Title:
BISARYL COMPOUNDS AND CANCER REMEDIES CONTAINING THE SAME
Document Type and Number:
WIPO Patent Application WO/1998/052551
Kind Code:
A1
Abstract:
Cancer remedies, each containing a compound of the following general formula (I): Ar?1�-S-R?1�-S-Ar?2� [wherein RP represents a non-metallic connecting group; Ar?1� and Ar?2� each independently represents aryl or heteroaryl having 1 to 3 hydroxyls which may be substituted with a monovalent group on the ring thereof (and optionally having 1 to 3 substituents other than the hydroxyl on the ring thereof)] or a physiologically acceptable salt thereof; and compounds of the following general formula (XII): Ar?23�-S-R?22�-N(R?24�)-R?23�-S-Ar?24� [wherein R?22� and R?23� each independently represents a divalent group; R?24� represents a monovalent group or atom, or R?24� may be bonded to R?22� and/or R?23� to form a cyclic structure and further bonded to one or two C�1-4? alkylene groups to form a divalent group; and Ar?23� and Ar?24� each independently represents aryl or heteroaryl (optionally having 1 to 3 substituents other than hydroxyl on the ring thereof) having 1 to 3 hydroxyls which may be substituted with a monovalent group; excluding specified compounds] and salts thereof.
Inventors:
YONETANI YOSHIYUKI (JP)
TAKAHASHI TAKESHI (JP)
OKADA YUKO (JP)
MIZUKAMI TAMIO (JP)
TAMAOKI TATSUYA (JP)
IKEDA SHUN-ICHI (JP)
TAKASHIMA MASANOBU (JP)
ASANUMA NAOKI (JP)
INABA TADASHI (JP)
TAKEUCHI HIROSHI (JP)
KAWAMOTO HIROSHI (JP)
TSUKADA YOSHIHISA (JP)
SATOMURA MASATO (JP)
KITAGUCHI HIROSHI (JP)
TAKAHASHI TAKESHI (JP)
OKADA YUKO (JP)
MIZUKAMI TAMIO (JP)
TAMAOKI TATSUYA (JP)
IKEDA SHUN-ICHI (JP)
TAKASHIMA MASANOBU (JP)
ASANUMA NAOKI (JP)
INABA TADASHI (JP)
TAKEUCHI HIROSHI (JP)
KAWAMOTO HIROSHI (JP)
TSUKADA YOSHIHISA (JP)
SATOMURA MASATO (JP)
KITAGUCHI HIROSHI (JP)
Application Number:
PCT/JP1998/002242
Publication Date:
November 26, 1998
Filing Date:
May 21, 1998
Export Citation:
Assignee:
KYOWA HAKKO KOGYO KK (JP)
FUJI PHOTO FILM CO LTD (JP)
YONETANI YOSHIYUKI (JP)
TAKAHASHI TAKESHI (JP)
OKADA YUKO (JP)
MIZUKAMI TAMIO (JP)
TAMAOKI TATSUYA (JP)
IKEDA SHUN ICHI (JP)
TAKASHIMA MASANOBU (JP)
ASANUMA NAOKI (JP)
INABA TADASHI (JP)
TAKEUCHI HIROSHI (JP)
KAWAMOTO HIROSHI (JP)
TSUKADA YOSHIHISA (JP)
SATOMURA MASATO (JP)
KITAGUCHI HIROSHI (JP)
FUJI PHOTO FILM CO LTD (JP)
YONETANI YOSHIYUKI (JP)
TAKAHASHI TAKESHI (JP)
OKADA YUKO (JP)
MIZUKAMI TAMIO (JP)
TAMAOKI TATSUYA (JP)
IKEDA SHUN ICHI (JP)
TAKASHIMA MASANOBU (JP)
ASANUMA NAOKI (JP)
INABA TADASHI (JP)
TAKEUCHI HIROSHI (JP)
KAWAMOTO HIROSHI (JP)
TSUKADA YOSHIHISA (JP)
SATOMURA MASATO (JP)
KITAGUCHI HIROSHI (JP)
International Classes:
A61P35/00; C07C323/16; C07C323/25; C07C323/40; C07D207/08; C07D211/58; C07D211/60; C07D213/32; C07D215/06; C07D233/54; C07D233/61; C07D239/42; C07D239/58; C07D251/38; C07D277/44; C07D277/56; C07D309/38; C07D317/22; C07D317/28; C07D319/06; C07H5/06; C07H15/18; (IPC1-7): A61K31/10; A61K31/11; A61K31/12; A61K31/135; A61K31/155; A61K31/165; A61K31/18; A61K31/19; A61K31/215; A61K31/335; A61K31/34; A61K31/35; A61K31/40; A61K31/44; A61K31/445; A61K31/47; A61K31/495; A61K31/505; A61K31/70; C07D207/08; C07D207/408; C07D211/22; C07D213/32; C07D215/08; C07D233/61; C07D239/10; C07D239/58; C07D241/18; C07D251/38; C07D277/44; C07D295/12; C07D295/18; C07D295/22; C07D307/66; C07D309/04; C07D309/08; C07D309/30; C07D309/38; C07D317/22; C07D317/28; C07D319/06; C07D333/20; C07D521/00; C07H15/18
Domestic Patent References:
| WO1998003458A1 | 1998-01-29 | |||
| WO1996004275A1 | 1996-02-15 |
Foreign References:
| JPH03182393A | 1991-08-08 | |||
| US4612393A | 1986-09-16 | |||
| DE3541234A1 | 1986-05-28 | |||
| EP0140297A2 | 1985-05-08 | |||
| EP0119160A1 | 1984-09-19 | |||
| CA1157774A | 1983-11-29 | |||
| US4282242A | 1981-08-04 | |||
| FR1507899A | 1967-12-29 |
Other References:
JUN CHAO CAI, ET AL.: "SYNTHESIS AND ANTITUMOR PROPERTIES OF N1-ACYLOXYMETHYL DERIVATIVES OF BIS(2,6-DIOXOPIPERAZINES)", CHEMICAL AND PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOCIETY OF JAPAN, JP, vol. 37, no. 11, 1 January 1989 (1989-01-01), JP, pages 2976 - 2983, XP002917464, ISSN: 0009-2363
NOBURU MOTOHASHI: "TEST FOR ANTITUMOR ACTIVITIES OF PHENOTHIAZINES AND PHENOXAZINES", YAKUGAKU ZASSHI = JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, PHARMACEUTICAL SOCIETY OF JAPAN, JP, vol. 103, no. 03, 1 January 1983 (1983-01-01), JP, pages 364 - 371, XP002917465, ISSN: 0031-6903
KRICHELDORF H R, JAHNKE P: "NEW POLYMER SYNTHESES 55. AROMATIC POLY(ETHER-SULFIDE)S OF PYRIDINEAND PYRIDAZINE", POLYMER BULLETIN., SPRINGER, HEIDELBERG., DE, vol. 28, 1 January 1992 (1992-01-01), DE, pages 411 - 418, XP002917466, ISSN: 0170-0839, DOI: 10.1007/BF00297333
See also references of EP 0990439A4
NOBURU MOTOHASHI: "TEST FOR ANTITUMOR ACTIVITIES OF PHENOTHIAZINES AND PHENOXAZINES", YAKUGAKU ZASSHI = JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, PHARMACEUTICAL SOCIETY OF JAPAN, JP, vol. 103, no. 03, 1 January 1983 (1983-01-01), JP, pages 364 - 371, XP002917465, ISSN: 0031-6903
KRICHELDORF H R, JAHNKE P: "NEW POLYMER SYNTHESES 55. AROMATIC POLY(ETHER-SULFIDE)S OF PYRIDINEAND PYRIDAZINE", POLYMER BULLETIN., SPRINGER, HEIDELBERG., DE, vol. 28, 1 January 1992 (1992-01-01), DE, pages 411 - 418, XP002917466, ISSN: 0170-0839, DOI: 10.1007/BF00297333
See also references of EP 0990439A4
Attorney, Agent or Firm:
Imamura, Masazumi . (5th floor 5-5, Kyobashi 1-chom, Chuo-ku Tokyo, JP)
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