Title:
BLOOD PURIFIER
Document Type and Number:
WIPO Patent Application WO/2020/203923
Kind Code:
A1
Abstract:
Provided is a blood purifier that comprises a porous molded body; that exhibits an excellent blood compatibility wherein platelet adherence is inhibited and exhibits a good cytokine adsorption capacity and a low pressure loss before and after blood treatment; and that can be safely used. Disclosed is a blood purifier that comprises a main vessel and a porous molded body housed in the main vessel. The porous molded body contains a hydrophobic polymer and a hydrophilic polymer. The amount of low-melting-point water per 1 g of dry weight of the porous molded body is 0.12 g to 2.00 g. The contact change ratio for the porous molded body is 0% to 0.2%. The ratio L/D is 1.00 to 2.30 where, for the region taken up by the porous molded body in the main vessel, L is the length in the flow direction and D is the circle-equivalent diameter of the cross section in the direction perpendicular to the flow direction. The circle-equivalent diameter D is calculated based on formula (A):
D = 2√(V/L/3.14) (A).
In formula (A), V is the apparent volume of the region taken up by the porous molded body in the main vessel. In addition, when an aqueous polyvinylpyrrolidone solution with a viscosity adjusted to 3.75 mPa·s to 3.85 mPa·s is flowed through the blood purifier at a flow-through rate of 400 mL/minute, the pressure loss of the blood purifier before blood treatment is less than 13 kPa and the pressure loss of the blood purifier after blood treatment is less than 13 kPa.
Inventors:
OISHI TERUHIKO (JP)
TOKIMIZU YUSUKE (JP)
MATSUYAMA KEITARO (JP)
MORITA NAOKI (JP)
TOKIMIZU YUSUKE (JP)
MATSUYAMA KEITARO (JP)
MORITA NAOKI (JP)
Application Number:
PCT/JP2020/014376
Publication Date:
October 08, 2020
Filing Date:
March 27, 2020
Export Citation:
Assignee:
ASAHI KASEI MEDICAL CO LTD (JP)
International Classes:
B01J20/06; A61M1/02; A61M1/36; B01J20/08; B01J20/10; B01J20/28; B01J20/30
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Other References:
TANAKA, MASARU ET AL.: "Thermal characterization of novel polymers for biomedical applications", NETSU SOKUTEI, vol. 39, no. 4, 2012, pages 151 - 157
SHINGO KOBAYASHI: "B2) Precise synthesis technology of novel medical intermediate water-containing polymers", NEW TECHNICAL BRIEFING, 22 January 2015 (2015-01-22), JP, pages 1 - 17, XP009529818
NAKAOKA, RYUSUKE: "Biological safety assessment required for approval examination of medical device and its international standardization status", SYMPOSIUM 2016 OF THE JAPANESE SOCIETY FOR BIOMATERIALS; NOVEMBER 21-22, 2016, 21 November 2016 (2016-11-21), JP, pages 1 - 21, XP009529819
SHIGEAKI MORITAMASARU TANAKAYUKIHIRO OZAKI: "Time-Resolved In Situ ATR-IR Observations of the Process of Sorption of Water into a Poly(2-methoxyethyl acrylate) Film", LANGMUIR, vol. 23, no. 7, 3 March 2007 (2007-03-03), pages 3750 - 3761
T. TSURUTAJ. BIOMATER. ET AL.: "The roles of water molecules in the interfaces between biological systems and polymers", SCI. POLVM. ED., vol. 21, 2010, pages 1827 - 1920
See also references of EP 3950117A4
SHINGO KOBAYASHI: "B2) Precise synthesis technology of novel medical intermediate water-containing polymers", NEW TECHNICAL BRIEFING, 22 January 2015 (2015-01-22), JP, pages 1 - 17, XP009529818
NAKAOKA, RYUSUKE: "Biological safety assessment required for approval examination of medical device and its international standardization status", SYMPOSIUM 2016 OF THE JAPANESE SOCIETY FOR BIOMATERIALS; NOVEMBER 21-22, 2016, 21 November 2016 (2016-11-21), JP, pages 1 - 21, XP009529819
SHIGEAKI MORITAMASARU TANAKAYUKIHIRO OZAKI: "Time-Resolved In Situ ATR-IR Observations of the Process of Sorption of Water into a Poly(2-methoxyethyl acrylate) Film", LANGMUIR, vol. 23, no. 7, 3 March 2007 (2007-03-03), pages 3750 - 3761
T. TSURUTAJ. BIOMATER. ET AL.: "The roles of water molecules in the interfaces between biological systems and polymers", SCI. POLVM. ED., vol. 21, 2010, pages 1827 - 1920
See also references of EP 3950117A4
Attorney, Agent or Firm:
AOKI, Atsushi et al. (JP)
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