BLOCKADE OF MTOR TO PREVENT A HORMONAL ADAPTIVE RESPONSE

Title:

BLOCKADE OF MTOR TO PREVENT A HORMONAL ADAPTIVE RESPONSE

Document Type and Number:

WIPO Patent Application WO2005018562

Kind Code:

A3

Abstract:

One embodiment of the present invention is directed to the use of an mTOR inhibitor, such as farnesylthiosalicylic acid (FTS), to prevent a hormonal adaptive response during hormonal deprivation treatment of a hormonal responsive cancer. FIG. 4 represents the effect of FTS on E2 stimulated growth of MCF-7 and LTED cells.

Inventors:

SANTEN RICHARD J (US)
YUE WEI (US)
LAWRENCE JOHN C JR (US)
MCMAHON LLOYD P (US)

Application Number:

PCT/US2004/027016

Publication Date:

December 29, 2005

Filing Date:

August 20, 2004

Export Citation:

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Assignee:

UNIV VIRGINIA (US)
SANTEN RICHARD J (US)
YUE WEI (US)
LAWRENCE JOHN C JR (US)
MCMAHON LLOYD P (US)

International Classes:

A61K31/135; A61K31/20; A61K; (IPC1-7): A61K31/20; A61K31/135

Other References:

DATABASE MEDLINE [online] June 2003 (2003-06-01), BERSTEIN L. ET AL.: "New approaches to the understanding of tamoxifen action and resistance.", XP002999288, accession no. STN Database accession no. 2003265200
DATABASE CAPLUS [online] 11 April 2002 (2002-04-11), KLOOG Y. ET AL.: "Drug screening for inhibitors of Ras binding to galectins and their therapeutic use as anti-tumor agents.", XP002999289, accession no. STN Database accession no. 2002:276136
DATABASE MEDLINE [online] February 2002 (2002-02-01), GANA-WEISZ M. ET AL.: "The RAs inhibitor S-trans-farnesylthiosalicylic acid chemosensitizes human tumor cells without resistance.", XP002999290, accession no. STN Database accession no. 2002147837

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