Title:
BLOOD SUBSTITUTES
Document Type and Number:
WIPO Patent Application WO2005041898
Kind Code:
A3
Abstract:
The functional characteristics of heme proteins can be modified to produce hemoglobins that can be used as blood substitutes in different therapeutic applications. Stable polymers of tetrameric hemoglobin, and of myoglobin molecules, are provided for use in the blood substitutes.
Inventors:
FRONTICELLI CLARA (US)
BRINIGAR WILLIAM S (US)
BRINIGAR WILLIAM S (US)
Application Number:
PCT/US2004/036544
Publication Date:
September 01, 2005
Filing Date:
November 01, 2004
Export Citation:
Assignee:
UNIV TEMPLE (US)
JOHNS OPKINS UNIVERSITY LTD (US)
FRONTICELLI CLARA (US)
BRINIGAR WILLIAM S (US)
JOHNS OPKINS UNIVERSITY LTD (US)
FRONTICELLI CLARA (US)
BRINIGAR WILLIAM S (US)
International Classes:
A61K35/14; A61K38/42; C07K14/805; A61K38/00; A61K; (IPC1-7): A61K35/14
Foreign References:
| US5888766A | 1999-03-30 | |||
| US5028588A | 1991-07-02 |
Other References:
KROLL J. ET AL: "Chemical reactions of Benzyl Isothiocyanate with Myoglobin.", J. SCI. FOOD AGRIC., vol. 72, 1996, pages 376 - 384, XP008048241
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