Title:
BLOOD IMAGING
Document Type and Number:
WIPO Patent Application WO/2009/140743
Kind Code:
A3
Abstract:
The invention generally relates to the application of imaging techniques, in particular positron emission tomography (PET) or single photon emission tomography (SPECT), in the assessment of physiological parameters in a subject. The compounds of the present invention were shown to be cell membrane permeant and to have a specific binding affinity (or substrate affinity) for the carbonic anhydrases type I and II, and are accordingly useful for the in vivo and in vitro labeling of erythrocytes (RBC). It is accordingly an object of the present invention to provide said novel compounds, in particular the radio labeled variants thereof, and their use in imaging techniques to perform the assessment of physiological parameters, such as blood volume measurements, or blood flow measurements.
Inventors:
BORMANS GUY (BE)
VERBRUGGEN ALFONS (BE)
VERBRUGGEN ALFONS (BE)
Application Number:
PCT/BE2009/000027
Publication Date:
June 24, 2010
Filing Date:
May 25, 2009
Export Citation:
Assignee:
UNIV LEUVEN KATH (BE)
BORMANS GUY (BE)
VERBRUGGEN ALFONS (BE)
BORMANS GUY (BE)
VERBRUGGEN ALFONS (BE)
International Classes:
A61K51/04; C07C311/37; C07F1/08; C07F5/00; C07F13/00
Domestic Patent References:
| WO2003089013A1 | 2003-10-30 |
Other References:
HUSIC H DAVID ET AL: "Identification of intracellular carbonic anhydrase in Chlamydomonas reinhardtii with a carbonic anhydrase-directed photoaffinity label", PLANT PHYSIOLOGY (ROCKVILLE), vol. 105, no. 1, 1994, pages 133 - 139, XP002579112, ISSN: 0032-0889
SCOZZAFAVA A ET AL: "Carbonic anhydrase inhibitors and activators and their use in therapy", EXPERT OPINION ON THERAPEUTIC PATENTS 200612 GB LNKD- DOI:10.1517/13543776.16.12.1627, vol. 16, no. 12, December 2006 (2006-12-01), pages 1627 - 1664, XP002579113, ISSN: 1354-3776
ZHANG J Y ET AL: "Pharmacokinetics and metabolism of a COX-2 inhibitor, valdecoxib, in mice", DRUG METABOLISM AND DISPOSITION, WILLIAMS AND WILKINS, BALTIMORE, MD, US LNKD- DOI:10.1124/DMD.31.4.491, vol. 31, no. 4, 1 April 2003 (2003-04-01), pages 491 - 501, XP002311622, ISSN: 0090-9556
SCOZZAFAVA A ET AL: "Carbonic anhydrase inhibitors and activators and their use in therapy", EXPERT OPINION ON THERAPEUTIC PATENTS 200612 GB LNKD- DOI:10.1517/13543776.16.12.1627, vol. 16, no. 12, December 2006 (2006-12-01), pages 1627 - 1664, XP002579113, ISSN: 1354-3776
ZHANG J Y ET AL: "Pharmacokinetics and metabolism of a COX-2 inhibitor, valdecoxib, in mice", DRUG METABOLISM AND DISPOSITION, WILLIAMS AND WILKINS, BALTIMORE, MD, US LNKD- DOI:10.1124/DMD.31.4.491, vol. 31, no. 4, 1 April 2003 (2003-04-01), pages 491 - 501, XP002311622, ISSN: 0090-9556
Attorney, Agent or Firm:
Katholieke Universiteit Leuven (Minderbroedersstraat 8A - bus 5105, leuven, BE)
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