Title:
BISPECIFIC ANTIBODY
Document Type and Number:
WIPO Patent Application WO/2020/204152
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a new drug for preventing, suppressing advance of symptoms, suppressing recurrence, or treating autoimmune disease. As a result of diligent studies, the inventors of the present invention focused on, inter alia, a PD-1/CD19 bispecific antibody as a substance capable of solving the problem, and confirmed that the bispecific antibody can serve as a new drug for preventing, suppressing advance of symptoms, suppressing recurrence, or treating autoimmune disease. The bispecific antibody was also confirmed to have a characteristic that allows interaction with PD-1 and PD-L1, which is a ligand of PD-1.
Inventors:
SHIBAYAMA SHIRO (JP)
TEZUKA TOMOYA (JP)
THROSBY MARK (NL)
DE KRUIF CORNELIS ADRIAAN (NL)
VAN LOO PIETER FOKKO (NL)
KLOOSTER RINSE (NL)
ROOVERS ROBERTUS CORNELIS (NL)
TEZUKA TOMOYA (JP)
THROSBY MARK (NL)
DE KRUIF CORNELIS ADRIAAN (NL)
VAN LOO PIETER FOKKO (NL)
KLOOSTER RINSE (NL)
ROOVERS ROBERTUS CORNELIS (NL)
Application Number:
PCT/JP2020/015266
Publication Date:
October 08, 2020
Filing Date:
April 03, 2020
Export Citation:
Assignee:
ONO PHARMACEUTICAL CO (JP)
International Classes:
A61K39/395; A61K45/00; A61P1/00; A61P1/16; A61P3/10; A61P5/00; A61P7/06; A61P9/00; A61P11/02; A61P11/06; A61P15/00; A61P17/00; A61P17/14; A61P19/02; A61P21/00; A61P25/00; A61P29/00; A61P37/02; A61P37/06; A61P37/08; C07K16/28; C07K16/46; C12N15/13
Domestic Patent References:
| WO2019070047A1 | 2019-04-11 | |||
| WO2008092117A2 | 2008-07-31 | |||
| WO2019009726A1 | 2019-01-10 | |||
| WO2009041613A1 | 2009-04-02 | |||
| WO2003011911A1 | 2003-02-13 | |||
| WO2004072286A1 | 2004-08-26 | |||
| WO2013022091A1 | 2013-02-14 | |||
| WO2002043478A2 | 2002-06-06 | |||
| WO2004009618A2 | 2004-01-29 | |||
| WO2009157771A2 | 2009-12-30 | |||
| WO2014051433A1 | 2014-04-03 | |||
| WO2000063403A2 | 2000-10-26 |
Foreign References:
| CN106939050A | 2017-07-11 | |||
| JP2011525808A | 2011-09-29 | |||
| JP2019500405A | 2019-01-10 | |||
| JP2008537941A | 2008-10-02 | |||
| CN106939050A | 2017-07-11 | |||
| US4474893A | 1984-10-02 | |||
| US4816567A | 1989-03-28 | |||
| US5223409A | 1993-06-29 | |||
| US5403484A | 1995-04-04 | |||
| US5571698A | 1996-11-05 | |||
| US5427908A | 1995-06-27 | |||
| US5580717A | 1996-12-03 | |||
| US5969108A | 1999-10-19 | |||
| US6172197B1 | 2001-01-09 | |||
| US5885793A | 1999-03-23 | |||
| US6521404B1 | 2003-02-18 | |||
| US6544731B1 | 2003-04-08 | |||
| US6555313B1 | 2003-04-29 | |||
| US6582915B1 | 2003-06-24 | |||
| US6593081B1 | 2003-07-15 | |||
| US5225539A | 1993-07-06 | |||
| US5530101A | 1996-06-25 | |||
| US5585089A | 1996-12-17 | |||
| US6180370B1 | 2001-01-30 | |||
| US5545806A | 1996-08-13 | |||
| US5569825A | 1996-10-29 | |||
| US5625126A | 1997-04-29 | |||
| US5633425A | 1997-05-27 | |||
| US5789650A | 1998-08-04 | |||
| US5877397A | 1999-03-02 | |||
| US5661016A | 1997-08-26 | |||
| US5814318A | 1998-09-29 | |||
| US5874299A | 1999-02-23 | |||
| US5770429A | 1998-06-23 | |||
| US5939598A | 1999-08-17 | |||
| US6075181A | 2000-06-13 | |||
| US6114598A | 2000-09-05 | |||
| US6150584A | 2000-11-21 | |||
| US6162963A | 2000-12-19 | |||
| US5476996A | 1995-12-19 | |||
| US5698767A | 1997-12-16 | |||
| EP0120694A2 | 1984-10-03 | |||
| EP0314161A1 | 1989-05-03 | |||
| EP0481790A2 | 1992-04-22 | |||
| EP0523949A1 | 1993-01-20 | |||
| US4801687A | 1989-01-31 | |||
| US5151504A | 1992-09-29 |
Other References:
SEBASTIAN KOBOLD; STANISLAV PANTELYUSHIN; FELICITAS RATAJ; JOHANNES VOM BERG: "Rationale for Combining Bispecific T Cell Activating Antibodies With Checkpoint Blockade for Cancer Therapy", FRONTIERS IN ONCOLOGY, vol. 8, 2018, XP055587431
"GenBank", Database accession no. NP 001171569
PROC. NATL. ACAD. SCI. USA, vol. 90, no. 14, 1993, pages 6444 - 6448
J. BIOLOGICAL CHEMISTRY, vol. 269, 1994, pages 199 - 206
BIOCHEMISTRY, vol. 31, no. 6, 1992, pages 1579 - 1584
KOHLERMILSTEIN ET AL., NATURE, vol. 256, 1975, pages 495 - 97
HONGO ET AL., HYBRIDOMA, vol. 14, no. 3, 1995, pages 253 - 260
HARLOW ET AL.: "Antibodies: A Laboratory Manual", vol. 2, 1988, COLD SPRING HARBOR LABORATORY PRESS
HAMMERLING ET AL.: "Monoclonal Antibodies and T-Cell Hybridomas", 1981, ELSEVIER, pages: 563 - 681
TOMIZUKA ET AL., PROC. NATL. ACAD. SCI. USA, 2000, pages 722 - 727
DE WILDT RM, J. MOL. BIOL., vol. 285, 1999, pages 895 - 901
DE KRUIF ET AL., J. MOL. BIOL., vol. 387, 2009, pages 548 - 58
COLIGAN JEDUNN BMPLOEGH HLSPEICHER DWWINGFIELD PT: "Practical Approach", 1991, IRL PRESS, article "Furthermore, general guidelines, procedures and practical methods to maximize the productivity of host cell culture can be carried out with reference to Mammalian Cell Biotechnology"
IMMUNOLOGY LETTERS, vol. 83, 2002, pages 215 - 220
See also references of EP 3978015A4
"GenBank", Database accession no. NP 001171569
PROC. NATL. ACAD. SCI. USA, vol. 90, no. 14, 1993, pages 6444 - 6448
J. BIOLOGICAL CHEMISTRY, vol. 269, 1994, pages 199 - 206
BIOCHEMISTRY, vol. 31, no. 6, 1992, pages 1579 - 1584
KOHLERMILSTEIN ET AL., NATURE, vol. 256, 1975, pages 495 - 97
HONGO ET AL., HYBRIDOMA, vol. 14, no. 3, 1995, pages 253 - 260
HARLOW ET AL.: "Antibodies: A Laboratory Manual", vol. 2, 1988, COLD SPRING HARBOR LABORATORY PRESS
HAMMERLING ET AL.: "Monoclonal Antibodies and T-Cell Hybridomas", 1981, ELSEVIER, pages: 563 - 681
TOMIZUKA ET AL., PROC. NATL. ACAD. SCI. USA, 2000, pages 722 - 727
DE WILDT RM, J. MOL. BIOL., vol. 285, 1999, pages 895 - 901
DE KRUIF ET AL., J. MOL. BIOL., vol. 387, 2009, pages 548 - 58
COLIGAN JEDUNN BMPLOEGH HLSPEICHER DWWINGFIELD PT: "Practical Approach", 1991, IRL PRESS, article "Furthermore, general guidelines, procedures and practical methods to maximize the productivity of host cell culture can be carried out with reference to Mammalian Cell Biotechnology"
IMMUNOLOGY LETTERS, vol. 83, 2002, pages 215 - 220
See also references of EP 3978015A4
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
Download PDF: