Title:
BONE METABOLIC CELL MODULATOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/027132
Kind Code:
A1
Abstract:
The present invention provides: a bone metabolic cell modulator including at least one polypeptide selected from the group consisting of Chromosome 4 Open Reading Frame 48 (C4orf48), C4orf48 variants having at least one among the ability to inhibit bone resorption by osteoclasts and the ability to promote osteogenesis by osteoblasts, and C4orf48 derivatives having at least one among the ability to inhibit bone resorption by osteoclasts and the ability to promote osteogenesis by osteoblasts, or a nucleic acid encoding the polypeptide; and a pharmaceutical composition for treating or preventing a disease or condition, such as osteoporosis, through which an increase in bone is anticipated.
Inventors:
TERUKAWA ALAA (JP)
MATSUMAE GEN (JP)
EBATA TAKU (JP)
SHIMIZU TOMOHIRO (JP)
TAKAHASHI DAISUKE (JP)
KADOYA KEN (JP)
IWASAKI NORIMASA (JP)
MATSUMAE GEN (JP)
EBATA TAKU (JP)
SHIMIZU TOMOHIRO (JP)
TAKAHASHI DAISUKE (JP)
KADOYA KEN (JP)
IWASAKI NORIMASA (JP)
Application Number:
PCT/JP2022/031961
Publication Date:
March 02, 2023
Filing Date:
August 24, 2022
Export Citation:
Assignee:
UNIV HOKKAIDO NAT UNIV CORP (JP)
International Classes:
A61K38/16; A61K38/10; A61P1/02; A61P19/02; A61P19/08; A61P19/10; A61P29/00; A61P35/04; A61P43/00
Domestic Patent References:
| WO2020032076A1 | 2020-02-13 |
Other References:
SABINE ENDELE; CLAUDIA NELKENBRECHER; ANNEGRET BöRDLEIN; STEFANIE SCHLICKUM; ANDREAS WINTERPACHT: "C4ORF48, a gene from the Wolf-Hirschhorn syndrome critical region, encodes a putative neuropeptide and is expressed during neocortex and cerebellar development", NEUROGENETICS ;, SPRINGER, BERLIN, DE, vol. 12, no. 2, 2 February 2011 (2011-02-02), Berlin, DE , pages 155 - 163, XP019901947, ISSN: 1364-6753, DOI: 10.1007/s10048-011-0275-8
GUAN ENCUI, TIAN FENG, LIU ZHAOXIA: "A novel risk score model for stomach adenocarcinoma based on the expression levels of 10 genes", ONCOLOGY LETTERS, SPANDIDOS PUBLICATIONS, GR, GR , XP093038701, ISSN: 1792-1074, DOI: 10.3892/ol.2019.11190
GUAN ENCUI, TIAN FENG, LIU ZHAOXIA: "A novel risk score model for stomach adenocarcinoma based on the expression levels of 10 genes", ONCOLOGY LETTERS, SPANDIDOS PUBLICATIONS, GR, GR , XP093038701, ISSN: 1792-1074, DOI: 10.3892/ol.2019.11190
Attorney, Agent or Firm:
IP-ASSIST PATENT OFFICE (JP)
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