Title:
BISPECIFIC ANTIGEN-BINDING MOLECULE, COMPOSITION ASSOCIATED THEREWITH, AND USE, KIT, AND METHOD FOR PRODUCING COMPOSITION
Document Type and Number:
WIPO Patent Application WO/2021/210667
Kind Code:
A1
Abstract:
The present invention provides a bispecific antigen-binding molecule that recognizes both of two specific factors out of various coagulation-related factors, as well as a composition and a kit containing the bispecific antigen-binding molecule. In one non-limiting embodiment, the bispecific antigen-binding molecule, composition, and kit of the present invention are used to prevent and/or treat hemorrhaging, diseases accompanied by hemorrhaging, or diseases caused by hemorrhaging. Additionally, the present invention provides a method for using the bispecific antigen-binding molecule to promote coagulation. Furthermore, the present invention provides a screening method for substances that are effective for preventing and/or treating hemorrhaging, diseases accompanied by hemorrhaging, or diseases caused by hemorrhaging.
Inventors:
KOGA HIKARU (JP)
Application Number:
PCT/JP2021/015683
Publication Date:
October 21, 2021
Filing Date:
April 16, 2021
Export Citation:
Assignee:
CHUGAI PHARMACEUTICAL CO LTD (JP)
International Classes:
C07K16/36; A61K39/395; A61P7/04; C07K16/46; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/13; C12P21/08; C12Q1/56
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LANGER ET AL., J.BIOMED.MATER.RES., vol. 15, 1981, pages 267 - 277
LANGER, CHEMTECH, vol. 12, 1982, pages 98 - 105
SIDMAN ET AL., BIOPOLYMERS, vol. 22, 1983, pages 547 - 556
MOL ASPECTS MED, vol. 29, no. 4, August 2008 (2008-08-01), pages 203 - 254
THROMB. RES., vol. 161, January 2018 (2018-01-01), pages 94 - 105
J THROMB HAEMOST, vol. 3, no. 1, 2005, pages 54 - 67
BLOOD, vol. 115, no. 13, 2010, pages 2569 - 2577
NAT MED, vol. 18, no. 10, October 2012 (2012-10-01), pages 1570 - 4
BLOOD, vol. 127, no. 13, 2016, pages 1633 - 1641
NEW ENG J MED, vol. 21, 2016, pages 2044 - 2053
SEMIN THROMB HEMOST, vol. 44, no. 6, 2018, pages 578 - 589
J THROMB HAEMOST, vol. 11, no. 12, 2013, pages 2118 - 2127
J THROMB HAEMOST, vol. 16, no. 10, 2018, pages 2044 - 2049
HAEMOPHILIA, vol. 21, no. 4, 2015, pages 477 - 480
CLARKSON ET AL., NATURE, vol. 352, 1991, pages 624 - 628
KINDT ET AL.: "Kuby Immunology", 2007, W.H. FREEMAN AND CO., pages: 91
PORTOLANO ET AL., J. IMMUNOL., vol. 150, 1993, pages 880 - 887
CHOTHIALESK, J. MOL. BIOL., vol. 196, 1987, pages 901 - 917
MACCALLUM ET AL., J. MOL. BIOL., vol. 262, 1996, pages 732 - 745
BORREBAECK CAKLARRICK JW: "THERAPEUTIC MONOCLONAL ANTIBODIES", 1990, MACMILLAN PUBLISHERS LTD
HOLLIGER P ET AL., PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 6444 - 6448
MALLENDER WD ET AL., J. OF BIOLOGICAL CHEMISTRY, vol. 269, 1994, pages 199 - 206
MILSTEIN C ET AL., NATURE, vol. 305, 1983, pages 537 - 540
RIDGWAY, JB ET AL., PROTEIN ENGINEERING, vol. 9, 1996, pages 617 - 621
MERCHANT, AM ET AL.: "An efficient route to human bispecific IgG", NATURE BIOTECHNOLOGY, vol. 16, 1998, pages 677 - 681, XP002141015, DOI: 10.1038/nbt0798-677
KELER T ET AL., CANCER RESEARCH, vol. 57, 1997, pages 4008 - 4014
BRENNAN M ET AL., SCIENCE, vol. 229, 1985, pages 81 - 83
KOSTELNY SA ET AL., J. OF IMMUNOLOGY, vol. 148, 1992, pages 1547 - 53
HOLLIGER P ET AL., PROC. OF THE NATIONAL ACADEMY OF SCIENCES OF THE USA, vol. 90, 1993, pages 6444 - 6448
ZHU Z ET AL., PROTEIN SCIENCE, vol. 6, 1997, pages 781 - 788
KIPRIYANOV SM ET AL., J. OF MOLECULAR BIOLOGY, vol. 293, 1999, pages 41 - 56
SATO K ET AL., CANCER RESEARCH, vol. 53, 1993, pages 851 - 856
PROC NATL ACAD SCI USA., vol. 93, no. 15, 1996, pages 7843 - 7848
"Antibodies: A Laboratory Manual", 1988, COLD SPRING HARBOR LABORATORY
"Sequences of proteins of immunological interest", 1991, U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES
"Remington's Pharmaceutical Science", 1980
LANGER ET AL., J.BIOMED.MATER.RES., vol. 15, 1981, pages 267 - 277
LANGER, CHEMTECH, vol. 12, 1982, pages 98 - 105
SIDMAN ET AL., BIOPOLYMERS, vol. 22, 1983, pages 547 - 556
MOL ASPECTS MED, vol. 29, no. 4, August 2008 (2008-08-01), pages 203 - 254
THROMB. RES., vol. 161, January 2018 (2018-01-01), pages 94 - 105
J THROMB HAEMOST, vol. 3, no. 1, 2005, pages 54 - 67
BLOOD, vol. 115, no. 13, 2010, pages 2569 - 2577
Attorney, Agent or Firm:
HARUNA, Masao et al. (JP)
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