Title:
BISPECIFIC POLYPEPTIDE STRUCTURALLY BASED ON UTEROGLOBIN
Document Type and Number:
WIPO Patent Application WO/2019/176866
Kind Code:
A1
Abstract:
Provided is a low-molecular weight bispecific polypeptide. A heterodimer uteroglobin is prepared by modifying, to a low-molecular weight uteroglobin, an Fc region in a bispecific antibody constructed from a natural antibody, and causing a uteroglobin monomer to be mutated, and a bispecific polypeptide is constructed by using the same.
Inventors:
NIIYAMA MAYUMI (JP)
AKIBA HIROKI (JP)
ABE YASUHIRO (JP)
NAGATA SATOSHI (JP)
ISE TOMOKO (JP)
NAGAO CHIOKO (JP)
KAMADA HARUHIKO (JP)
TSUMOTO KOHEI (JP)
MIZUGUCHI KENJI (JP)
AFANASEVA ARINA (JP)
INOUE TSUYOSHI (JP)
FUKUDA YOHTA (JP)
AKIBA HIROKI (JP)
ABE YASUHIRO (JP)
NAGATA SATOSHI (JP)
ISE TOMOKO (JP)
NAGAO CHIOKO (JP)
KAMADA HARUHIKO (JP)
TSUMOTO KOHEI (JP)
MIZUGUCHI KENJI (JP)
AFANASEVA ARINA (JP)
INOUE TSUYOSHI (JP)
FUKUDA YOHTA (JP)
Application Number:
PCT/JP2019/009745
Publication Date:
September 19, 2019
Filing Date:
March 11, 2019
Export Citation:
Assignee:
NAT INST BIOMEDICAL INNOVATION HEALTH & NUTRITION (JP)
UNIV OSAKA (JP)
UNIV OSAKA (JP)
International Classes:
C12N15/12; A61K38/17; A61P35/00; C07K14/47; C07K19/00; C12N1/21; C12N15/62; C12P21/02; A61K39/395
Foreign References:
| JP2002521316A | 2002-07-16 | |||
| US20130189735A1 | 2013-07-25 |
Other References:
SPIESS, C. ET AL.: "Bispecific antibodies with natural architecture produced by co-culture of bacterial expressing two distinct half-antibodies", NATURE BIOTECHNOLOGY, vol. 31, no. 8, 2013, pages 753 - 758, XP055127867, DOI: 10.1038/nbt.2621
MUKHERJEE, A. B. ET AL.: "Uteroglobin: a novel cytokine?, CMLS", CELL . MOL. LIFE SCI., vol. 55, 1999, pages 771 - 787, XP000961126, DOI: 10.1007/s000180050331
VENTURA, E. ET AL.: "Use of the Uteroglobin Platform for the Expression of a Bivalent Antibody against Oncofetal Fibronectin in Escherichia coli", PLOS ONE, vol. 8, no. 12, 2013, pages 1 - 10, XP055636126
vol. 07, no. 10, 2 February 2018 (2018-02-02), pages 7, Retrieved from the Internet
MUKHERJEE, A. B. ET AL.: "Uteroglobin: a novel cytokine?, CMLS", CELL . MOL. LIFE SCI., vol. 55, 1999, pages 771 - 787, XP000961126, DOI: 10.1007/s000180050331
VENTURA, E. ET AL.: "Use of the Uteroglobin Platform for the Expression of a Bivalent Antibody against Oncofetal Fibronectin in Escherichia coli", PLOS ONE, vol. 8, no. 12, 2013, pages 1 - 10, XP055636126
vol. 07, no. 10, 2 February 2018 (2018-02-02), pages 7, Retrieved from the Internet
Attorney, Agent or Firm:
YAMAO, Norihito et al. (JP)
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