Title:
BLOCK COPOLYMER HAVING PHENYLBORONIC ACID GROUP INTRODUCED THEREIN, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2013/073697
Kind Code:
A1
Abstract:
The present invention provides a block copolymer which can act as a carrier that can achieve both the stability of a biotechnology-based drug in blood and the release of the biotechnology-based drug at an affected area. The block copolymer according to the present invention comprises a polyamino acid chain segment and a hydrophilic polymer chain segment, wherein the polyamino acid chain segment contains an amino acid residue having a cationic group in a side chain thereof and an amino acid residue having a phenylboronic acid group in a side chain thereof, wherein at least one hydrogen atom in a phenyl ring in the phenylboronic acid group is substituted so that the resultant block copolymer can have a pKa value close to the physiological pH value.
Inventors:
KATAOKA KAZUNORI (JP)
ISHII TAKEHIKO (JP)
NAITO MITSURU (JP)
MATSUMOTO AKIRA (JP)
KATO YASUKI (JP)
ISHII TAKEHIKO (JP)
NAITO MITSURU (JP)
MATSUMOTO AKIRA (JP)
KATO YASUKI (JP)
Application Number:
PCT/JP2012/079897
Publication Date:
May 23, 2013
Filing Date:
November 19, 2012
Export Citation:
Assignee:
UNIV TOKYO (JP)
NAT UNIV CORP TOKYO MED & DENT (JP)
NANOCARRIER CO LTD (JP)
NAT UNIV CORP TOKYO MED & DENT (JP)
NANOCARRIER CO LTD (JP)
International Classes:
C08G81/00
Domestic Patent References:
| WO2009133647A1 | 2009-11-05 |
Foreign References:
| JP2002179683A | 2002-06-26 | |||
| JP2011173960A | 2011-09-08 | |||
| JP2011140537A | 2011-07-21 | |||
| JP2002179683A | 2002-06-26 |
Other References:
FUMIKO NAKANOWATARI ET AL.: "Micelle formation from PEG-p(Lys) block copolymer with phenyl boronic acid moieties", POLYMER PREPRINTS, JAPAN, vol. 48, no. 3, 12 May 1999 (1999-05-12), pages 572, XP008173084
KAZUNORI KATAOKA: "Cellular specific material and new drug delivery system", POLYFILE, vol. 30, no. 350, April 1993 (1993-04-01), pages 27 - 31, XP008174127
MITSURU NAITO ET AL.: "Ribose to Kagyaku Ketsugosei o Yusuru Phenylboronic Acid o Riyo shita Kobunshi Micelle-gata siRNA Delivery Carrier no Sekkei to Kino Hyoka", POLYMER PREPRINTS, JAPAN, vol. 61, no. 1, 15 May 2012 (2012-05-15), pages 1642, XP008173086
L.ZHAO ET AL.: "Glucose-sensitive polypeptide micelles for self-regulated insulin release at physiological pH", J. MATER. CHEM., vol. 22, 2012, pages 12319 - 12328, XP055150110
See also references of EP 2781536A4
KAZUNORI KATAOKA: "Cellular specific material and new drug delivery system", POLYFILE, vol. 30, no. 350, April 1993 (1993-04-01), pages 27 - 31, XP008174127
MITSURU NAITO ET AL.: "Ribose to Kagyaku Ketsugosei o Yusuru Phenylboronic Acid o Riyo shita Kobunshi Micelle-gata siRNA Delivery Carrier no Sekkei to Kino Hyoka", POLYMER PREPRINTS, JAPAN, vol. 61, no. 1, 15 May 2012 (2012-05-15), pages 1642, XP008173086
L.ZHAO ET AL.: "Glucose-sensitive polypeptide micelles for self-regulated insulin release at physiological pH", J. MATER. CHEM., vol. 22, 2012, pages 12319 - 12328, XP055150110
See also references of EP 2781536A4
Attorney, Agent or Firm:
MOMII, Takafumi (JP)
Takafumi Momii (JP)
Takafumi Momii (JP)
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