Title:
BISPECIFIC ANTIBODY THAT BINDS TO CD116 AND CD131
Document Type and Number:
WIPO Patent Application WO/2023/027177
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a bispecific antibody and a fragment of said bispecific antibody that have an agonist activity against GM-CSF receptors. The present invention relates to a bispecific antibody, or a fragment of said bispecific antibody, including a first antigen binding domain and a second antigen binding domain, wherein one of the first antigen binding domain and the second antigen binding domain is an antigen binding domain that binds to CD116, and the other is an antigen binding domain that binds to CD131.
Inventors:
KATO AKIFUMI (JP)
NISHIYA HARUE (JP)
NAKANO RYOSUKE (JP)
NISHIYA HARUE (JP)
NAKANO RYOSUKE (JP)
Application Number:
PCT/JP2022/032233
Publication Date:
March 02, 2023
Filing Date:
August 26, 2022
Export Citation:
Assignee:
KYOWA KIRIN CO LTD (JP)
International Classes:
C07K16/28; A61K39/395; A61P43/00; C07K16/46; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/62; C12N15/63; C12P21/08
Domestic Patent References:
| WO2017030156A1 | 2017-02-23 | |||
| WO2005035586A1 | 2005-04-21 | |||
| WO2002031140A1 | 2002-04-18 | |||
| WO2000061739A1 | 2000-10-19 | |||
| WO2000042072A2 | 2000-07-20 | |||
| WO1997010354A1 | 1997-03-20 | |||
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| WO2003033538A1 | 2003-04-24 | |||
| WO2010143698A1 | 2010-12-16 | |||
| WO2002031140A1 | 2002-04-18 | |||
| WO2006031653A2 | 2006-03-23 |
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HEINZELMAN PETE, CARLSON SHARON J., COX GEORGE N.: "Cytokine refacing effect reduces granulocyte macrophage colony-stimulating factor susceptibility to antibody neutralization", PROTEIN ENGINEERING, DESIGN AND SELECTION, OXFORD JOURNAL, LONDON, GB, vol. 28, no. 10, 1 October 2015 (2015-10-01), GB , pages 461 - 466, XP093038442, ISSN: 1741-0126, DOI: 10.1093/protein/gzv019
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PROC. NATL. ACAD. SCI. USA, vol. 91, 1994, pages 5592 - 5596
CELL, vol. 134, 2008, pages 496 - 507
CYTOKINE, vol. 74, 2015, pages 247 - 258
J. EXP. MED., vol. 190, 1999, pages 875 - 880
BLOOD, vol. 113, 2009, pages 2547 - 2556
GASTROENTEROLOGY, vol. 136, 2009, pages 1261 - 1271
INFLAMM. BOWEL DIS., vol. 19, 2013, pages 1671 - 1680
EUR J HAEMATOL., vol. 55, 1995, pages 348 - 356
N ENGL J MED., vol. 381, 2019, pages 923 - 932
N ENGL J MED., vol. 352, 2005, pages 2193 - 2201
PROTEIN ENG DES SEL., vol. 28, 2015, pages 461 - 466
BLOOD, vol. 103, 2004, pages 1089 - 1098
EBIOMEDICINE, vol. 30, 2015, pages 730 - 743
"GenBank", Database accession no. XP 01 5312724_1
AGRIC. BIOL. CHEM., vol. 53, 1989, pages 277
NATURE, vol. 329, 1987, pages 840
NUCLEIC ACIDS RESEARCH, vol. 10, 1982, pages 6487
PROC. NATL. ACAD. SCI. USA, vol. 79, 1982, pages 6409
GENE, vol. 38, 1985, pages 275
NUCLEIC ACIDS RESEARCH, vol. 13, 1985, pages 4431
PROCEEDING OF THE NATIONAL ACADEMY OF SCIENCES IN USA, vol. 82, 1985, pages 488
BIOCHEMISTRY, vol. 34, 1995, pages 14649
J. MOL. BIOL., vol. 215, 1990, pages 403
NUCLEIC ACIDS RESEARCH, vol. 25, 1997, pages 3389
GENOME RESEARCH, vol. 7, 1997, pages 649
CYTOKINE GROWTH FACTOR REV., vol. 12, 2001, pages 19
"UniProt", Database accession no. P32927
ANNU. REV. IMMUNOL., vol. 9, 1991, pages 457 - 492
CLINICAL ONCOLOGY, CANCER AND CHEMOTHERAPY, 1996
"Antibodies-A Laboratory Manual", 1988, COLD SPRING HARBOR LABORATORY
PROC. NATL. ACAD. SCI ., USA, vol. 79, 1982, pages 6409
PROC. NATL. ACAD. SCI USA, vol. 82, 1985, pages 488
BECK ET AL., ANALYTICAL CHEMISTRY, vol. 85, 2013, pages 715 - 736
KOLB ET AL., ANGEW CHEM INT ED ENGL., vol. 40, 2001, pages 2004 - 21
CANCER IMMUNOL. IMMUNOTHER, vol. 36, 1993, pages 373
NAT. REV. IMMUNOL., vol. 7, 2007, pages 715
J. IMMUNOL., vol. 176, 2006, pages 346
INT. IMMUNOL., vol. 13, 2001, pages 993
J. BIOL. CHEM., vol. 276, 2001, pages 6591
J. IMMUNOL., vol. 169, 2002, pages 5171
CHIJIN SHOKAN, INTRODUCTION TO ANTIBODY ENGINEERING, 1994
GENE, vol. 17, 1982, pages 107
CANCER IMMUNOL. IMMUNOTHER., vol. 36, 1993, pages 373
AGRICULTURAL BIOLOGICAL CHEMISTRY, vol. 48, 1984, pages 669
PROC. NATL. ACAD. SCI. USA, vol. 82, 1985, pages 4306
J. BACTERIOL., vol. 172, 1990, pages 2392
PROC. NATL. ACAD. SCI. USA, vol. 69, 1972, pages 2110
MOLECULAR & GENERAL GENETICS, vol. 168, 1979, pages 111
CYTOTECHNOLOGY, vol. 3, 1990, pages 133
J. BIOCHEMISTRY, vol. 101, 1987, pages 1307
PROC. NATL. ACAD. SCI. USA, vol. 84, 1987, pages 7413
THE JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, vol. 199, 1967, pages 519
SCIENCE, vol. 122, 1952, pages 501
VIROLOGY, vol. 8, 1959, pages 396
PROC. SOC. EXP. BIOL. MED., vol. 73, 1950, pages 1
PAULSON ET AL., J. BIOL. CHEM., vol. 264, 1989, pages 17619
ROWE ET AL., PROC. NATL. ACAD. SCI., USA, vol. 86, 1989, pages 8227
GENES DEVELOP., vol. 4, 1990, pages 1288
TOMIZUKA. ET AL., PROC NATL ACAD SCI USA., vol. 97, 2000, pages 722
CURRENT TOPICS IN MICROBIOLOGY AND IMMUNOLOGY, vol. 18, 1978, pages 1
EUROPEAN J. IMMUNOLOGY, vol. 6, 1976, pages 511
NATURE, vol. 276, 1978, pages 269
J. IMMUNOLOGY, vol. 123, 1979, pages 1548
NATURE, vol. 256, 1975, pages 495
EMMANUELLE LAFFY, HUMAN ANTIBODIES, vol. 14, 2005, pages 33 - 55
P. J. DELVES.: "ANTIBODY PRODUCTION ESSENTIAL TECHNIQUES", 1997, WILEY
ISHIDALONBERG, IBC'S 11TH ANTIBODY ENGINEERING, 2000
CYTOTECHNOL., vol. 13, 1993, pages 79
METHODS IN ENZYMOL, vol. 154, 1987, pages 3
STRATEGIES, vol. 5, 1992, pages 81
NUCLEIC ACIDS RESEARCH, vol. 17, 1989, pages 9494
DNA CLONING: A PRACTICAL APPROACH, vol. I, 1985, pages 49
MOL. CELL. BIOL., vol. 3, 1983, pages 280
GENETICS, vol. 39, 1954, pages 440
SCIENCE, vol. 222, 1983, pages 778
J. MOL. BIOL., vol. 166, 1983, pages 1
J. MOL. BIOL., vol. 16, 1966, pages 118
PROC. NATL. ACAD. SCI. USA, vol. 74, 1977, pages 5463
BIO/TECHNOLOGY, vol. 9, 1991, pages 266
CYTOTECHNOL., vol. 4, 1990, pages 173
J. BIOCHEM., vol. 101, 1987, pages 1307
GENE, vol. 27, 1984, pages 223
PROC. NATL. ACAD. SCI. USA, vol. 78, 1981, pages 1527
BIOCHEM. BIOPHYS. RES. COMMUN., vol. 149, 1987, pages 960
CELL, vol. 41, 1985, pages 479
CELL, vol. 33, 1983, pages 717
J. IMMUNOL. METHODS, vol. 167, 1994, pages 271
HYBRIDOMA, vol. 17, 1998, pages 559
J. MOL. BIOL., vol. 112, 1977, pages 535
PROTEIN ENGINEERING, vol. 7, 1994, pages 1501
"Methods in Nucleic Acids Res.", 1991, CRC PRESS
"Monoclonal Antibodies-Principles and practice", 1996, ACADEMIC PRESS
PROC. NATL. ACAD. SCI. USA, vol. 77, 1980, pages 4216
SOMATIC CELL AND MOLECULAR GENETICS, vol. 12, 1986, pages 55
NATURE, vol. 227, 1970, pages 680
"Monoclonal Antibody Experiment Manual", 1987, KODANSHA SCIENTIFIC
"Fluorescent Antibody Method", 1983, SOFT SCIENCE CO., LTD.
"Bioluminescence, Chemiluminescence Clinical Examination", vol. 42, 1998, HIROKAWA SHOTEN
"Genbank", Database accession no. YP 01 5312724_1
ISHIDA, I. ET AL., CLONING & STEM CELLS, vol. 4, 2002, pages 91 - 102
ISHIDA ISAO, XPERIMENTAL MEDICINE, vol. 20, no. 6, 2002, pages 846 - 851
EUROPEAN JOURNAL OF IMMUNOLOGY, vol. 6, 1976, pages 511
MABS, vol. 7, 2015, pages 377
PROTEIN ENGINEERING, DESIGN & SELECTION, vol. 29, 2016, pages 457
INT IMMUNOL., vol. 18, 2006, pages 1759
Attorney, Agent or Firm:
Eikoh Patent Firm, P.C. (JP)
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