07D333/20; C07D521/00; C07H15/18
Domestic Patent References:
1998-01-29
1996-02-15
Foreign References:
JPH03182393A1991-08-08
US4612393A1986-09-16
DE3541234A11986-05-28
EP0140297A21985-05-08
EP0119160A11984-09-19
CA1157774A11983-11-29
US4282242A1981-08-04
FR1507899A1967-12-29
Other References:
CAI JUN CHAO et al., "Synthesis and Antitumor Properties of N1-(Acyloxy)Methyl Derivatives of Bis(2,6-Dioxopiperazines)", CHEM. PHARM. BULL., 1989, Vol. 37, No. 11, pages 2976-2983, XP002917464
MOTOHASHI NOBORU, "Test for Antitumor Activities of Phenothiazines and Phenoxazines", YAKUGAKU ZASSHI, 1983, Vol. 103, No. 3, pages 364-371, XP002917465
DATABASE CAPLUS ON STN, AMERICAN CHEMICAL SOCIETY (ACS), (Columbus, Ohio, USA), AN. 117-112193, KRICHELDORF HANS R. et al., "New Polymer Syntheses. 55. Aromatic Poly(Ether Sulfides) of Pyridine and Pyridazine", XP002917466; & POLYM. BULL., 1992, Vol. 28, No. 4, pages 411-418.
See also references of EP 0990439A1
Attorney, Agent or Firm:
Imamura, Masazumi . (KRF Building, 5th floor 5-5, Kyobashi 1-chom, Chuo-ku Tokyo, 104-0031, JP)
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