Title:
BISPECIFIC ANTIBODY AND ANTIBODY CONJUGATE FOR TUMOUR THERAPY AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/219974
Kind Code:
A1
Abstract:
Provided in the present invention is a bispecific antibody comprising an antibody fragment combating MUC1VHH and an antibody fragment combating CD16VHH. The antibody fragment used in the present invention is a variable region sequence derived from a heavy chain antibody of a camel and has a high binding affinity to the antigen. Antibody fragments recognizing MUC1 and CD16 are constructed in the same antibody molecule by the invention, so that the antibody molecule can specifically bind to MUC1 and CD16 molecules to promote the killing effect of NK cells on MUC1-positive expression cells and has an inhibiting effect on the growth of MUC1-positive tumours. Also provided is a conjugate of the bispecific antibodies, a related pharmaceutical composition and use.
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Inventors:
YU HAOYANG (CN)
WANG ZHONG (CN)
LI ZHENGCHENG (CN)
WANG ZHONG (CN)
LI ZHENGCHENG (CN)
Application Number:
PCT/CN2017/089307
Publication Date:
December 28, 2017
Filing Date:
June 21, 2017
Export Citation:
Assignee:
BENHEALTH BIOPHARMACEUTIC (SHENZHEN) CO LTD (CN)
International Classes:
C07K16/46; A61K39/395; A61P35/00; C07K16/28; C07K17/08; C12N15/13; C12N15/85
Foreign References:
| CN104379601A | 2015-02-25 | |||
| CN104829730A | 2015-08-12 | |||
| CN105431378A | 2016-03-23 | |||
| CN104800838A | 2015-07-29 |
Other References:
HAMERS -CASTERMAN, NATURE, vol. 363, 1993, pages 446 - 448
KABAT, E. ET AL.: "Sequences of Proteins of Immunological Interest", USDEPARTMENT OF HEALTH AND HUMAN SERVICES, 1983
CHOTHIA; LESK, J. MOI. BIOL., vol. 196, 1987, pages 901 - 917
KABAT ET AL.: "Sequences of Proteins of Immunological Interest", 1983, U.S. DEPT. OF HEALTH AND HUMAN SERVICES
CHOTHIA ET AL., J. MOL. BIOL., 1987, pages 901 - 917
KABAT ET AL.: "Sequence of Proteins of Immunological Interest", 1983, U.S. DEPT. OF HEALTH AND HUMAN SERVICES
See also references of EP 3502142A4
KABAT, E. ET AL.: "Sequences of Proteins of Immunological Interest", USDEPARTMENT OF HEALTH AND HUMAN SERVICES, 1983
CHOTHIA; LESK, J. MOI. BIOL., vol. 196, 1987, pages 901 - 917
KABAT ET AL.: "Sequences of Proteins of Immunological Interest", 1983, U.S. DEPT. OF HEALTH AND HUMAN SERVICES
CHOTHIA ET AL., J. MOL. BIOL., 1987, pages 901 - 917
KABAT ET AL.: "Sequence of Proteins of Immunological Interest", 1983, U.S. DEPT. OF HEALTH AND HUMAN SERVICES
See also references of EP 3502142A4
Attorney, Agent or Firm:
SHENZHEN ARK INTELLECTUAL PROPERTY AGENT LLP (CN)
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