Title:
BISTRIFILATE-BASED FLUOROGENIC PROBES FOR DETECTION OF SUPEROXIDE ANION RADICAL
Document Type and Number:
WIPO Patent Application WO/2015/113455
Kind Code:
A1
Abstract:
The invention provides fluorogenic compounds and probes that can be used as reagents for measuring, detecting and/or screening superoxide. The fluorogenic compounds of the invention can produce fluorescence colors, such as green, yellow, red, or far-red. The invention further provides fluorogenic compounds for selectively staining superoxide in the mitochondria of living cells. The invention also provides methods that can be used to measure, directly or indirectly, the presence and/or amount of superoxide in chemical samples and biological samples such as cells and tissues in living organisms, and a high-throughput screening methods for detecting or screening superoxide or compounds that can increase or decrease the level of superoxide in chemical and biological samples.
Inventors:
YANG DAN (CN)
HU JUN (CN)
WONG NAI KEI (CN)
HU JUN (CN)
WONG NAI KEI (CN)
Application Number:
PCT/CN2015/000072
Publication Date:
August 06, 2015
Filing Date:
January 30, 2015
Export Citation:
Assignee:
UNIV HONG KONG (CN)
International Classes:
C07D407/02; B41M5/20; B41M5/327; C07F7/08; C07F7/10
Domestic Patent References:
| WO2013113279A1 | 2013-08-08 |
Foreign References:
| CN102146284A | 2011-08-10 |
Other References:
BRYAN C. DICKINSON ET AL.: "A Palette of Fluorescent Probes with Varying Emission Colors for Imaging Hydrogen Peroxide Signaling in Living Cells", J. AM. CHEM. SOC., vol. 132, 2 April 2010 (2010-04-02), pages 5906 - 5915, XP055216569
See also references of EP 3099680A4
See also references of EP 3099680A4
Attorney, Agent or Firm:
CHINA PATENT AGENT (H.K.) LTD. (CN)
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