Title:
BISPECIFIC ANTIBODY SIMULTANEOUSLY BINDING TO INTERLEUKIN-4 RECEPTOR ALPHA SUBUNIT AND INTERLEUKIN-5 RECEPTOR ALPHA SUBUNIT, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/055299
Kind Code:
A1
Abstract:
The present invention relates to: an IL-4Rα×IL-5Rα bispecific antibody that simultaneously binds to interleukin (IL)-4 receptor α (IL-4Rα, CD124) and IL-5 receptor α (IL-5Rα, CD125); a multispecific antibody including the bispecific antibody; a nucleic acid encoding same; a vector including the nucleic acid; cells transformed by the vector; a method for producing the bispecific antibody; and a therapeutic use thereof, for example, a composition for preventing or treating allergic diseases, inflammatory diseases, and eosinophilic diseases associated with IL-4, IL-13 and/or IL-5.
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Inventors:
KIM YONG SUNG (KR)
PARK HAE-SIM (KR)
KIM JUNG EUN (KR)
JENG KEUNOK (KR)
LEE DONG-HYUN (KR)
PARK HAE-SIM (KR)
KIM JUNG EUN (KR)
JENG KEUNOK (KR)
LEE DONG-HYUN (KR)
Application Number:
PCT/KR2021/012344
Publication Date:
March 17, 2022
Filing Date:
September 10, 2021
Export Citation:
Assignee:
UNIV AJOU IND ACADEMIC COOP FOUND (KR)
International Classes:
C07K16/28; A61K39/00; A61P29/00; A61P37/08
Domestic Patent References:
| WO2019158728A1 | 2019-08-22 | |||
| WO2009070642A1 | 2009-06-04 |
Foreign References:
| KR20150139905A | 2015-12-14 | |||
| KR20200054095A | 2020-05-19 | |||
| US7605237B2 | 2009-10-20 | |||
| KR101474227B1 | 2014-12-18 | |||
| US6018032A | 2000-01-25 | |||
| KR100259828B1 | 2000-06-15 | |||
| KR101522954B1 | 2015-05-27 |
Other References:
GODAR MARIE; DESWARTE KIM; VERGOTE KARL; SAUNDERS MICHAEL; DE HAARD HANS; HAMMAD HAMIDA; BLANCHETOT CHRISTOPHE; LAMBRECHT BART N.: "A bispecific antibody strategy to target multiple type 2 cytokines in asthma", JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, ELSEVIER, AMSTERDAM, NL, vol. 142, no. 4, 8 June 2018 (2018-06-08), AMSTERDAM, NL , pages 1185, XP085496777, ISSN: 0091-6749, DOI: 10.1016/j.jaci.2018.06.002
KIM, J.-E.: "Engineering of Bispecific Antibodies Simultaneously Targeting Human Interleukin 4 Receptor Alpha (IL-4Rα) and Interleukin 5 Receptor Alpha (IL-5Rα) for Treatment of Severe Eosinophilic Asthma", THESIS, 1 February 2021 (2021-02-01), Korea, pages 1 - 137, XP009535485
KABAT ET AL.: "Sequences of Proteins of Immunological Interest", 1991, PUBLIC HEALTH SERVICE, NATIONAL INSTITUTES OF HEALTH
KIM, J.-E.: "Engineering of Bispecific Antibodies Simultaneously Targeting Human Interleukin 4 Receptor Alpha (IL-4Rα) and Interleukin 5 Receptor Alpha (IL-5Rα) for Treatment of Severe Eosinophilic Asthma", THESIS, 1 February 2021 (2021-02-01), Korea, pages 1 - 137, XP009535485
KABAT ET AL.: "Sequences of Proteins of Immunological Interest", 1991, PUBLIC HEALTH SERVICE, NATIONAL INSTITUTES OF HEALTH
Attorney, Agent or Firm:
LEE, Cheo Young et al. (KR)
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