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Title:
BISINDOLYLMALEIMIDE DERIVATIVE AND PREPARATION METHOD AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/000224
Kind Code:
A1
Abstract:
Provided are a bisindolylmaleimide derivative and a preparation method and use thereof. The bisindolylmaleimide derivative has good therapeutic effect on tumors, especially on some drug-resistant tumors, and thus precise treatment of these drug-resistant tumors can be achieved. As another embodiment, the bisindolylmaleimide derivative has good α-glucosidase inhibitory effect and can be used to prevent or treat diabetes.

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Inventors:
ZHU WEIMING (CN)
MA HONGGUANG (CN)
WANG LIPING (CN)
XU ZHIHONG (CN)
ZHANG YAPENG (CN)
WANG YI (CN)
LIU PEIPEI (CN)
HAO JIEJIE (CN)
Application Number:
PCT/CN2017/090349
Publication Date:
January 03, 2019
Filing Date:
June 27, 2017
Export Citation:
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Assignee:
OCEAN UNIV CHINA (CN)
THE KEY LABORATORY OF CHEMISTRY FOR NATURAL PRODUCTS OF GUIZHOU PROVINCE AND CHINESE ACAD OF SCIENCE (CN)
International Classes:
C07D403/14; C07D487/14; C07D498/22; A61K31/404; A61K31/407; A61P3/10; A61P35/00
Domestic Patent References:
WO1995017182A11995-06-29
WO1998004553A11998-02-05
WO1997041127A11997-11-06
WO2007147613A22007-12-27
WO1999047518A11999-09-23
WO1996030048A11996-10-03
WO2004018495A12004-03-04
Foreign References:
CN106146475A2016-11-23
CN106083830A2016-11-09
CN101812097A2010-08-25
CN104398508A2015-03-11
Other References:
CONCHA SANCHEZ MARTINEZ ET AL.: "Studies on Cyclin-Dependent Kinase Inhibitors: Indolo-[2, 3-a]pyrrolo[3, 4-c]carbazoles versus Bis-indolylmaleimides", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 13, no. 21, 3 November 2003 (2003-11-03), pages 3841 - 384, XP008036555, ISSN: 0968-0896
Attorney, Agent or Firm:
BEIJING TANLULAI PATENT AGENT LTD (CN)
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