Title:
BLOOD-BRAIN BARRIER PERMEABLE APTAMER AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/045816
Kind Code:
A1
Abstract:
The present invention relates to a blood-brain barrier (BBB)-permeable aptamer and an application thereof to a complex in which a material selectively binding to a target material present in the brain is conjugated therewith. The aptamer and the complex having the aptamer conjugated thereto according to the present invention can be used as a radioactive contrast agent for positron emission tomography (PET) for early diagnosis of Alzheimer's disease or Parkinson's disease, can be used as a radioactive contrast material that permeates through BBB to make an early contrast of the distribution of a target material in the brain parenchyma through PET, and can be used as a therapeutic agent for degenerative brain disease.
Inventors:
SON IN SIK (KR)
Application Number:
PCT/KR2019/008148
Publication Date:
March 05, 2020
Filing Date:
July 03, 2019
Export Citation:
Assignee:
NEXMOS CO LTD (KR)
International Classes:
C12N15/115; A61K31/7088; A61K51/04; A61P25/16; A61P25/28
Foreign References:
| KR20170041289A | 2017-04-14 | |||
| US20180057605A1 | 2018-03-01 | |||
| US20090047300A1 | 2009-02-19 | |||
| KR20140019091A | 2014-02-14 |
Other References:
C HENG, C.: "In vivo SELEX for Identification of Brain-penetrating Aptamers", MOL. THER. NUCLEIC ACIDS, 2013, XP055145010
CHEN, C.-H. B.: "Aptamer-based endocytosis of a lysosomal enzyme", PNAS, 14 October 2008 (2008-10-14), pages 15908 - 15913, XP055080683, DOI: 10.1073/pnas.0808360105
CHEN, C.-H. B.: "Aptamer-based endocytosis of a lysosomal enzyme", PNAS, 14 October 2008 (2008-10-14), pages 15908 - 15913, XP055080683, DOI: 10.1073/pnas.0808360105
Attorney, Agent or Firm:
KOO, Hyun Seo (KR)
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