Title:
BLOOD-BRAIN BARRIER (BBB) PENETRATING DUAL SPECIFIC BINDING PROTEINS
Document Type and Number:
WIPO Patent Application WO/2014/089209
Kind Code:
A3
Abstract:
Engineered multivalent and multispecific binding proteins capable of penetrating the blood-brain barrier (BBB) are provided, along with methods of making and uses in the prevention, diagnosis, and/or treatment of disease.
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Inventors:
HANZATIAN DENISE KARAOGLU (US)
GHAYUR TARIQ (US)
STERMAN ANNETTE J SCHWARTZ (US)
GOODEARL ANDREW (US)
HARRIS MARIA CRISTINA (US)
GHAYUR TARIQ (US)
STERMAN ANNETTE J SCHWARTZ (US)
GOODEARL ANDREW (US)
HARRIS MARIA CRISTINA (US)
Application Number:
PCT/US2013/073114
Publication Date:
August 21, 2014
Filing Date:
December 04, 2013
Export Citation:
Assignee:
ABBVIE INC (US)
International Classes:
C07K16/18; A61K39/00; A61P25/00; C07K16/24; C07K16/28; C07K16/32; C07K16/42
Domestic Patent References:
| WO2012075037A1 | 2012-06-07 | |||
| WO2011059755A2 | 2011-05-19 |
Other References:
FRIDEN P M ET AL: "ANTI-TRANSFERRIN RECEPTOR ANTIBODY AND ANTIBODY-DRUG CONJUGATES CROSS THE BLOOD-BRAIN BARRIER", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, US, vol. 88, no. 11, 1 June 1991 (1991-06-01), pages 4771 - 4775, XP000371714, ISSN: 0027-8424, DOI: 10.1073/PNAS.88.11.4771
PARDRIDGE ET AL: "Blood-brain barrier delivery of protein and non-viral gene therapeutics with molecular Trojan horses", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, vol. 122, no. 3, 18 September 2007 (2007-09-18), pages 345 - 348, XP022336567, ISSN: 0168-3659, DOI: 10.1016/J.JCONREL.2007.04.001
PARDRIDGE WILLIAM M: "Biologic TNF[alpha]-inhibitors that cross the human blood-brain barrier", BIOENGINEERED BUGS, LANDES BIOSCIENCE, US, vol. 1, no. 4, 1 July 2010 (2010-07-01), pages 231 - 234, XP002669295, ISSN: 1949-1018
BOADO R J ET AL: "Fusion antibody for Alzheimer's disease with bidirectional transport across the blood-brain barrier and A[beta] fibril disaggregation", BIOCONJUGATE CHEMISTRY, ACS, WASHINGTON, DC, US, vol. 18, no. 2, 1 March 2007 (2007-03-01), pages 447 - 455, XP002610311, ISSN: 1043-1802, [retrieved on 20070222], DOI: 10.1021/BC060349X
Y. ZHANG ET AL: "Delivery of -Galactosidase to Mouse Brain via the Blood-Brain Barrier Transferrin Receptor", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 313, no. 3, 1 June 2005 (2005-06-01), pages 1075 - 1081, XP055111828, ISSN: 0022-3565, DOI: 10.1124/jpet.104.082974
GU JIJIE ET AL: "GENERATION OF DUAL-VARIABLE-DOMAIN IMMUNOGLOBULIN MOLECULES FOR DUAL-SPECIFIC TARGETING", METHODS IN ENZYMOLOGY; [METHODS IN ENZYMOLOGY], ACADEMIC PRESS, US, vol. 502, 1 January 2012 (2012-01-01), pages 25 - 41, XP009168885, ISSN: 0076-6879
PARDRIDGE ET AL: "Blood-brain barrier delivery of protein and non-viral gene therapeutics with molecular Trojan horses", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, vol. 122, no. 3, 18 September 2007 (2007-09-18), pages 345 - 348, XP022336567, ISSN: 0168-3659, DOI: 10.1016/J.JCONREL.2007.04.001
PARDRIDGE WILLIAM M: "Biologic TNF[alpha]-inhibitors that cross the human blood-brain barrier", BIOENGINEERED BUGS, LANDES BIOSCIENCE, US, vol. 1, no. 4, 1 July 2010 (2010-07-01), pages 231 - 234, XP002669295, ISSN: 1949-1018
BOADO R J ET AL: "Fusion antibody for Alzheimer's disease with bidirectional transport across the blood-brain barrier and A[beta] fibril disaggregation", BIOCONJUGATE CHEMISTRY, ACS, WASHINGTON, DC, US, vol. 18, no. 2, 1 March 2007 (2007-03-01), pages 447 - 455, XP002610311, ISSN: 1043-1802, [retrieved on 20070222], DOI: 10.1021/BC060349X
Y. ZHANG ET AL: "Delivery of -Galactosidase to Mouse Brain via the Blood-Brain Barrier Transferrin Receptor", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 313, no. 3, 1 June 2005 (2005-06-01), pages 1075 - 1081, XP055111828, ISSN: 0022-3565, DOI: 10.1124/jpet.104.082974
GU JIJIE ET AL: "GENERATION OF DUAL-VARIABLE-DOMAIN IMMUNOGLOBULIN MOLECULES FOR DUAL-SPECIFIC TARGETING", METHODS IN ENZYMOLOGY; [METHODS IN ENZYMOLOGY], ACADEMIC PRESS, US, vol. 502, 1 January 2012 (2012-01-01), pages 25 - 41, XP009168885, ISSN: 0076-6879
Attorney, Agent or Firm:
VELEMA, James, H. et al. (28 State StreetBoston, MA, US)
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