BIVALENT ANTIBODY HAVING SINGLE-DOMAIN ANTIGEN-BINDING FRAGMENT FUSED TO CONVENTIONAL FAB FRAGMENT

Title:

BIVALENT ANTIBODY HAVING SINGLE-DOMAIN ANTIGEN-BINDING FRAGMENT FUSED TO CONVENTIONAL FAB FRAGMENT

Document Type and Number:

WIPO Patent Application WO/2016/192613

Kind Code:

A1

Abstract:

Provided is a bivalent antibody, comprising: (a) an antigen-binding fragment (Fab) comprising a light chain and a portion of a heavy chain of the antibody, and (b) a single-domain antigen-binding fragment (VHH) fused to a C terminal of the light chain or the portion of the heavy chain, wherein the portion of the heavy chain does not comprise a CH2 or CH3 domain.

Inventors:

WANG ZHONG (CN)

Application Number:

PCT/CN2016/084003

Publication Date:

December 08, 2016

Filing Date:

May 31, 2016

Export Citation:

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Assignee:

UNIV SUN YAT SEN (CN)

International Classes:

A61K39/395; C07K16/46; A61P35/00; C12N1/19; C12N1/21

Foreign References:

CN102164965A	2011-08-24
CN102639566A	2012-08-15

Attorney, Agent or Firm:

WINGUAN PATENT AND TRADEMARK ATTORNEYS (CN)
广州市天河区倪律专利代理事务所（普通合伙） (CN)

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