Title:
BONE MORPHOGENETIC COMPOUND AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2014/148718
Kind Code:
A1
Abstract:
The present invention provides a spirostenol derivative, a composition for inducing a bone formation and/or promoting an osteoblast differentiation which includes the spirostenol derivative as an active ingredient, a biomaterial for inducing osteogenic differentiation which includes the composition, a pharmaceutical composition for treating and/or preventing bone metabolism diseases, and an engineered food composition and/or health functional food which are/is for improving the function of osteoblasts. The derivative of the present invention is virtually non-cytotoxic, induces the formation of osteoblasts without causing a decrease in the activity against UV or the like, can be administered in vivo, and forms a complex with a substance having a bone conduction performance and thus is expected to be capable of being applied to medical devices and the like.
Inventors:
LEE DONG HEE (KR)
JUNG HA NA (KR)
YU JI WON (KR)
PARK WON CHOUL (KR)
JUNG HA NA (KR)
YU JI WON (KR)
PARK WON CHOUL (KR)
Application Number:
PCT/KR2013/009835
Publication Date:
September 25, 2014
Filing Date:
November 01, 2013
Export Citation:
Assignee:
CELLINBIO CO LTD (KR)
International Classes:
C07J9/00; A61K31/575; A61P19/00; C07H15/24
Domestic Patent References:
| WO2003086411A1 | 2003-10-23 |
Foreign References:
| US20040147495A1 | 2004-07-29 | |||
| KR20110122576A | 2011-11-10 | |||
| KR19990077143A | 1999-10-25 | |||
| KR20050061271A | 2005-06-22 | |||
| KR20050071889A | 2005-07-08 | |||
| EP0066458A1 | 1982-12-08 | |||
| JPS6393718A | 1988-04-25 |
Other References:
ALCANTARA, E. H. ET AL.: "Diosgenin stimulates osteogenic activity by increasing bone matrix proteins synthesis and bone-specific transcription factor Runx2 in osteoblastic MC 3T3-E1 cells.", J. NUTR. BIOCHEM., vol. 22, no. 11, 2 February 2011 (2011-02-02), pages 1055 - 1063
HIRANO, A. ET AL.: "Arginine-Assisted Solubilization System for Drug Substances: Solubility Experiment and Simulation.", J. PHYS. CHEM. B, vol. 114, no. 42, 6 October 2010 (2010-10-06), pages 13455 - 13462
HIRANO, A. ET AL.: "Arginine-Assisted Solubilization System for Drug Substances: Solubility Experiment and Simulation.", J. PHYS. CHEM. B, vol. 114, no. 42, 6 October 2010 (2010-10-06), pages 13455 - 13462
Attorney, Agent or Firm:
NEIT INTERNATIONAL PATENT AND LAW FIRM (KR)
특허법인네이트 (KR)
특허법인네이트 (KR)
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