Title:
BISPECIFIC ANTIBODY WHICH BINDS TO CD40 AND EpCAM
Document Type and Number:
WIPO Patent Application WO/2019/093342
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a bispecific antibody containing an antigen-binding domain which binds to CD40 and an antigen-binding domain which binds to the Epithelial Cell Adhesion Molecule (EpCAM). This invention pertains to a bispecific antibody containing an antigen-binding domain which binds to CD40 and an antigen-binding domain which binds to EpCAM.
Inventors:
NAKAYAMA MAKOTO (JP)
TAKAHASHI NOBUAKI (JP)
MAEDA SAYAKA (JP)
NIWA RINPEI (JP)
TAKAHASHI NOBUAKI (JP)
MAEDA SAYAKA (JP)
NIWA RINPEI (JP)
Application Number:
PCT/JP2018/041250
Publication Date:
May 16, 2019
Filing Date:
November 06, 2018
Export Citation:
Assignee:
KYOWA HAKKO KIRIN CO LTD (JP)
International Classes:
C07K16/46; A61K39/395; A61K49/16; A61P35/00; C07K16/30; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/13; C12N15/61; C12P21/08; G01N33/53
Domestic Patent References:
| WO2009131239A1 | 2009-10-29 | |||
| WO2006033386A1 | 2006-03-30 | |||
| WO1999061057A2 | 1999-12-02 | |||
| WO2001077342A1 | 2001-10-18 | |||
| WO2009131239A1 | 2009-10-29 | |||
| WO2015156268A1 | 2015-10-15 | |||
| WO2017205738A1 | 2017-11-30 | |||
| WO1999061057A2 | 1999-12-02 | |||
| WO1998050431A2 | 1998-11-12 | |||
| WO2001007734A1 | 2001-02-01 | |||
| WO2002002773A2 | 2002-01-10 | |||
| WO2005035586A1 | 2005-04-21 | |||
| WO2002031140A1 | 2002-04-18 | |||
| WO2000061739A1 | 2000-10-19 | |||
| WO2000042072A2 | 2000-07-20 | |||
| WO1997010354A1 | 1997-03-20 | |||
| WO1994023021A1 | 1994-10-13 | |||
| WO2006033386A1 | 2006-03-30 | |||
| WO2003033538A1 | 2003-04-24 | |||
| WO2010143698A1 | 2010-12-16 | |||
| WO2002031140A1 | 2002-04-18 | |||
| WO2003040170A2 | 2003-05-15 | |||
| WO2003040725A2 | 2003-05-15 | |||
| WO1992022653A1 | 1992-12-23 | |||
| WO2016071004A1 | 2016-05-12 |
Foreign References:
| US20070238665A1 | 2007-10-11 | |||
| US20070071675A1 | 2007-03-29 | |||
| US20070148165A1 | 2007-06-28 | |||
| US6737056B1 | 2004-05-18 | |||
| US7297775B2 | 2007-11-20 | |||
| US7317091B2 | 2008-01-08 | |||
| JPS61178926A | 1986-08-11 | |||
| JPS5623587A | 1981-03-05 | |||
| JPH02117920A | 1990-05-02 | |||
| JPS58110600A | 1983-07-01 | |||
| JPS60221091A | 1985-11-05 | |||
| US4686191A | 1987-08-11 | |||
| US4939094A | 1990-07-03 | |||
| US5160735A | 1992-11-03 | |||
| JPH0322979A | 1991-01-31 | |||
| JPH02227075A | 1990-09-10 | |||
| JPS63299A | 1988-01-05 | |||
| JPH05336963A | 1993-12-21 | |||
| US6001358A | 1999-12-14 | |||
| US5168062A | 1992-12-01 | |||
| JPH02257891A | 1990-10-18 | |||
| JP2017215834A | 2017-12-07 |
Other References:
BRUNEKREEFT, KIM L. ET AL.: "Targeted delivery of CD 40L promotes restricted activation of antigen- presenting cells and induction of cancer cell death", MOLECULAR CANCER, vol. 13, no. 85, 2014, pages 1 - 13, XP021184828, ISSN: 1476-4598, DOI: 10.1186/1476-4598-13-85
YE, SHIMING ET AL.: "Enhancement of tumor specific immunity by activation of CD 40 through a biospecific molecule targeting CD 40 and a tumor surface antigen", JOURNAL FOR IMMUNO THERAPY OF CANCER, vol. 5, no. Suppl. 2 : 87, 7 November 2017 (2017-11-07), pages 182, XP009520353, DOI: 10.1186/s40425-017-0288-4
NUCLEIC ACIDS RESEARCH, vol. 25, 1997, pages 3389
SURESH, METHODS ENZYMOL., vol. 121, 1986, pages 210 - 228
KRANZ, J. HEMATOTHER., vol. 5, 1995, pages 403 - 408
WU, NAT. BIOTHECH., vol. 25, 2007, pages 1290 - 1297
CLARK, PNAS USA, vol. 83, 1986, pages 4494 - 4498
CHUNTHARAPAI, J. IMMUNOL., vol. 166, no. 8, 2001, pages 4891
ASHKENAZI, NAT REV CANCER, vol. 2, 2002, pages 420
KAWABE, IMMUNITY, vol. 1, 1994, pages 167 - 168
DIEHL LET., NAT MED., vol. 5, no. 7, July 1999 (1999-07-01), pages 774 - 9
BEATTY GL, EXPERT REV ANTICANCER THER., vol. 17, no. 2, February 2017 (2017-02-01), pages 175 - 186
VONDERHEIDE RH, ONCOIMMUNOLOGY, vol. 2, no. 1, 1 January 2013 (2013-01-01), pages e23033
BRIDGES, J IMMUMOL, vol. 139, 1987, pages 4242 - 4549
1541376565889_0, MOL CANCER., vol. 13, 17 April 2014 (2014-04-17), pages 85
VAN DER GUN BT, BR J CANCER, vol. 105, no. 2, 12 July 2011 (2011-07-12), pages 312 - 9
CHAUDRY MA, BR J CANCER, vol. 96, no. 7, 10 April 2007 (2007-04-10), pages 1013 - 9
MARKUS M, CANCER CELL INT., vol. 10, 2 November 2010 (2010-11-02), pages 44
LINKE R, MABS, vol. 2, no. 2, 2010, pages 129 - 136
"GenBank", Database accession no. NP _001035118
AGRIC. BIOL. CHEM., vol. 53, 1989, pages 277
NATURE, vol. 329, 1987, pages 840
NUCLEIC ACIDS RESEARCH, vol. 10, 1982, pages 6487
PROC. NATL. ACAD. SCI. USA, vol. 79, 1982, pages 6409
GENE, vol. 38, 1985, pages 275
NUCLEIC ACIDS RESEARCH, vol. 13, 1985, pages 4431
PROCEEDING OF THE NATIONAL ACADEMY OF SCIENCES IN USA, vol. 82, 1985, pages 488
"A Practical Approach", 1995, OXFORD UNIVERSITY, article "DNA Cloning 1: Core Techniques"
J. MOL. BIOL., vol. 215, 1990, pages 403
GENOME RESEARCH, vol. 7, 1997, pages 649, Retrieved from the Internet
ANNU. REV. IMMUNOL., vol. 9, 1991, pages 457 - 492
"Clinical oncology", JAPANESE JOURNAL OF CANCER AND CHEMOTHERAPY, 1996
"Antibodies - A Laboratory Manual", 1988, COLD SPRING HARBOR LABORATORY
NATURE PROTOCOLS, vol. 9, 2014, pages 2450 - 2463
PROC. NATL. ACAD. SCI., USA, vol. 79, 1982, pages 6409
PROC. NATL. ACAD. SCI USA, vol. 82, 1985, pages 488
BECK ET AL., ANALYTICAL CHEMISTRY, vol. 85, 2013, pages 715 - 736
CANCER IMMUNOL. IMMUNOTHER., vol. 36, 1993, pages 373
J. IMMUNOL. METHODS, vol. 167, 1994, pages 271
GENE, vol. 17, 1982, pages 107
CYTOTECHNOL., vol. 13, 1993, pages 79
GENE, vol. 27, 1984, pages 223
PROC. NATL. ACAD. SCI. USA, vol. 82, 1985, pages 4306
J. BACTERIOL., vol. 172, 1990, pages 2392
PROC. NATL. ACAD. SCI. USA, vol. 69, 1972, pages 2110
MOLECULAR & GENERAL GENETICS, vol. 168, 1979, pages 111
CYTOTECHNOLOGY, vol. 3, 1990, pages 133
J. BIOCHEMISTRY, vol. 101, 1987, pages 1307
PROC. NATL. ACAD. SCI. USA, vol. 84, 1987, pages 7413
THE JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, vol. 199, 1967, pages 519
SCIENCE, vol. 122, 1952, pages 501
VIROLOGY, vol. 8, 1959, pages 396
PROC. SOC. EXP. BIOL. MED., vol. 73, 1950, pages 1
PAULSON ET AL., J. BIOL. CHEM., vol. 264, 1989, pages 17619
LOWE ET AL., PROC. NATL. ACAD. SCI., USA, vol. 86, 1989, pages 8227
GENES DEVELOP., vol. 4, 1990, pages 1288
TOMIZUKA ET AL., PROC NATL ACAD SCI USA, vol. 97, 2000, pages 722
NATURE, vol. 276, 1978, pages 269
EUROPEAN J. IMMUNOLOGY, vol. 6, 1976, pages 511
J. IMMUNOLOGY, vol. 123, 1979, pages 1548
NATURE, vol. 256, 1975, pages 495
P. J. DELVES.: "ANTIBODY PRODUCTION ESSENTIAL TECHNIQUES.", 1997, WILEY
ISHIDALONBERG, IBC'S 11TH ANTIBODY ENGINEERING, 2000
METHODS IN ENZYMOL., vol. 154, 1987, pages 3
STRATEGIES, vol. 5, 1992, pages 81
"Nucleic Acids Research", vol. 17, 1989, pages: 9494
DNA CLONING: A PRACTICAL APPROACH, vol. I, 1985, pages 49
MOL. CELL. BIOL., vol. 3, 1983, pages 280
GENETICS, vol. 39, 1954, pages 440
SCIENCE, vol. 222, 1983, pages 778
J. MOL. BIOL., vol. 166, 1983, pages 1
J. MOL. BIOL., vol. 16, 1966, pages 118
PROC. NATL. ACAD. SCI. USA, vol. 74, 1977, pages 5463
BIO/TECHNOLOGY, vol. 9, 1991, pages 266
CYTOTECHNOL, vol. 3, 1990, pages 133
J. BIOCHEM., vol. 101, 1987, pages 1307
PROC. NATL. ACAD. SCI. USA, vol. 78, 1981, pages 1527
CYTOTECHNOL., vol. 4, 1990, pages 173
BIOCHEM. BIOPHYS. RES. COMMUN., vol. 149, 1987, pages 960
CELL, vol. 41, 1985, pages 479
CELL, vol. 33, 1983, pages 717
HYBRIDOMA, vol. 17, 1998, pages 559
J. MOL. BIOL., vol. 112, 1977, pages 535
PROTEIN ENGINEERING, vol. 7, 1994, pages 1501
"Methods in Nucleic Acids Res.", 1991, CRC PRESS
"Monoclonal Antibodies-Principles and Practice", 1996, ACADEMIC PRESS
PROC. NATL. ACAD. SCI. USA, vol. 77, 1980, pages 4216
SOMATIC CELL AND MOLECULAR GENETICS, vol. 12, 1986, pages 55
NATURE, vol. 227, 1970, pages 680
EMMANUELLE LAFFY, HUMAN ANTIBODIES, vol. 14, 2005, pages 33 - 55
"enzyme immunoassay method", 1987, IGAKU-SHOIN LTD.
"Fluorescent Antibody Method", 1983, SOFT SCIENCE, INC.
"Bioluminescence and Chemiluminescence Clinical Test 42", 1998, HIROKAWA-SHOTEN LTD.
"Genbank", Database accession no. XM 015433685
ISHIDA, I. ET AL., CLONING & STEM CELLS, vol. 4, 2002, pages 85 - 96
ISAMU ISHIDA, EXPERIMENTAL MEDICINE, vol. 20, no. 6, 2002, pages 846 - 851
MOL IMMUNOL., vol. 33, no. 9, June 1996 (1996-06-01), pages 759 - 68
See also references of EP 3708589A4
YE, SHIMING ET AL.: "Enhancement of tumor specific immunity by activation of CD 40 through a biospecific molecule targeting CD 40 and a tumor surface antigen", JOURNAL FOR IMMUNO THERAPY OF CANCER, vol. 5, no. Suppl. 2 : 87, 7 November 2017 (2017-11-07), pages 182, XP009520353, DOI: 10.1186/s40425-017-0288-4
NUCLEIC ACIDS RESEARCH, vol. 25, 1997, pages 3389
SURESH, METHODS ENZYMOL., vol. 121, 1986, pages 210 - 228
KRANZ, J. HEMATOTHER., vol. 5, 1995, pages 403 - 408
WU, NAT. BIOTHECH., vol. 25, 2007, pages 1290 - 1297
CLARK, PNAS USA, vol. 83, 1986, pages 4494 - 4498
CHUNTHARAPAI, J. IMMUNOL., vol. 166, no. 8, 2001, pages 4891
ASHKENAZI, NAT REV CANCER, vol. 2, 2002, pages 420
KAWABE, IMMUNITY, vol. 1, 1994, pages 167 - 168
DIEHL LET., NAT MED., vol. 5, no. 7, July 1999 (1999-07-01), pages 774 - 9
BEATTY GL, EXPERT REV ANTICANCER THER., vol. 17, no. 2, February 2017 (2017-02-01), pages 175 - 186
VONDERHEIDE RH, ONCOIMMUNOLOGY, vol. 2, no. 1, 1 January 2013 (2013-01-01), pages e23033
BRIDGES, J IMMUMOL, vol. 139, 1987, pages 4242 - 4549
1541376565889_0, MOL CANCER., vol. 13, 17 April 2014 (2014-04-17), pages 85
VAN DER GUN BT, BR J CANCER, vol. 105, no. 2, 12 July 2011 (2011-07-12), pages 312 - 9
CHAUDRY MA, BR J CANCER, vol. 96, no. 7, 10 April 2007 (2007-04-10), pages 1013 - 9
MARKUS M, CANCER CELL INT., vol. 10, 2 November 2010 (2010-11-02), pages 44
LINKE R, MABS, vol. 2, no. 2, 2010, pages 129 - 136
"GenBank", Database accession no. NP _001035118
AGRIC. BIOL. CHEM., vol. 53, 1989, pages 277
NATURE, vol. 329, 1987, pages 840
NUCLEIC ACIDS RESEARCH, vol. 10, 1982, pages 6487
PROC. NATL. ACAD. SCI. USA, vol. 79, 1982, pages 6409
GENE, vol. 38, 1985, pages 275
NUCLEIC ACIDS RESEARCH, vol. 13, 1985, pages 4431
PROCEEDING OF THE NATIONAL ACADEMY OF SCIENCES IN USA, vol. 82, 1985, pages 488
"A Practical Approach", 1995, OXFORD UNIVERSITY, article "DNA Cloning 1: Core Techniques"
J. MOL. BIOL., vol. 215, 1990, pages 403
GENOME RESEARCH, vol. 7, 1997, pages 649, Retrieved from the Internet
ANNU. REV. IMMUNOL., vol. 9, 1991, pages 457 - 492
"Clinical oncology", JAPANESE JOURNAL OF CANCER AND CHEMOTHERAPY, 1996
"Antibodies - A Laboratory Manual", 1988, COLD SPRING HARBOR LABORATORY
NATURE PROTOCOLS, vol. 9, 2014, pages 2450 - 2463
PROC. NATL. ACAD. SCI., USA, vol. 79, 1982, pages 6409
PROC. NATL. ACAD. SCI USA, vol. 82, 1985, pages 488
BECK ET AL., ANALYTICAL CHEMISTRY, vol. 85, 2013, pages 715 - 736
CANCER IMMUNOL. IMMUNOTHER., vol. 36, 1993, pages 373
J. IMMUNOL. METHODS, vol. 167, 1994, pages 271
GENE, vol. 17, 1982, pages 107
CYTOTECHNOL., vol. 13, 1993, pages 79
GENE, vol. 27, 1984, pages 223
PROC. NATL. ACAD. SCI. USA, vol. 82, 1985, pages 4306
J. BACTERIOL., vol. 172, 1990, pages 2392
PROC. NATL. ACAD. SCI. USA, vol. 69, 1972, pages 2110
MOLECULAR & GENERAL GENETICS, vol. 168, 1979, pages 111
CYTOTECHNOLOGY, vol. 3, 1990, pages 133
J. BIOCHEMISTRY, vol. 101, 1987, pages 1307
PROC. NATL. ACAD. SCI. USA, vol. 84, 1987, pages 7413
THE JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, vol. 199, 1967, pages 519
SCIENCE, vol. 122, 1952, pages 501
VIROLOGY, vol. 8, 1959, pages 396
PROC. SOC. EXP. BIOL. MED., vol. 73, 1950, pages 1
PAULSON ET AL., J. BIOL. CHEM., vol. 264, 1989, pages 17619
LOWE ET AL., PROC. NATL. ACAD. SCI., USA, vol. 86, 1989, pages 8227
GENES DEVELOP., vol. 4, 1990, pages 1288
TOMIZUKA ET AL., PROC NATL ACAD SCI USA, vol. 97, 2000, pages 722
NATURE, vol. 276, 1978, pages 269
EUROPEAN J. IMMUNOLOGY, vol. 6, 1976, pages 511
J. IMMUNOLOGY, vol. 123, 1979, pages 1548
NATURE, vol. 256, 1975, pages 495
P. J. DELVES.: "ANTIBODY PRODUCTION ESSENTIAL TECHNIQUES.", 1997, WILEY
ISHIDALONBERG, IBC'S 11TH ANTIBODY ENGINEERING, 2000
METHODS IN ENZYMOL., vol. 154, 1987, pages 3
STRATEGIES, vol. 5, 1992, pages 81
"Nucleic Acids Research", vol. 17, 1989, pages: 9494
DNA CLONING: A PRACTICAL APPROACH, vol. I, 1985, pages 49
MOL. CELL. BIOL., vol. 3, 1983, pages 280
GENETICS, vol. 39, 1954, pages 440
SCIENCE, vol. 222, 1983, pages 778
J. MOL. BIOL., vol. 166, 1983, pages 1
J. MOL. BIOL., vol. 16, 1966, pages 118
PROC. NATL. ACAD. SCI. USA, vol. 74, 1977, pages 5463
BIO/TECHNOLOGY, vol. 9, 1991, pages 266
CYTOTECHNOL, vol. 3, 1990, pages 133
J. BIOCHEM., vol. 101, 1987, pages 1307
PROC. NATL. ACAD. SCI. USA, vol. 78, 1981, pages 1527
CYTOTECHNOL., vol. 4, 1990, pages 173
BIOCHEM. BIOPHYS. RES. COMMUN., vol. 149, 1987, pages 960
CELL, vol. 41, 1985, pages 479
CELL, vol. 33, 1983, pages 717
HYBRIDOMA, vol. 17, 1998, pages 559
J. MOL. BIOL., vol. 112, 1977, pages 535
PROTEIN ENGINEERING, vol. 7, 1994, pages 1501
"Methods in Nucleic Acids Res.", 1991, CRC PRESS
"Monoclonal Antibodies-Principles and Practice", 1996, ACADEMIC PRESS
PROC. NATL. ACAD. SCI. USA, vol. 77, 1980, pages 4216
SOMATIC CELL AND MOLECULAR GENETICS, vol. 12, 1986, pages 55
NATURE, vol. 227, 1970, pages 680
EMMANUELLE LAFFY, HUMAN ANTIBODIES, vol. 14, 2005, pages 33 - 55
"enzyme immunoassay method", 1987, IGAKU-SHOIN LTD.
"Fluorescent Antibody Method", 1983, SOFT SCIENCE, INC.
"Bioluminescence and Chemiluminescence Clinical Test 42", 1998, HIROKAWA-SHOTEN LTD.
"Genbank", Database accession no. XM 015433685
ISHIDA, I. ET AL., CLONING & STEM CELLS, vol. 4, 2002, pages 85 - 96
ISAMU ISHIDA, EXPERIMENTAL MEDICINE, vol. 20, no. 6, 2002, pages 846 - 851
MOL IMMUNOL., vol. 33, no. 9, June 1996 (1996-06-01), pages 759 - 68
See also references of EP 3708589A4
Attorney, Agent or Firm:
Eikoh Patent Firm, P.C. (JP)
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