Title:
BLOOD-BRAIN BARRIER (BBB) PENETRATING DUAL SPECIFIC BINDING PROTEINS FOR TREATING BRAIN AND NEUROLOGICAL DISEASES
Document Type and Number:
WIPO Patent Application WO/2015/191934
Kind Code:
A8
Abstract:
Engineered agents or multivalent and multispecific binding proteins capable of penetrating the cells or tissue of the blood-brain barrier (BBB) are provided, along with methods of making and uses in the prevention, diagnosis, and/or treatment of disease.
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Inventors:
HANZATIAN DENISE KARAOGLU (US)
GOODEARL ANDREW D (US)
MUELLER BERNHARD KLAUSE (DE)
MUELLER REINHOLD (DE)
KLEIN CORINNA (DE)
GOODEARL ANDREW D (US)
MUELLER BERNHARD KLAUSE (DE)
MUELLER REINHOLD (DE)
KLEIN CORINNA (DE)
Application Number:
PCT/US2015/035441
Publication Date:
February 25, 2016
Filing Date:
June 11, 2015
Export Citation:
Assignee:
ABBVIE INC (US)
International Classes:
C07K16/24; A61K39/00; A61P25/00; A61P25/04; A61P25/10; A61P25/28; A61P35/00; C07K16/28; C07K16/42
Attorney, Agent or Firm:
MCDONELL, Leslie A. et al. (Henderson Farabow, Garrett & Dunner, LLP,901 New York Avenue, N, Washington D.C., US)
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