Title:
BONE MARROW CELL DIFFERENTIATION
Document Type and Number:
WIPO Patent Application WO2004035761
Kind Code:
A3
Abstract:
Bone marrow cells are induced to differentiate into pancreatic hormone-producing cells in vitro and to repopulate a pancreas in vivo. These insulin-producing cells can be used to regenerate a damaged pancreas and reverse hyperglycemia in mammals.
Inventors:
PETERSEN BRYON E
OH SEH-HOON
OH SEH-HOON
Application Number:
PCT/US2003/033165
Publication Date:
November 25, 2004
Filing Date:
October 17, 2003
Export Citation:
Assignee:
UNIV FLORIDA (US)
International Classes:
C12N5/071; (IPC1-7): C12N5/06; C12N5/08
Domestic Patent References:
| WO1999050048A1 | 1999-10-07 |
Foreign References:
| US6458589B1 | 2002-10-01 |
Other References:
RICORDI C. ET AL: "Indefinite survival of rat islet allografts following infusion of donor bone marrow without cytoablation", CELL TRANSPLANTATION, vol. 5, no. 1, 1996, pages 53 - 55, XP002981873
YANG ET AL: "In vitro transdifferentiation of adult hepatic stem cells into pancreatic endocrine cells", BLOOD, vol. 98, no. 11, November 2001 (2001-11-01), pages 548A, XP009013671
YANG ET AL: "In vitro transdifferentiation of adult hepatic stem cells into pancreatic endocrine hormone producing cells", PNAS, vol. 99, no. 12, June 2002 (2002-06-01), pages 8078 - 8083, XP002961837
PETERSEN ET AL: "Bone marrow as a potential source of hepatic oval cells", SCIENCE, vol. 284, May 1999 (1999-05-01), pages 1168 - 1170, XP002936518
See also references of EP 1551958A4
YANG ET AL: "In vitro transdifferentiation of adult hepatic stem cells into pancreatic endocrine cells", BLOOD, vol. 98, no. 11, November 2001 (2001-11-01), pages 548A, XP009013671
YANG ET AL: "In vitro transdifferentiation of adult hepatic stem cells into pancreatic endocrine hormone producing cells", PNAS, vol. 99, no. 12, June 2002 (2002-06-01), pages 8078 - 8083, XP002961837
PETERSEN ET AL: "Bone marrow as a potential source of hepatic oval cells", SCIENCE, vol. 284, May 1999 (1999-05-01), pages 1168 - 1170, XP002936518
See also references of EP 1551958A4
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