Title:
BLOOD FLOW PROMOTING AGENT
Document Type and Number:
WIPO Patent Application WO/2014/069660
Kind Code:
A1
Abstract:
In addition to applications in athletic performance improvement, fat accumulation suppression, and skin quality improvement in connection with the peripheral vasodilatation, this blood flow promoting agent can also be applied to ensuring blood circulation in ischemic diseases, relaxation of blood vessels predisposed to contraction due to age or lifestyle-related diseases, arteriosclerosis prevention, and prevention of shoulder stiffness caused by impaired blood flow, over-sensitivity to cold, erectile dysfunction, thrombosis, etc. This blood flow promoting agent is safe even when dosed over a long period of time, contains, as active components, citrulline or a salt thereof and capsaicin or a capsaicinoid, and in particular exhibits a vasodilating action effective at low doses at which capsaicin does not cause irritation. Also provided are health-promoting foods and functional foods from which the action of this blood flow promoting agent may be obtained.
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Inventors:
MORITA MASAHIKO (JP)
KAMIMURA AYAKO (JP)
KOBAYASHI YOSHINORI (JP)
KAMIMURA AYAKO (JP)
KOBAYASHI YOSHINORI (JP)
Application Number:
PCT/JP2013/079904
Publication Date:
May 08, 2014
Filing Date:
November 05, 2013
Export Citation:
Assignee:
KYOWA HAKKO BIO CO LTD (JP)
International Classes:
A61K31/198; A61K8/42; A61K31/17; A61P3/06; A61P9/00; A61P9/08; A61P9/10; A61P17/00; A61P17/16; A61P43/00; A61Q19/00
Other References:
RUIZ E. ET AL.: "Relaxant effects of L-citrulline in rabbit vascular smooth muscle", BR J PHARMACOL, vol. 125, 1998, pages 186 - 192
YANG D. ET AL.: "Activation of TRPV1 by dietary capsaicin improves endothelium-dependent vasorelaxation and prevents hypertension.", CELL METAB, vol. 12, no. 2, 2010, pages 130 - 141
YANG D. ET AL.: "Activation of TRPV1 by dietary capsaicin improves endothelium-dependent vasorelaxation and prevents hypertension.", CELL METAB, vol. 12, no. 2, 2010, pages 130 - 141
Attorney, Agent or Firm:
TAKASHIMA, HAJIME (JP)
Takashima 1 (JP)
Takashima 1 (JP)
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