Title:
BISPECIFIC ANTIBODY AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/111559
Kind Code:
A1
Abstract:
Provided in the present application is a multispecific antibody, which includes a first targeting moiety capable of specifically binding to the TIGIT protein and a second targeting moiety capable of binding to a tumor-associated antigen, and the multispecific antibody can be used to treat a tumor. Further provided in the present application is the use of the multispecific antibody as a drug.
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Inventors:
ZHU XIANGYANG (CN)
CUI XIAOPEI (CN)
XU JINGEN (CN)
YU HAIJIA (CN)
CUI XIAOPEI (CN)
XU JINGEN (CN)
YU HAIJIA (CN)
Application Number:
PCT/CN2021/133003
Publication Date:
June 02, 2022
Filing Date:
November 25, 2021
Export Citation:
Assignee:
SHANGHAI HUAOTA BIOPHARMACEUTICAL CO LTD (CN)
HUABO BIOPHARM SHANGHAI CO LTD (CN)
HUABO BIOPHARM SHANGHAI CO LTD (CN)
International Classes:
C07K16/46; A61K39/395; C12N5/00; C12N15/13; C12N15/53
Domestic Patent References:
| WO2015009856A2 | 2015-01-22 | |||
| WO2020199860A1 | 2020-10-08 |
Foreign References:
| CN110818795A | 2020-02-21 | |||
| CN112661854A | 2021-04-16 | |||
| CN109219618A | 2019-01-15 | |||
| US20190100591A1 | 2019-04-04 | |||
| CN109929037A | 2019-06-25 | |||
| US5500362A | 1996-03-19 | |||
| US5821337A | 1998-10-13 | |||
| US6737056B1 | 2004-05-18 |
Other References:
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D. J. LIPMANW. R. PEARSON: "Rapid and Sensitive Protein Similarity Searches", SCIENCE, vol. 227, 1989, pages 1435 - 1441
S. ALTSCHULW. GISHW. MILLERE. W. MYERSD. LIPMAN: "Basic Local Alignment Search Tool", J. MOL. BIOL., vol. 215, 1990, pages 403 - 410
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KOHLERMILSTEIN, NATURE, vol. 256, 1975, pages 495 - 497
AL-LAZIKANI ET AL., JMOL BIOL, vol. 273, 1997, pages 927 - 48
KABAT ET AL., ANN. NY ACAD. SCI., vol. 190, 1971, pages 382 - 391
CLYNES ET AL., PNAS, vol. 95, 1998, pages 652 - 656
SARMAY ET AL., MOLEC. IMMUNOL., vol. 29, no. 5, 1992, pages 633 - 9
W. R. PEARSOND. J. LIPMAN: "Improved Tools for Biological Sequence Comparison", PROC. NATL. ACAD. SCI., vol. 85, 1988, pages 2444 - 2448
D. J. LIPMANW. R. PEARSON: "Rapid and Sensitive Protein Similarity Searches", SCIENCE, vol. 227, 1989, pages 1435 - 1441
S. ALTSCHULW. GISHW. MILLERE. W. MYERSD. LIPMAN: "Basic Local Alignment Search Tool", J. MOL. BIOL., vol. 215, 1990, pages 403 - 410
SAMBROOK ET AL.: "Molecular Cloning: A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
AUSUBE ET AL.: "Current Protocols in Molecular Biology", 1993, WILEY-INTERSCIENCE
KOHLERMILSTEIN, NATURE, vol. 256, 1975, pages 495 - 497
Attorney, Agent or Firm:
SHANGHAI DIANSHI PARTNERS, P.C. (CN)
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