Title:
BISPECIFIC ANTIBODY THAT BINDS TO CD3
Document Type and Number:
WIPO Patent Application WO/2021/162098
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a bispecific antibody that binds to CD3, or a fragment of the bispecific antibody. The present invention pertains to: a bispecific antibody that binds to CD3, or a fragment of the bispecific antibody; DNA encoding the bispecific antibody or the bispecific antibody fragment; a vector including the DNA; a hybridoma and a transformant strain producing the bispecific antibody or the bispecific antibody fragment; a method for producing the bispecific antibody or the bispecific antibody fragment; a therapeutic and diagnostic agent containing the bispecific antibody or the bispecific antibody fragment; a therapeutic and diagnostic method using the bispecific antibody or the bispecific antibody fragment; and a detection or assay reagent containing the bispecific antibody or the bispecific antibody fragment.
Inventors:
NIWA RINPEI (JP)
OGAWA SHINYA (JP)
WAJIMA MAMI (JP)
KUBOTA TSUGUO (JP)
OGAWA SHINYA (JP)
WAJIMA MAMI (JP)
KUBOTA TSUGUO (JP)
Application Number:
PCT/JP2021/005276
Publication Date:
August 19, 2021
Filing Date:
February 12, 2021
Export Citation:
Assignee:
KYOWA KIRIN CO LTD (JP)
International Classes:
C12N15/13; A61K39/395; A61P35/00; C07K16/18; C07K16/28; C07K16/46; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/63; C12P21/08; G01N33/574
Domestic Patent References:
| WO2018237364A1 | 2018-12-27 | |||
| WO2019005637A2 | 2019-01-03 | |||
| WO2005035586A1 | 2005-04-21 | |||
| WO2002031140A1 | 2002-04-18 | |||
| WO2000061739A1 | 2000-10-19 | |||
| WO2000042072A2 | 2000-07-20 | |||
| WO1997010354A1 | 1997-03-20 | |||
| WO1994023021A1 | 1994-10-13 | |||
| WO2006033386A1 | 2006-03-30 | |||
| WO2003033538A1 | 2003-04-24 | |||
| WO2010143698A1 | 2010-12-16 | |||
| WO2002031140A1 | 2002-04-18 | |||
| WO2014054804A1 | 2014-04-10 | |||
| WO2016071004A1 | 2016-05-12 | |||
| WO2019017401A1 | 2019-01-24 | |||
| WO2017210443A1 | 2017-12-07 |
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| JP2017529067A | 2017-10-05 | |||
| KR20120129834A | 2012-11-28 | |||
| JP2019509055A | 2019-04-04 | |||
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| US4939094A | 1990-07-03 | |||
| US5160735A | 1992-11-03 | |||
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| JPS63299A | 1988-01-05 | |||
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NUCLEIC ACIDS RESEARCH, vol. 13, 1985, pages 4431
PROCEEDING OF THE NATIONAL ACADEMY OF SCIENCES IN USA, vol. 82, 1985, pages 488
"GenBank Accession", Database accession no. NM_001283615.1
"Core Techniques, A Practical Approach", 1995, OXFORD UNIVERSITY
J. MOL. BIOL., vol. 215, 1990, pages 403
NUCLEIC ACIDS RESEARCH, vol. 25, 1997, pages 3389
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"Antibodies - A Laboratory Manual", 1988, COLD SPRING HARBOR LABORATORY
CURRENT OPINION IN BIOTECHNOLOGY, vol. 20, 2009, pages 685 - 691
NATURE BIOTECHNOLOGY, vol. 16, 1998, pages 677 - 681
PROC. NATL. ACAD. SCI., USA, vol. 79, 1982, pages 6409
PROC. NATL. ACAD. SCI USA, vol. 82, 1985, pages 488
BECK ET AL., ANALYTICAL CHEMISTRY, vol. 85, 2013, pages 715 - 736
NAT REV DRUG DISCOV, vol. 18, 2019, pages 585 - 608
NAT REV DRUG DISCOV., vol. 18, 2019, pages 585 - 608
ANNU. REV. IMMUNOL., vol. 9, 1991, pages 457 - 492
CANCER IMMUNOL. IMMUNOTHER., vol. 36, 1993, pages 373
AGRICULTURAL BIOLOGICAL CHEMISTRY, vol. 48, 1984, pages 669
PROC. NATL. ACAD. SCI. USA, vol. 82, 1985, pages 4306
J. BACTERIOL., vol. 172, 1990, pages 2392
PROC. NATL. ACAD. SCI. USA, vol. 69, 1972, pages 2110
GENE, vol. 17, 1982, pages 107
MOLECULAR & GENERAL GENETICS, vol. 168, 1979, pages 111
CYTOTECHNOLOGY, vol. 3, 1990, pages 133
J. BIOCHEMISTRY, vol. 101, 1987, pages 1307
PROC. NATL. ACAD. SCI. USA, vol. 84, 1987, pages 7413
PAULSON ET AL., J. BIOL. CHEM., vol. 264, 1989, pages 17619
LOWE ET AL., PROC. NATL. ACAD. SCI., USA, vol. 86, 1989, pages 8227
GENES DEVELOP., vol. 4, 1998, pages 1288
TOMIZUKA ET AL., PROC NATL ACAD SCI USA, vol. 97, 2000, pages 722
EUROPEAN J. IMMUNOLOGY, vol. 6, 1976, pages 511
NATURE, vol. 276, 1978, pages 269
J. IMMUNOLOGY, vol. 123, 1979, pages 1548
NATURE, vol. 256, 1975, pages 495
P. J. DELVES.: "ANTIBODY PRODUCTION ESSENTIAL TECHNIQUES.", 1997, WILEY
ISHIDALONBERG, IBC'S 11 TH ANTIBODY ENGINEERING, 2000
CYTOTECHNOL., vol. 13, 1993, pages 79
METHODS IN ENZYMOL., vol. 154, no. 3, 1987
STRATEGIES, vol. 5, 1992, pages 81
NUCLEIC ACIDS RESEARCH, vol. 17, 1989, pages 9494
DNA CLONING: A PRACTICAL APPROACH, 1985, pages 49
MOL. CELL. BIOL., vol. 3, 1983, pages 280
GENETICS, vol. 39, 1954, pages 440
SCIENCE, vol. 222, 1983, pages 778
J. MOL. BIOL., vol. 166, 1983, pages 1
J. MOL. BIOL., vol. 16, 1966, pages 118
J. MOL. BIOL., vol. 112, 1977, pages 5463
CYTOTECHNOL, vol. 4, 1990, pages 173
J. BIOCHEM., vol. 101, 1987, pages 1307
GENE, vol. 27, 1984, pages 223
PROC. NATL. ACAD. SCI. USA, vol. 78, 1981, pages 1527
BIOCHEM. BIOPHYS. RES. COMMUN., vol. 149, 1987, pages 960
CELL, vol. 41, 1985, pages 479
CELL, vol. 33, 1983, pages 717
J. IMMUNOL. METHODS, vol. 167, 1994, pages 271
HYBRIDOMA, vol. 17, 1998, pages 559
BIO/TECHNOLOGY, vol. 9, 1991, pages 266
PROTEIN ENGINEERING, vol. 7, 1994, pages 1501
J. EXP. MED., vol. 174, 1991, pages 319 - 326
PROC. NATL. ACAD. SCI. USA, vol. 77, 1980, pages 4216
SOMATIC CELL AND MOLECULAR GENETICS, vol. 12, 1986, pages 55
NATURE, vol. 227, 1970, pages 680
"Fluorescent Antibody Method", 1983, SOFT SCIENCE, INC.
"Proc. Natl. Acad. Sci. U.S.A.", vol. 89, 1992, pages: 4285
SOMATIC CELL MOL GENET, vol. 12, 1986, pages 555
CLIN CANCER RES., vol. 13, 2007, pages 1875 - 1882
CLIN CANCER RES., vol. 11, no. 8, 2005, pages 3126 - 3135
CHEN X ET AL., ADV. DRUG DELIV. REV., vol. 65, 2013, pages 1357 - 1369
EMBO J., vol. 4, no. 2, 1985, pages 337 - 344
J. IMMUNOL., vol. 137, no. 4, 1986, pages 1097 - 100
J. IMMUNOL., vol. 147, no. 9, 1991, pages 3047 - 52
ISHIDA, I. ET AL., CLONING & STEM CELLS, vol. 4, 2002, pages 91 - 102
ISAMU ISHIDA, EXPERIMENTAL MEDICINE, vol. 20, no. 6, 2002, pages 846 - 851
EUROPEAN JOURNAL OF IMMUNOLOGY, vol. 6, 1976, pages 511
See also references of EP 4105330A4
CARTRON GDACHEUX LSALLES G ET AL., BLOOD, vol. 99, 2002, pages 754 - 758
WENG WKLEVY R, J CLIN ONCOL, vol. 21, 2003, pages 3940 - 3947
SHINKAWA TNAKAMURA KYAMANE N ET AL., J BIOL CHEM., vol. 278, 2003, pages 3466 - 3473
BECK AREICHERT JM, MABS, vol. 4, 2012, pages 419 - 425
GAGEZ AL, CARTRON G. CURR OPIN ONCOL, vol. 26, 2014, pages 484 - 491
CARTER PJLAZAR GA, NAT REV DRUG DISC, vol. 17, 2018, pages 197 - 223
BOKEMEYER C, EXPERT OPIN BIOL THER, vol. 10, 2010, pages 1259 - 1269
NAGORSEN DKUFER PBAEUERLE PABARGOU R, PHARMACOL THER, vol. 136, 2012, pages 334 - 342
BACAC MFAUTI TSAM J ET AL., CLIN CANCER RES., vol. 22, no. 13, 2016, pages 3286 - 4427
BERGMAN IBASSE PBARMADA MGRIFFIN JCHEUNG N, CANCER IMMUNOL IMMUNOTHER, vol. 49, 2010, pages 259 - 266
CEUPPENS JLBLOEMMEN FJVAN WAUWE JP, J IMMUNOL., vol. 135, 1985, pages 3882 - 3886
BORLAK JLANGER FSPANEL R.SCHONDORFER G.DITTRICH C, ONCOTARGET, vol. 7, 2016, pages 28059 - 28074
BACAC MKLEIN C., UMANA P ONCOIMMUNOLOGY, vol. 5, no. 8, 2016, pages e1203498
AGRIC. BIOL. CHEM., vol. 53, 1989, pages 277
NATURE, vol. 329, 1987, pages 840
NUCLEIC ACIDS RESEARCH, vol. 10, 1982, pages 6487
GENE, vol. 38, 1985, pages 275
NUCLEIC ACIDS RESEARCH, vol. 13, 1985, pages 4431
PROCEEDING OF THE NATIONAL ACADEMY OF SCIENCES IN USA, vol. 82, 1985, pages 488
"GenBank Accession", Database accession no. NM_001283615.1
"Core Techniques, A Practical Approach", 1995, OXFORD UNIVERSITY
J. MOL. BIOL., vol. 215, 1990, pages 403
NUCLEIC ACIDS RESEARCH, vol. 25, 1997, pages 3389
GENOME RESEARCH, vol. 7, 1997, pages 649, Retrieved from the Internet
NAT. BIOTECHNOL., vol. 14, 1996, pages 1239 - 45
"Antibodies - A Laboratory Manual", 1988, COLD SPRING HARBOR LABORATORY
CURRENT OPINION IN BIOTECHNOLOGY, vol. 20, 2009, pages 685 - 691
NATURE BIOTECHNOLOGY, vol. 16, 1998, pages 677 - 681
PROC. NATL. ACAD. SCI., USA, vol. 79, 1982, pages 6409
PROC. NATL. ACAD. SCI USA, vol. 82, 1985, pages 488
BECK ET AL., ANALYTICAL CHEMISTRY, vol. 85, 2013, pages 715 - 736
NAT REV DRUG DISCOV, vol. 18, 2019, pages 585 - 608
NAT REV DRUG DISCOV., vol. 18, 2019, pages 585 - 608
ANNU. REV. IMMUNOL., vol. 9, 1991, pages 457 - 492
CANCER IMMUNOL. IMMUNOTHER., vol. 36, 1993, pages 373
AGRICULTURAL BIOLOGICAL CHEMISTRY, vol. 48, 1984, pages 669
PROC. NATL. ACAD. SCI. USA, vol. 82, 1985, pages 4306
J. BACTERIOL., vol. 172, 1990, pages 2392
PROC. NATL. ACAD. SCI. USA, vol. 69, 1972, pages 2110
GENE, vol. 17, 1982, pages 107
MOLECULAR & GENERAL GENETICS, vol. 168, 1979, pages 111
CYTOTECHNOLOGY, vol. 3, 1990, pages 133
J. BIOCHEMISTRY, vol. 101, 1987, pages 1307
PROC. NATL. ACAD. SCI. USA, vol. 84, 1987, pages 7413
PAULSON ET AL., J. BIOL. CHEM., vol. 264, 1989, pages 17619
LOWE ET AL., PROC. NATL. ACAD. SCI., USA, vol. 86, 1989, pages 8227
GENES DEVELOP., vol. 4, 1998, pages 1288
TOMIZUKA ET AL., PROC NATL ACAD SCI USA, vol. 97, 2000, pages 722
EUROPEAN J. IMMUNOLOGY, vol. 6, 1976, pages 511
NATURE, vol. 276, 1978, pages 269
J. IMMUNOLOGY, vol. 123, 1979, pages 1548
NATURE, vol. 256, 1975, pages 495
P. J. DELVES.: "ANTIBODY PRODUCTION ESSENTIAL TECHNIQUES.", 1997, WILEY
ISHIDALONBERG, IBC'S 11 TH ANTIBODY ENGINEERING, 2000
CYTOTECHNOL., vol. 13, 1993, pages 79
METHODS IN ENZYMOL., vol. 154, no. 3, 1987
STRATEGIES, vol. 5, 1992, pages 81
NUCLEIC ACIDS RESEARCH, vol. 17, 1989, pages 9494
DNA CLONING: A PRACTICAL APPROACH, 1985, pages 49
MOL. CELL. BIOL., vol. 3, 1983, pages 280
GENETICS, vol. 39, 1954, pages 440
SCIENCE, vol. 222, 1983, pages 778
J. MOL. BIOL., vol. 166, 1983, pages 1
J. MOL. BIOL., vol. 16, 1966, pages 118
J. MOL. BIOL., vol. 112, 1977, pages 5463
CYTOTECHNOL, vol. 4, 1990, pages 173
J. BIOCHEM., vol. 101, 1987, pages 1307
GENE, vol. 27, 1984, pages 223
PROC. NATL. ACAD. SCI. USA, vol. 78, 1981, pages 1527
BIOCHEM. BIOPHYS. RES. COMMUN., vol. 149, 1987, pages 960
CELL, vol. 41, 1985, pages 479
CELL, vol. 33, 1983, pages 717
J. IMMUNOL. METHODS, vol. 167, 1994, pages 271
HYBRIDOMA, vol. 17, 1998, pages 559
BIO/TECHNOLOGY, vol. 9, 1991, pages 266
PROTEIN ENGINEERING, vol. 7, 1994, pages 1501
J. EXP. MED., vol. 174, 1991, pages 319 - 326
PROC. NATL. ACAD. SCI. USA, vol. 77, 1980, pages 4216
SOMATIC CELL AND MOLECULAR GENETICS, vol. 12, 1986, pages 55
NATURE, vol. 227, 1970, pages 680
"Fluorescent Antibody Method", 1983, SOFT SCIENCE, INC.
"Proc. Natl. Acad. Sci. U.S.A.", vol. 89, 1992, pages: 4285
SOMATIC CELL MOL GENET, vol. 12, 1986, pages 555
CLIN CANCER RES., vol. 13, 2007, pages 1875 - 1882
CLIN CANCER RES., vol. 11, no. 8, 2005, pages 3126 - 3135
CHEN X ET AL., ADV. DRUG DELIV. REV., vol. 65, 2013, pages 1357 - 1369
EMBO J., vol. 4, no. 2, 1985, pages 337 - 344
J. IMMUNOL., vol. 137, no. 4, 1986, pages 1097 - 100
J. IMMUNOL., vol. 147, no. 9, 1991, pages 3047 - 52
ISHIDA, I. ET AL., CLONING & STEM CELLS, vol. 4, 2002, pages 91 - 102
ISAMU ISHIDA, EXPERIMENTAL MEDICINE, vol. 20, no. 6, 2002, pages 846 - 851
EUROPEAN JOURNAL OF IMMUNOLOGY, vol. 6, 1976, pages 511
See also references of EP 4105330A4
Attorney, Agent or Firm:
Eikoh Patent Firm, P.C. (JP)
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