Title:
BLOOD FLOW IMPROVER
Document Type and Number:
WIPO Patent Application WO/2019/031442
Kind Code:
A1
Abstract:
Provided is a blood flow improver which is safe and has a mild action. This blood flow improver comprises S-1-propenylcysteine or a salt thereof as an active ingredient.
Inventors:
USHIJIMA MITSUYASU (JP)
KUNIMURA KAYO (JP)
KODERA YUKIHIRO (JP)
MORIHARA NAOAKI (JP)
KUNIMURA KAYO (JP)
KODERA YUKIHIRO (JP)
MORIHARA NAOAKI (JP)
Application Number:
PCT/JP2018/029386
Publication Date:
February 14, 2019
Filing Date:
August 06, 2018
Export Citation:
Assignee:
WAKUNAGA PHARMA CO LTD (JP)
International Classes:
A61K31/198; A23L33/10; A61K36/8962; A61P9/00; A61P19/02; A61P21/00
Domestic Patent References:
| WO2016088892A1 | 2016-06-09 | |||
| WO2016088892A1 | 2016-06-09 | |||
| WO2016199885A1 | 2016-12-15 |
Foreign References:
| KR20170041568A | 2017-04-17 | |||
| JPH0560447B2 | 1993-09-02 | |||
| JP4255138B2 | 2009-04-15 |
Other References:
OKUHARA TANEOMI: "Clinical review on peripheral circulation of GE", JAPANESE PHARMACOLOGY & THERAPEUTICS. SUPPL., vol. 22, no. 8, pages 335 - 341
ANIM-NYAME, N ET AL.: "Garlic supplementation increases peripheral blood flow: a role for interleukin-6", THE JOURNAL OF NUTRITIONAL BIOCHEMISTRY, vol. 15, no. 1, 2004, pages 30 - 36, XP055576025
KODERA, Y ET AL.: "Chemical and biological properties of S-l-propenyl-L-Cysteine in aged garlic extract", MOLECULES, vol. 22, no. 4, March 2017 (2017-03-01), pages E570, XP055576029
USHIJIMA, M ET AL.: "Effects of S-l-propenylcysteine, a sulfur compound in aged garlic extract, on blood pressure and peripheral circulation in spontaneously hypertensive rats", JOURNAL OF PHARMACY AND PHARMACOLOGY, vol. 70, no. 4, April 2018 (2018-04-01), pages 559 - 565, XP055576032, DOI: doi: 10.1111/jphp.12865
"Ninniku no Kagaku (in Japanese, The Science of Garlic", 2000, ASAKURA PUBLISHING CO., LTD., pages: 93 - 122
PHYTOTHER RES., vol. 3, 1989, pages 50 - 53
CARCINOGENESIS, vol. 17, no. 5, 1996, pages 1041 - 1044
AM. J. PHYSIOL. RENAL PHYSIOL., vol. 293, 2007, pages F1691 - F1698
H NISHIMURAA MIZUGUCHIJ MIZUTANI: "Stereoselective synthesis of S-(trans-prop-1-enyl)-cysteine sulphoxide", TETRAHEDRON LETTER, vol. 37, 1975, pages 3201 - 3202
JC NAMYSLOC STANITZEK: "A palladium-catalyzed synthesis of isoalliin, the main cysteine sulfoxide in Onion (Allium cepa", SYNTHESIS, vol. 20, 2006, pages 3367 - 3369
S LEEJN KIMDH CHOUNGHK LEE: "Facile synthesis of trans-S-l-propenyl-L-cysteine sulfoxide (isoalliin) in onions (Allium cepa", BULL. KOREAN CHEM. SOC., vol. 32, no. 1, 2011, pages 319 - 320, XP002780689
See also references of EP 3666269A4
ANIM-NYAME, N ET AL.: "Garlic supplementation increases peripheral blood flow: a role for interleukin-6", THE JOURNAL OF NUTRITIONAL BIOCHEMISTRY, vol. 15, no. 1, 2004, pages 30 - 36, XP055576025
KODERA, Y ET AL.: "Chemical and biological properties of S-l-propenyl-L-Cysteine in aged garlic extract", MOLECULES, vol. 22, no. 4, March 2017 (2017-03-01), pages E570, XP055576029
USHIJIMA, M ET AL.: "Effects of S-l-propenylcysteine, a sulfur compound in aged garlic extract, on blood pressure and peripheral circulation in spontaneously hypertensive rats", JOURNAL OF PHARMACY AND PHARMACOLOGY, vol. 70, no. 4, April 2018 (2018-04-01), pages 559 - 565, XP055576032, DOI: doi: 10.1111/jphp.12865
"Ninniku no Kagaku (in Japanese, The Science of Garlic", 2000, ASAKURA PUBLISHING CO., LTD., pages: 93 - 122
PHYTOTHER RES., vol. 3, 1989, pages 50 - 53
CARCINOGENESIS, vol. 17, no. 5, 1996, pages 1041 - 1044
AM. J. PHYSIOL. RENAL PHYSIOL., vol. 293, 2007, pages F1691 - F1698
H NISHIMURAA MIZUGUCHIJ MIZUTANI: "Stereoselective synthesis of S-(trans-prop-1-enyl)-cysteine sulphoxide", TETRAHEDRON LETTER, vol. 37, 1975, pages 3201 - 3202
JC NAMYSLOC STANITZEK: "A palladium-catalyzed synthesis of isoalliin, the main cysteine sulfoxide in Onion (Allium cepa", SYNTHESIS, vol. 20, 2006, pages 3367 - 3369
S LEEJN KIMDH CHOUNGHK LEE: "Facile synthesis of trans-S-l-propenyl-L-cysteine sulfoxide (isoalliin) in onions (Allium cepa", BULL. KOREAN CHEM. SOC., vol. 32, no. 1, 2011, pages 319 - 320, XP002780689
See also references of EP 3666269A4
Attorney, Agent or Firm:
THE PATENT CORPORATE BODY ARUGA PATENT OFFICE (JP)
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