Title:
BONE REPAIR MATERIAL AND PRODUCTION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2014/027612
Kind Code:
A1
Abstract:
[Problem] To provide a highly safe bone repair material that gradually releases bone-forming ions and that exhibits excellent apatite-forming ability and storability. [Solution] The production method of the present invention is characterized by comprising: a step in which a substrate comprising titanium or a titanium alloy is immersed in an alkaline first aqueous solution that contains cations of sodium ions and/or potassium ions and that does not contain calcium ions or bone-forming ions; a step in which the substrate is immersed in a second solution that contains calcium ions and at least one kind of bone-forming ions selected from among strontium ions, magnesium ions, zinc ions, lithium ions, and gallium ions; a step in which the substrate is heated in a dry atmosphere; and a step in which the substrate is immersed in a third aqueous solution containing at least one of water, an acidic aqueous solution, and/or an aqueous solution containing bone-forming ions.
Inventors:
KOKUBO TADASHI (JP)
MATSUSHITA TOMIHARU (JP)
NATH SHEKHAR (JP)
YAMAGUCHI SEIJI (JP)
MATSUSHITA TOMIHARU (JP)
NATH SHEKHAR (JP)
YAMAGUCHI SEIJI (JP)
Application Number:
PCT/JP2013/071596
Publication Date:
February 20, 2014
Filing Date:
August 09, 2013
Export Citation:
Assignee:
UNIV CHUBU EDUCATIONAL FOUNDATION (JP)
International Classes:
A61L27/00
Domestic Patent References:
| WO2009147819A1 | 2009-12-10 | |||
| WO1995013100A1 | 1995-05-18 |
Foreign References:
| JP2011032223A | 2011-02-17 | |||
| JP2010533012A | 2010-10-21 | |||
| JP2006075500A | 2006-03-23 | |||
| JP2010533011A | 2010-10-21 | |||
| JP2002102330A | 2002-04-09 | |||
| JP2000093498A | 2000-04-04 |
Other References:
SEIJI YAMAGUCHI ET AL.: "23. Shudai 3 Kokyodo Teidansei Seitai Kassei Titanium-kei Zairyo no Chosei", DAI 30 KAI ANNUAL MEETING OF THE RESEARCH SOCIETY FOR ORTHOPAEDIC BIOMATERIALS PROGRAM - SHOROKUSHU, 30 November 2010 (2010-11-30), pages 44
SEIJI YAMAGUCHI ET AL.: "Symposium 1 Kanren 01 Strontium Ion o Joho suru Seitai Kassei Titanium Kinzoku", DAI 32 KAI ANNUAL MEETING OF THE RESEARCH SOCIETY FOR ORTHOPAEDIC BIOMATERIALS PROGRAM - SHOROKUSHU, 17 December 2012 (2012-12-17), pages 19
SEIJI YAMAGUCHI ET AL.: "Symposium 1 Kanren 01 Strontium Ion o Joho suru Seitai Kassei Titanium Kinzoku", DAI 32 KAI ANNUAL MEETING OF THE RESEARCH SOCIETY FOR ORTHOPAEDIC BIOMATERIALS PROGRAM - SHOROKUSHU, 17 December 2012 (2012-12-17), pages 19
Attorney, Agent or Firm:
YANO, MASAYUKI (JP)
Masayuki Yano (JP)
Masayuki Yano (JP)
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