Title:
BLUE-COLORED GOLD NANOPARTICLES FOR IMMUNOLOGICAL MEASUREMENT, PROCESS FOR PRODUCTION OF SAME, AND MEASUREMENT METHOD USING SAME
Document Type and Number:
WIPO Patent Application WO/2012/060456
Kind Code:
A1
Abstract:
A nuclei formation step of reacting an organic buffering agent having a piperazine ring with a solution of a first gold salt to form nuclear gold nanoparticles and a growth step of growing the nuclear gold nanoparticles by simultaneously adding a solution of a second gold salt and an organic acid having reducing properties to the solution of the nuclear gold nanoparticles to cause the reaction of these components are carried out. Thus, it becomes possible to readily produce gold nanoparticles which can be dispersed into a colloid solution having a blue color as determined by visual examination and each of which comprises an organic buffering agent having a piperazine ring, gold and an organic acid having reducing properties. The gold nanoparticles thus produced can be used as labeling particles for use in immunological measurement methods.
Inventors:
KATO YUYA
ITO DAISUKE
KITANI YOSHIKO
ITO DAISUKE
KITANI YOSHIKO
Application Number:
PCT/JP2011/075519
Publication Date:
May 10, 2012
Filing Date:
November 04, 2011
Export Citation:
Assignee:
TANAKA PRECIOUS METAL IND (JP)
KATO YUYA
ITO DAISUKE
KITANI YOSHIKO
KATO YUYA
ITO DAISUKE
KITANI YOSHIKO
International Classes:
B22F1/00; B22F9/24; G01N33/543
Foreign References:
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Other References:
CHEM. MATER., vol. 19, 2007, pages 2823 - 2830
LANGMUIR, vol. 21, 2005, pages 2012 - 2016
J. PHYS. CHEM. B, vol. 110, 2006, pages 19291 - 19294
NANO LETT., vol. 6, 2006, pages 683 - 688
KOHLER; MILSTEIN, NATURE, vol. 256, 1975, pages 495 - 497
See also references of EP 2636469A4
LANGMUIR, vol. 21, 2005, pages 2012 - 2016
J. PHYS. CHEM. B, vol. 110, 2006, pages 19291 - 19294
NANO LETT., vol. 6, 2006, pages 683 - 688
KOHLER; MILSTEIN, NATURE, vol. 256, 1975, pages 495 - 497
See also references of EP 2636469A4
Attorney, Agent or Firm:
OGURI Shohei et al. (JP)
Shohei Oguri (JP)
Shohei Oguri (JP)
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Claims: