Title:
BLOCKERS OF THE GROWTH HORMONE RECEPTOR IN DISEASE PREVENTION AND TREATMENT
Document Type and Number:
WIPO Patent Application WO/2016/130901
Kind Code:
A3
Abstract:
Compounds and methods for treating diseases or conditions affected by the activity or expression of genes/proteins related to human GH, GHR, STAT5, SOCS, IGF-1, insulin are provided. Monoclonal antibodies for treating diseases or conditions related to growth hormone and growth hormone receptor activity are also provided.
Inventors:
LONGO VALTER D (US)
BALASUBRAMANIAN PRIYA (US)
NEAMATI NOURI (US)
WEI MIN (US)
BALASUBRAMANIAN PRIYA (US)
NEAMATI NOURI (US)
WEI MIN (US)
Application Number:
PCT/US2016/017717
Publication Date:
October 20, 2016
Filing Date:
February 12, 2016
Export Citation:
Assignee:
UNIV SOUTHERN CALIFORNIA (US)
International Classes:
C07D405/12; A61K31/4184; A61K31/4245; A61K31/55; A61K39/395; A61P25/00; A61P25/28; C07D405/14
Domestic Patent References:
| WO2006001770A1 | 2006-01-05 |
Other References:
DATABASE Chemical Abstract 28 August 2011 (2011-08-28), XP055476025, retrieved from STN Database accession no. 1324757-41-6
DATABASE Chemical Abstract 29 July 2009 (2009-07-29), XP055476066, retrieved from STN Database accession no. 1169951-41-0
DATABASE Chemical Abstract 26 December 2008 (2008-12-26), XP055476068, retrieved from STN Database accession no. 1090351-93-1
DATABASE Chemical Abstract 2 April 2008 (2008-04-02), XP055476081, retrieved from STN Database accession no. 1011657-63-8
ROSENGREN, L. ET AL.: "In vivo evaluation of a novel, orally bioavailable, small molecule growth hormone receptor antagonist", GROWTH HORMONE & IGF RESEARCH, vol. 17, no. 1, 2007, pages 47 - 53, XP005906246
DATABASE Chemical Abstract 29 July 2009 (2009-07-29), XP055476066, retrieved from STN Database accession no. 1169951-41-0
DATABASE Chemical Abstract 26 December 2008 (2008-12-26), XP055476068, retrieved from STN Database accession no. 1090351-93-1
DATABASE Chemical Abstract 2 April 2008 (2008-04-02), XP055476081, retrieved from STN Database accession no. 1011657-63-8
ROSENGREN, L. ET AL.: "In vivo evaluation of a novel, orally bioavailable, small molecule growth hormone receptor antagonist", GROWTH HORMONE & IGF RESEARCH, vol. 17, no. 1, 2007, pages 47 - 53, XP005906246
Attorney, Agent or Firm:
PROSCIA, James W. et al. (1000 Town CenterTwenty-Second Floo, Southfield Michigan, US)
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